Results 81 to 90 of about 30,081,745 (303)
Targeting Pyroptotic Cell Death Pathways in Retinal Disease
Frontiers in Medicine, 2022 Pyroptosis is a gasdermin-mediated, pro-inflammatory form of cell death distinct from apoptosis. In recent years, increasing attention has shifted toward pyroptosis as more studies demonstrate its involvement in diverse inflammatory disease states ...
Mary Zhao, Siqi Li, Joanne A. Matsubara
doaj +1 more source
Compartmentalized megakaryocyte death generates functional platelets committed to caspase-independent death [PDF]
, 2003 Caspase-directed apoptosis usually fragments cells, releasing nonfunctional, prothrombogenic, membrane-bound apoptotic bodies marked for rapid engulfment by macrophages.
Jones, David B. +9 more
core +1 more source
, 2022 Western blot of pro- and cleaved caspase-3 [ratio to ß-actin]. Shown are representative blots separated by location of lung tissue sampling (contusion site, ipsilateral control, and contralateral control). Lung tissue samples were homogenized, separated,
Martin Sassen (14232410) +7 more
core +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Downregulation of RCN1 promotes pyroptosis in acute myeloid leukemia cells
Molecular Oncology, 2023 Reticulocalbin‐1 (RCN1) is expressed aberrantly and at a high level in various tumors, including acute myeloid leukemia (AML), yet its impact on AML remains unclear. In this study, we demonstrate that RCN1 knockdown significantly suppresses the viability
Sisi Deng +11 more
doaj +1 more source
NALP3: a key player in caspase-1 activation [PDF]
Journal of Endotoxin Research, 2006 The NLR (NACHT-LRR) family of proteins have been implicated in the regulation of immune responses and cell death pathways. Some NLR family members can form multiprotein complexes, called inflammasomes, involved in the activation of pro-inflammatory caspases.
Fayyaz S, Sutterwala +4 more
openaire +2 more sources
Caspase-8 content in SNU-1 cells.
, 2021 Increases in intracellular Caspase-8 compared to blank (untreated) SNU-1 cells upon treatment with 50–5000 nm sized aminated, carboxylated and NF particles for 4 h. Data compared with respect to surface functionalization (A) or particle size (B).
Amrita Banerjee (382658) +2 more
core +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Pathogens, 2020 Ischemia reperfusion injury (IRI) during liver transplantation increases morbidity and contributes to allograft dysfunction. There are no therapeutic strategies to mitigate IRI.
Alexander M. Fagenson +13 more
doaj +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source