Results 51 to 60 of about 329,630 (269)

Abnormal expression of miR-3653-3p, caspase 1, IL-1β in peripheral blood of schizophrenia

BMC Psychiatry, 2023
Schizophrenia (SCZ) is a chronic, highly relapsing, severe mental disorder with an unclear etiology. Cytokine-mediated neuroimmune abnormalities have been repeatedly revealed. IL-1β was reported to play a vital role in expanding the inflammatory response.
Xin-ling Zhao, Yi-lin Liu, Qing Long, Yun-qiao Zhang, Xu You, Ze-yi Guo, Xiang Cao, Lei Yu, Fu-yi Qin, Zhao-wei Teng, Yong Zeng   +10 more
doaj   +1 more source

Caspase-1 Mediates Resistance in Murine Melioidosis [PDF]

Infection and Immunity, 2009
ABSTRACT The gram-negative rod Burkholderia pseudomallei is the causative agent of melioidosis, a potentially fatal disease which is endemic in tropical and subtropical areas. The bacterium multiplies intracellularly within the cytosol, induces the formation of actin tails, and can spread directly from ...
Breitbach, K., Kohler, J., Eske, K., Wongprompitak, P., Steinmetz, I., Sun, G.W., Liu, Y., Gan, Y.-H., Tan, G.   +8 more
openaire   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Caspase-1 activates gasdermin A in non-mammals

eLife, 2023
Gasdermins oligomerize to form pores in the cell membrane, causing regulated lytic cell death called pyroptosis. Mammals encode five gasdermins that can trigger pyroptosis: GSDMA, B, C, D, and E. Caspase and granzyme proteases cleave the linker regions of and activate GSDMB, C, D, and E, but no endogenous activation pathways are yet known for GSDMA ...
Stephen Bela Kovacs, Zachary Paul Billman, Bo Wei, Kidong Kang, Ousmane H Cissé, Edward A Miao   +5 more
openaire   +4 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The ASC Speck and NLRP3 Inflammasome Function Are Spatially and Temporally Distinct

Frontiers in Immunology, 2021
Although considered the ternary inflammasome structure, whether the singular, perinuclear NLRP3:ASC speck is synonymous with the NLRP3 inflammasome is unclear.
Abhinit Nagar, Tabassum Rahman, Jonathan A. Harton   +2 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Liver Ischemia Reperfusion Injury, Enhanced by Trained Immunity, Is Attenuated in Caspase 1/Caspase 11 Double Gene Knockout Mice

Pathogens, 2020
Ischemia reperfusion injury (IRI) during liver transplantation increases morbidity and contributes to allograft dysfunction. There are no therapeutic strategies to mitigate IRI.
Alexander M. Fagenson, Keman Xu, Fatma Saaoud, Gayani Nanayakkara, Nirag C. Jhala, Lu Liu, Charles Drummer, Yu Sun, Kwan N. Lau, Antonio Di Carlo, Xiaohua Jiang, Hong Wang, Sunil S. Karhadkar, Xiaofeng Yang   +13 more
doaj   +1 more source

NLRP3 Inflammasome Involved with Viral Replication in Cytopathic NADL BVDV Infection and IFI16 Inflammasome Connected with IL-1β Release in Non-Cytopathic NY-1 BVDV Infection in Bovine Macrophages

Viruses, 2023
Inflammasomes are multiprotein complexes that play a role in the processing of proinflammatory cytokines such as interleukin 1 beta (IL-1β). The secretion of IL-1β in bovine macrophages infected with the bovine viral diarrhea virus (BVDV) cytopathic ...
Claudia Gallegos-Rodarte, Omar Escobar-Chavarría, Meztli Miroslava Cantera-Bravo, Rosa Elena Sarmiento-Silva, Alejandro Benitez-Guzman   +4 more
doaj   +1 more source

NALP3: a key player in caspase-1 activation [PDF]

Journal of Endotoxin Research, 2006
The NLR (NACHT-LRR) family of proteins have been implicated in the regulation of immune responses and cell death pathways. Some NLR family members can form multiprotein complexes, called inflammasomes, involved in the activation of pro-inflammatory caspases.
Fayyaz S, Sutterwala, Yasunori, Ogura, Dario S, Zamboni, Craig R, Roy, Richard A, Flavell   +4 more
openaire   +2 more sources