Results 51 to 60 of about 30,081,745 (303)

Activation of Caspase-1 in the Nucleus Requires Nuclear Translocation of Pro-caspase-1 Mediated by Its Prodomain [PDF]

Journal of Biological Chemistry, 1998
The interleukin-1beta-converting enzyme-like protease precursor, pro-caspase-1, has an N-terminal prodomain that is removed during cleavage activation of the protease. Here we show that tumor necrosis factor treatment of HeLa cells induced apoptosis without detectable proteolytic activation of caspase-1 in the cytosol.
Mao, P.-L., Jiang, Y., Wee, B.Y., Porter, A.G.   +3 more
openaire   +2 more sources

Inflammatory caspase substrate specificities

mBio
Caspases are a family of cysteine proteases that act as molecular scissors to cleave substrates and regulate biological processes such as programmed cell death and inflammation.
Patrick M. Exconde, Christopher M. Bourne, Madhura Kulkarni, Bohdana M. Discher, Cornelius Y. Taabazuing   +4 more
doaj   +1 more source

Role and Association of Inflammatory and Apoptotic Caspases in Renal Tubulointerstitial Fibrosis

Kidney & Blood Pressure Research, 2016
Background/Aims: Caspases, an evolutionary conserved family of aspartate-specific cystein proteases, play pivotal roles in apoptotic and inflammatory signaling.
You Ke, Hui Tang, Chen Ye, Chun-Tao Lei, Yu-Mei Wang, Hua Su, Chun Zhang, Hua-Jun Jiang   +7 more
doaj   +1 more source

Spotlight on pyroptosis: role in pathogenesis and therapeutic potential of ocular diseases

Journal of Neuroinflammation, 2022
Pyroptosis is a programmed cell death characterized by swift plasma membrane disruption and subsequent release of cellular contents and pro-inflammatory mediators (cytokines), including IL‐1β and IL‐18.
Meini Chen, Rong Rong, Xiaobo Xia
doaj   +1 more source

Roles of caspase-1 in Listeria infection in mice [PDF]

International Immunology, 2004
Caspase-1 [IL-1beta-converting enzyme (ICE)] processes substrate precursor molecules to yield the biologically active form of IL-1beta and IL-18, both of which are considered to play important roles in the host defense by activation of both innate and adaptive immunity.
Noriko M, Tsuji, Hiroko, Tsutsui, Ekihiro, Seki, Keisuke, Kuida, Haruki, Okamura, Kenji, Nakanishi, Richard A, Flavell   +6 more
openaire   +2 more sources

Caspase-1 activation during Eh-macrophage contact degrades cullin-1/5.

, 2021
(A, B) THP-1 derived macrophages were pre-incubated with the pan-caspase inhibitor Z-VAD-fmk (100μM) and caspase-1 specific inhibitor Z-YVAD-fmk (100μM) for 1 h followed by stimulation with Eh (10:1 ratio) for 10 min.
Kris Chadee (249039), Antoine Dufour (628454), Attinder Chadha (11414273), France Moreau (458493), Shanshan Wang (283009)   +4 more
core   +1 more source

Caspase-1 Modulates Incisional Sensitization and Inflammation [PDF]

Anesthesiology, 2010
Background Surgical injury induces production and release of inflammatory mediators in the vicinity of the wound. They in turn trigger nociceptive signaling to produce hyperalgesia and pain. Interleukin-1β plays a crucial role in this process.
De-Yong, Liang, XiangQi, Li, Wen-Wu, Li, Dennis, Fiorino, Yanli, Qiao, Peyman, Sahbaie, David C, Yeomans, J David, Clark   +7 more
openaire   +2 more sources

SfDredd directly cleaved Sf-caspase-1 in vitro.

, 2016
(A) Sf-caspase-1-C178A (300 nmol/L) was incubated with 300 nmol/L of C-terminally His-tagged SfDredd, SfDredd-C443A or SfDronc at 37°C for 1 h in Na-Citrate buffer and then subjected to immunoblotting using an antibody against Sf-caspase-1.
Andong Wu (201754), Long Mei (3179304), Zhouning Yang (201755), Ke Zhou (131917), Qingzhen Liu (321390), Hao Liu (12832)   +5 more
core   +1 more source

Caspase-11, a specific sensor for intracellular lipopolysaccharide recognition, mediates the non-canonical inflammatory pathway of pyroptosis

Cell & Bioscience, 2019
Pyroptosis, a type of programmed cell death that along with inflammation, is mainly regulated by two main pathways, cysteinyl aspartate specific proteinase (caspase)-1-induced canonical inflammatory pathway and caspase-11-induced non-canonical ...
Xiaoli Huang, Yang Feng, Guanqing Xiong, Shona Whyte, Jing Duan, Yucen Yang, Kaiyu Wang, Shiyong Yang, Yi Geng, Yangping Ou, Defang Chen   +10 more
doaj   +1 more source

Monocyte Caspase-1 Is Released in a Stable, Active High Molecular Weight Complex Distinct from the Unstable Cell Lysate-Activated Caspase-1. [PDF]

PLoS ONE, 2015
Mononuclear phagocytes utilize caspase-1 activation as a means to respond to danger signals. Although caspase-1 was discovered using highly concentrated cell extracts that spontaneously activate caspase-1, it is now clear that in live cell models caspase-
Obada R Shamaa, Srabani Mitra, Mikhail A Gavrilin, Mark D Wewers   +3 more
doaj   +1 more source