Results 61 to 70 of about 360,151 (357)
Nlrp6 promotes recovery after peripheral nerve injury independently of inflammasomes [PDF]
, 2015 Background: NOD-like receptors (Nlrs) are key regulators of immune responses during infection and autoimmunity. A subset of Nlrs assembles inflammasomes, molecular platforms that are activated in response to endogenous danger and microbial ligands and ...
De Winter, Vicky +6 more
core +2 more sources
A Role for Caspase-1 in Heart Failure [PDF]
Circulation Research, 2007 Apoptosis of cardiomyocytes is increased in heart failure and has been implicated in disease progression. The activation of “proapoptotic” caspases represents a key step in cardiomyocyte apoptosis. In contrast, the role of “proinflammatory” caspases (caspases 1, 4, 5, 11, 12) is unclear. Here, we study the cardiac function of caspase-1.
Sabine, Merkle +8 more
openaire +2 more sources
Characterizing caspase-1 involvement during esophageal disease progression [PDF]
Cancer Immunology, Immunotherapy, 2020 Barrett's esophagus (BE) is an inflammatory condition and a neoplastic precursor to esophageal adenocarcinoma (EAC). Inflammasome signaling, which contributes to acute and chronic inflammation, results in caspase-1 activation leading to the secretion of IL-1β and IL-18, and inflammatory cell death (pyroptosis).
Gillian Barber +18 more
openaire +4 more sources
Spotlight on pyroptosis: role in pathogenesis and therapeutic potential of ocular diseases
Journal of Neuroinflammation, 2022 Pyroptosis is a programmed cell death characterized by swift plasma membrane disruption and subsequent release of cellular contents and pro-inflammatory mediators (cytokines), including IL‐1β and IL‐18.
Meini Chen, Rong Rong, Xiaobo Xia
doaj +1 more source
Caspase-1 clipping causes complications for α-synuclein [PDF]
Proceedings of the National Academy of Sciences, 2016 The study of human neurodegeneration has increasingly focused on a clinically diverse group of diseases that share the common pathologic feature of insoluble aggregates of α-synuclein (αSyn) in various populations of neurons and glia. Scientists have begun identifying factors that may initiate or accelerate αSyn aggregation and how this process relates
Silke, Nuber, Dennis J, Selkoe
openaire +2 more sources
Cell & Bioscience, 2019 Pyroptosis, a type of programmed cell death that along with inflammation, is mainly regulated by two main pathways, cysteinyl aspartate specific proteinase (caspase)-1-induced canonical inflammatory pathway and caspase-11-induced non-canonical ...
Xiaoli Huang +10 more
doaj +1 more source
Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids. [PDF]
, 2016 The beta amyloid (Aβ) and other aggregating proteins in the brain increase with age and are frequently found within neurons. The mechanistic relationship between intracellular amyloid, aging and neurodegeneration is not, however, well understood.
Currais, Antonio +5 more
core +2 more sources
Role of Caspase 1 in Neurologic Disease [PDF]
Archives of Neurology, 2000 In recent years substantial advances have taken place in understanding the mechanistic pathways mediating neuronal cell death in a variety of neurologic diseases. Since the central nervous system (CNS) has little, if any, power of functional neuronal regeneration, prevention of neuronal cell death is an important target of modern neurotherapeutics.
openaire +2 more sources
The Role of Non-canonical and Canonical Inflammasomes in Inflammaging
Frontiers in Molecular Neuroscience, 2022 Neurodegenerative diseases currently affect millions of people worldwide and continues to increase in the expanding elderly population. Neurodegenerative diseases usually involve cognitive decline and are among the top causes of death.
Brianna Cyr +5 more
doaj +1 more source
SalmonellaPromotes ASC Oligomerization-dependent Caspase-1 Activation [PDF]
Immune Network, 2012 Innate immune cells sense and respond to the cytoplasmic infection of bacterial pathogens through NLRP3, NLRC4 or AIM2 inflammasome depending on the unique molecular pattern of invading pathogens. The infection of flagellin- or type III secretion system (T3SS)-containing Gram-negative bacteria such as Salmonella enterica serovar Typhimurium (S ...
Inhwa Hwang +4 more
openaire +2 more sources