Results 11 to 20 of about 329,630 (269)
An Allosteric Circuit in Caspase-1 [PDF]
Journal of Molecular Biology, 2008 Structural studies of caspase-1 reveal that the dimeric thiol protease can exist in two states: in an on-state, when the active site is occupied, or in an off-state, when the active site is empty or when the enzyme is bound by a synthetic allosteric ligand at the dimer interface approximately 15 A from the active site.
Debajyoti, Datta +3 more
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Caspase-1: The inflammasome and beyond [PDF]
Innate Immunity, 2013 Caspase-1 plays a fundamental role in innate immunity and in several important inflammatory diseases as the protease activates the pro-inflammatory cytokines proIL-1β and proIL-18. Caspase-1 itself is activated in different inflammasome complexes, which assemble in response to a variety of exogenous and endogenous stressors.
Sollberger, Gabriel +4 more
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Haplotypes of the Caspase-1 Gene, Plasma Caspase-1 Levels, and Cardiovascular Risk [PDF]
Circulation Research, 2006 Caspase-1 processes the interleukin (IL)-1β and IL-18 inactive precursors to the biologically active cytokines that are known to have proatherogenic effects. The present study investigated the genetic variability of the CASP1 gene and plasma levels of caspase-1 in relation to cardiovascular risk. In Europeans, 3 tag
Stefan, Blankenberg +14 more
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RAB39a binds caspase-1 and is required for caspase-1-dependent interleukin-1β secretion. [PDF]
Journal of Biological Chemistry, 2009 Interleukin-1beta (IL-1beta) is an important pro-inflammatory cytokine that is secreted by unconventional means in a caspase-1-dependent manner. Using a one-step immunoprecipitation approach to isolate endogenous caspase-1 from the monocytic THP1 cell line, we identified previously undescribed binding partners using mass spectrometry.
Becker, Christine E. +2 more
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An Apoptotic Caspase Network Safeguards Cell Death Induction in Pyroptotic Macrophages
Cell Reports, 2020 Summary: Pyroptosis has emerged as a key mechanism by which inflammasomes promote host defense against microbial pathogens and sterile inflammation. Gasdermin D (GSDMD)-mediated cell lysis is a hallmark of pyroptosis, but our understanding of cell death ...
Nathalia Moraes de Vasconcelos +6 more
doaj +1 more source
A Role for Caspase-1 in Heart Failure [PDF]
Circulation Research, 2007 Apoptosis of cardiomyocytes is increased in heart failure and has been implicated in disease progression. The activation of “proapoptotic” caspases represents a key step in cardiomyocyte apoptosis. In contrast, the role of “proinflammatory” caspases (caspases 1, 4, 5, 11, 12) is unclear. Here, we study the cardiac function of caspase-1.
Sabine, Merkle +8 more
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Neutrophil Caspase-11 Is Essential to Defend against a Cytosol-Invasive Bacterium
Cell Reports, 2020 Summary: Either caspase-1 or caspase-11 can cleave gasdermin D to cause pyroptosis, eliminating intracellular replication niches. We previously showed that macrophages detect Burkholderia thailandensis via NLRC4, triggering the release of interleukin (IL)
Stephen B. Kovacs +6 more
doaj +1 more source
Caspase-1 inflammasomes in infection and inflammation [PDF]
Journal of Leukocyte Biology, 2007 AbstractNucleotide-binding and oligomerization domain-like receptors (NLRs) constitute a family of germline-encoded pattern-recognition receptors, which allow the host to respond rapidly to a wide variety of pathogenic microorganisms. Here, we discuss recent advances in the study of a subset of NLRs, which control the activation of caspase-1 through ...
Lamkanfi, Mohamed +3 more
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Journal of Integrative Neuroscience, 2023 Introduction: Some studies have found that probiotics can improve cognitive impairment in Alzheimer’s disease, although the specific molecular mechanism by which this occurs has not been reported.
Xue-Qin Yang +6 more
doaj +1 more source
Thalidomide Inhibits Activation of Caspase-1 [PDF]
The Journal of Immunology, 2009 Abstract Thalidomide is an efficient anti-inflammatory and anti-angiogenic drug, but its therapeutic use is problematic due to a strong teratogenic activity. Nevertheless, thalidomide was approved for the treatment of inflammatory skin diseases and certain types of cancer, and it is extensively tested for several other indications ...
Keller, Martin +2 more
openaire +4 more sources