Results 71 to 80 of about 30,081,745 (303)

Role of caspase-1 in regulation of triglyceride metabolism [PDF]

Proceedings of the National Academy of Sciences, 2013
Caspase-1 is a cysteine protease that can be activated by both endogenous and exogenous inflammatory stimuli and has been shown to have important functions in processes as diverse as proteolytic activation of cytokines, cell death, and membrane repair. Caspase-1–dependent production of the inflammatory cytokines IL-1 and IL-18 has also been implicated ...
Maya E, Kotas, Michael J, Jurczak, Charles, Annicelli, Matthew P, Gillum, Gary W, Cline, Gerald I, Shulman, Ruslan, Medzhitov   +6 more
openaire   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Caspase-9 swings both ways in the apoptosome

Molecular & Cellular Oncology, 2017
For nearly 2 decades, investigators have debated whether cysteinyl-aspartate-specific protease 9 (caspase-9) is activated within the apoptotic protease-activating factor 1 (Apaf-1) apoptosome through proximity-induced homodimerization or through ...
Chu-Chiao Wu, Shawn B. Bratton
doaj   +1 more source

Caspase-1 Mediates Resistance in Murine Melioidosis [PDF]

Infection and Immunity, 2009
ABSTRACT The gram-negative rod Burkholderia pseudomallei is the causative agent of melioidosis, a potentially fatal disease which is endemic in tropical and subtropical areas. The bacterium multiplies intracellularly within the cytosol, induces the formation of actin tails, and can spread directly from ...
Breitbach, K., Kohler, J., Eske, K., Wongprompitak, P., Steinmetz, I., Sun, G.W., Liu, Y., Gan, Y.-H., Tan, G.   +8 more
openaire   +2 more sources

Caspase-1 inhibition by YVAD generates tregs pivoting IL-17 to IL-22 response in β-glucan induced airway inflammation

, 2022
During Aspergillus fumigatus mediated lung inflammation, NLRP3 inflammasome is rapidly activated that aggravates IL-1β production contributing to lung inflammation.
Parameswar Dalai (12159242), Divyesh Patel (5476793), Shivani Yadav (12159236), Dipeeka Mandaliya (12159233), Hima Vora (12159245), Omkar Naik (12159239), Dhruvi Shah (4951405), Naveen Challagundla (12159230), Reena Agrawal-Rajput (4951399)   +8 more
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Abnormal expression of miR-3653-3p, caspase 1, IL-1β in peripheral blood of schizophrenia

BMC Psychiatry, 2023
Schizophrenia (SCZ) is a chronic, highly relapsing, severe mental disorder with an unclear etiology. Cytokine-mediated neuroimmune abnormalities have been repeatedly revealed. IL-1β was reported to play a vital role in expanding the inflammatory response.
Xin-ling Zhao, Yi-lin Liu, Qing Long, Yun-qiao Zhang, Xu You, Ze-yi Guo, Xiang Cao, Lei Yu, Fu-yi Qin, Zhao-wei Teng, Yong Zeng   +10 more
doaj   +1 more source

SARS-CoV-2 induces “cytokine storm” hyperinflammatory responses in RA patients through pyroptosis

Frontiers in Immunology, 2022
BackgroundThe coronavirus disease (COVID-19) is a pandemic disease that threatens worldwide public health, and rheumatoid arthritis (RA) is the most common autoimmune disease.
Qingcong Zheng, Rongjie Lin, Yuchao Chen, Qi Lv, Jin Zhang, Jingbo Zhai, Weihong Xu, Wanming Wang   +7 more
doaj   +1 more source

Caspase-1 activates gasdermin A in non-mammals

eLife, 2023
Gasdermins oligomerize to form pores in the cell membrane, causing regulated lytic cell death called pyroptosis. Mammals encode five gasdermins that can trigger pyroptosis: GSDMA, B, C, D, and E. Caspase and granzyme proteases cleave the linker regions of and activate GSDMB, C, D, and E, but no endogenous activation pathways are yet known for GSDMA ...
Stephen Bela Kovacs, Zachary Paul Billman, Bo Wei, Kidong Kang, Ousmane H Cissé, Edward A Miao   +5 more
openaire   +4 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source