Results 61 to 70 of about 21,606,107 (313)
SARS-CoV-2 induces “cytokine storm” hyperinflammatory responses in RA patients through pyroptosis
Frontiers in Immunology, 2022 BackgroundThe coronavirus disease (COVID-19) is a pandemic disease that threatens worldwide public health, and rheumatoid arthritis (RA) is the most common autoimmune disease.
Qingcong Zheng +7 more
doaj +1 more source
Caspase-1 activates gasdermin A in non-mammals
eLife, 2023 Gasdermins oligomerize to form pores in the cell membrane, causing regulated lytic cell death called pyroptosis. Mammals encode five gasdermins that can trigger pyroptosis: GSDMA, B, C, D, and E. Caspase and granzyme proteases cleave the linker regions of and activate GSDMB, C, D, and E, but no endogenous activation pathways are yet known for GSDMA ...
Stephen Bela Kovacs +5 more
openaire +4 more sources
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Adipose tissue IL‐18 production is independent of caspase‐1 and caspase‐11
Immunity, Inflammation and DiseaseBackground Inflammation in adipose tissue, resulting from imbalanced caloric intake and energy expenditure, contributes to the metabolic dysregulation observed in obesity.
Luis Román‐Domínguez +4 more
doaj +1 more source
Caspase-9 swings both ways in the apoptosome
Molecular & Cellular Oncology, 2017 For nearly 2 decades, investigators have debated whether cysteinyl-aspartate-specific protease 9 (caspase-9) is activated within the apoptotic protease-activating factor 1 (Apaf-1) apoptosome through proximity-induced homodimerization or through ...
Chu-Chiao Wu, Shawn B. Bratton
doaj +1 more source
Targeting Pyroptotic Cell Death Pathways in Retinal Disease
Frontiers in Medicine, 2022 Pyroptosis is a gasdermin-mediated, pro-inflammatory form of cell death distinct from apoptosis. In recent years, increasing attention has shifted toward pyroptosis as more studies demonstrate its involvement in diverse inflammatory disease states ...
Mary Zhao, Siqi Li, Joanne A. Matsubara
doaj +1 more source
THE ROLE OF INFLAMMASOME AND CASPASE-1 IN REGULATING ADAPTIVE RESPONSE TO OXIDATIVE STRESS IN MOUSE HEPATOCYTES [PDF]
, 2013 In myeloid cells, oxidative stress can induce the activation of caspase-1 through canonical inflammasome signaling, which leads to the release of proinflammatory cytokines IL-1β/IL-18 and a potentially damaging inflammatory response.
Sun, Qian
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
PLoS Pathogens, 2020 We investigated the role of the inflammasome effector caspases-1 and -11 during Salmonella enterica serovar Typhimurium infection of murine intestinal epithelial cells (IECs).
Shauna M Crowley +6 more
doaj +1 more source
Cleavage of pro-caspase-1 into caspase-1 by HMPV.
, 2019 THP-1 cells were differenciated into macrophages using PMA (100 ng/ml) before treatment with 10 μM of MCC950 or DMSO (control) and then infected or not with HMPV or HMPV ΔSH at a MOI of 0.001.
Vuong B. Lê (393003) +8 more
core +1 more source