Results 11 to 20 of about 21,606,107 (313)

GSDMD-mediated pyroptosis restrains intracellular Chlamydia trachomatis growth in macrophages

Frontiers in Cellular and Infection Microbiology, 2023
Pyroptosis, a type of programmed necrosis associated with inflammatory, is a host defense mechanism against microbial infections. Although Chlamydia has been shown to induce pyroptosis, whether pyroptosis directly impacts the growth of Chlamydia has not ...
Ping Jiang, Hongzhi Chen, Xiaojing Feng, Huiqi Xie, Mengjie Jiang, Danning Xu, Haoneng Tang, Ningjie Zhang, Jianlin Chen, Lei Zhang, Lingli Tang   +10 more
doaj   +1 more source

Haplotypes of the Caspase-1 Gene, Plasma Caspase-1 Levels, and Cardiovascular Risk [PDF]

Circulation Research, 2006
Caspase-1 processes the interleukin (IL)-1β and IL-18 inactive precursors to the biologically active cytokines that are known to have proatherogenic effects. The present study investigated the genetic variability of the CASP1 gene and plasma levels of caspase-1 in relation to cardiovascular risk. In Europeans, 3 tag
Stefan, Blankenberg, Tiphaine, Godefroy, Odette, Poirier, Hans J, Rupprecht, Sandrine, Barbaux, Christoph, Bickel, Viviane, Nicaud, Renate, Schnabel, Frank, Kee, Caroline, Morrison, Alun, Evans, Karl J, Lackner, François, Cambien, Thomas, Münzel, Laurence, Tiret   +14 more
openaire   +2 more sources

Caspase-8 Potentiates Triglyceride (TG)-Induced Cell Death of THP-1 Macrophages via a Positive Feedback Loop

Korean Journal of Clinical Laboratory Science, 2021
Hypertriglyceridemia is the main risk factor for atherosclerosis. It is reported that triglyceride (TG) induces macrophage cell death, and is involved in the formation of plaques and development of atherosclerosis.
Byung Chul Jung, Jaewon Lim, Sung Hoon Kim, Yoon Suk Kim   +3 more
doaj   +1 more source

RAB39a binds caspase-1 and is required for caspase-1-dependent interleukin-1β secretion. [PDF]

Journal of Biological Chemistry, 2009
Interleukin-1beta (IL-1beta) is an important pro-inflammatory cytokine that is secreted by unconventional means in a caspase-1-dependent manner. Using a one-step immunoprecipitation approach to isolate endogenous caspase-1 from the monocytic THP1 cell line, we identified previously undescribed binding partners using mass spectrometry.
Becker, Christine E., Creagh, Emma M., O'Neill, Luke A. J.   +2 more
openaire   +4 more sources

An Apoptotic Caspase Network Safeguards Cell Death Induction in Pyroptotic Macrophages

Cell Reports, 2020
Summary: Pyroptosis has emerged as a key mechanism by which inflammasomes promote host defense against microbial pathogens and sterile inflammation. Gasdermin D (GSDMD)-mediated cell lysis is a hallmark of pyroptosis, but our understanding of cell death ...
Nathalia Moraes de Vasconcelos, Nina Van Opdenbosch, Hanne Van Gorp, Rosa Martín-Pérez, Annalisa Zecchin, Peter Vandenabeele, Mohamed Lamkanfi   +6 more
doaj   +1 more source

A Role for Caspase-1 in Heart Failure [PDF]

Circulation Research, 2007
Apoptosis of cardiomyocytes is increased in heart failure and has been implicated in disease progression. The activation of “proapoptotic” caspases represents a key step in cardiomyocyte apoptosis. In contrast, the role of “proinflammatory” caspases (caspases 1, 4, 5, 11, 12) is unclear. Here, we study the cardiac function of caspase-1.
Sabine, Merkle, Stefan, Frantz, Michael P, Schön, Johann, Bauersachs, Monika, Buitrago, Robert J A, Frost, Eva M, Schmitteckert, Martin J, Lohse, Stefan, Engelhardt   +8 more
openaire   +2 more sources

Expression of caspase-3, caspase-9, GDF-9 and IGF-1 genes in ovine oocytes cultured with optimum and elevated doses of Amphiregulin, Neuregulin-1 and Tumour necrosis factor-α in-vitro

Indian Journal of Animal Sciences, 2022
The present study was conducted to evaluate the expression of caspase-3, caspase-9, growth differentiation factor-9 (GDF-9) and insulin growth factor-1 (IGF-1) genes in oocytes cultured in vitro with optimum and elevated doses of amphiregulin (50 ng and
RAMESH HONDARAVALLI SOMASHETTY, NANDI SUMANTA, GIRISH KUMAR VENKATESH   +2 more
doaj   +1 more source

Neutrophil Caspase-11 Is Essential to Defend against a Cytosol-Invasive Bacterium

Cell Reports, 2020
Summary: Either caspase-1 or caspase-11 can cleave gasdermin D to cause pyroptosis, eliminating intracellular replication niches. We previously showed that macrophages detect Burkholderia thailandensis via NLRC4, triggering the release of interleukin (IL)
Stephen B. Kovacs, Changhoon Oh, Vivien I. Maltez, Benjamin D. McGlaughon, Ambika Verma, Edward A. Miao, Youssef Aachoui   +6 more
doaj   +1 more source

Specific NLRP3 Inflammasome Assembling and Regulation in Neutrophils: Relevance in Inflammatory and Infectious Diseases

Cells, 2022
The NLRP3 inflammasome is a cytosolic multimeric protein platform that leads to the activation of the protease zymogen, caspase-1 (CASP1). Inflammasome activation mediates the proteolytic activation of pro-inflammatory cytokines (IL-1β and IL-18) and ...
Christophe Paget, Emilie Doz-Deblauwe, Nathalie Winter, Benoit Briard   +3 more
doaj   +1 more source

Anti-GBM glomerulonephritis involves IL-1 but is independent of NLRP3/ASC inflammasome-mediated activation of caspase-1 [PDF]

, 2011
IL-1b and IL-18 are proinflammatory cytokines that contribute to renal immune complex disease, but whether IL-1b and IL-18 are mediators of intrinsic glomerular inflammation is unknown.
Volker Vielhauer, Clemens D Cohen, Vielhauer, V, Lichtnekert Julia, Dan Muruve, Shrikant R. Mulay, Muruve, D, Ramanjaneyulu Allam, Maja T. Lindenmeyer, Lichtnekert, Julia, Hans-Joachim Anders, Lindenmeyer, M T, Cohen Clemens D., Kulkarni, Onkar P., Vielhauer, Volker, Muruve Dan, Kulkarni Onkar P., Maja T Lindenmeyer, Cohen, Clemens D., Ryu, Mi, Rupanagudi Khader Valli, Ryu Mi, Khader Valli Rupanagudi, Mulay Shrikant R., Ryu, M, Lindenmeyer, Maja T., Anders Hans-Joachim, Clemens D. Cohen, Cohen, C D, Onkar P Kulkarni, Shrikant R Mulay, Allam, R, Allam Ramanjaneyulu, Vielhauer Volker, Muruve, Dan, Rupanagudi, Khader Valli, Anders, Hans-Joachim, Mi Ryu, Lichtnekert, J, Mulay, Shrikant R., Allam, Ramanjaneyulu, Julia Lichtnekert, Lindenmeyer Maja T., Rupanagudi, K V, Mulay, S R, Kulkarni, O P, Anders, H J, Onkar P. Kulkarni   +47 more
core   +1 more source