Results 21 to 30 of about 318,537 (297)
Journal of Integrative Neuroscience, 2023 Introduction: Some studies have found that probiotics can improve cognitive impairment in Alzheimer’s disease, although the specific molecular mechanism by which this occurs has not been reported.
Xue-Qin Yang +6 more
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Nedd8 Regulates Inflammasome-Dependent Caspase-1 Activation [PDF]
Molecular and Cellular Biology, 2015 Caspase-1 is activated by the inflammasome complex to process cytokines like interleukin-1β (IL-1β). Pro-caspase-1 consists of three domains, CARD, p20, and p10. Association of pro-caspase-1 with the inflammasome results in initiation of its autocatalytic activity, culminating in self-cleavage that generates catalytically active subunits (p10 and p20).
Segovia, Jesus A +6 more
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iScience, 2023 Summary: Canonical pyroptosis is type of programmed cell death depending on active caspase-1, and the inflammasome carries out caspase-1 activation. Here, we showed that docosahexaenoic acid (DHA) induced ovarian cancer cell deaths in caspase-1-dependent
Ozlem Calbay +9 more
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Caspase-1 inflammasomes in infection and inflammation [PDF]
Journal of Leukocyte Biology, 2007 AbstractNucleotide-binding and oligomerization domain-like receptors (NLRs) constitute a family of germline-encoded pattern-recognition receptors, which allow the host to respond rapidly to a wide variety of pathogenic microorganisms. Here, we discuss recent advances in the study of a subset of NLRs, which control the activation of caspase-1 through ...
Lamkanfi, Mohamed +3 more
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Caspase-1 Modulates Incisional Sensitization and Inflammation [PDF]
Anesthesiology, 2010 Background Surgical injury induces production and release of inflammatory mediators in the vicinity of the wound. They in turn trigger nociceptive signaling to produce hyperalgesia and pain. Interleukin-1β plays a crucial role in this process.
De-Yong, Liang +7 more
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Caspase-1 Mediates Resistance in Murine Melioidosis [PDF]
Infection and Immunity, 2009 ABSTRACT The gram-negative rod Burkholderia pseudomallei is the causative agent of melioidosis, a potentially fatal disease which is endemic in tropical and subtropical areas. The bacterium multiplies intracellularly within the cytosol, induces the formation of actin tails, and can spread directly from ...
Breitbach, K. +8 more
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Cell Reports, 2017 Inflammasomes activate the protease caspase-1, which cleaves interleukin-1β and interleukin-18 to generate the mature cytokines and controls their secretion and a form of inflammatory cell death called pyroptosis.
Katharina S. Schneider +16 more
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Alpha 1-antitrypsin does not inhibit human monocyte caspase-1. [PDF]
PLoS ONE, 2015 BACKGROUND:Alpha 1-antitrypsin (A1AT) is a 52 kDa serine protease inhibitor produced largely by hepatocytes but also by mononuclear phagocytes. A1AT chiefly inhibits neutrophil elastase and proteinase-3 but has also been reported to have immune ...
Mohd Akhlakur Rahman +3 more
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Role and Association of Inflammatory and Apoptotic Caspases in Renal Tubulointerstitial Fibrosis
Kidney & Blood Pressure Research, 2016 Background/Aims: Caspases, an evolutionary conserved family of aspartate-specific cystein proteases, play pivotal roles in apoptotic and inflammatory signaling.
You Ke +7 more
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Monocyte Caspase-1 Is Released in a Stable, Active High Molecular Weight Complex Distinct from the Unstable Cell Lysate-Activated Caspase-1. [PDF]
PLoS ONE, 2015 Mononuclear phagocytes utilize caspase-1 activation as a means to respond to danger signals. Although caspase-1 was discovered using highly concentrated cell extracts that spontaneously activate caspase-1, it is now clear that in live cell models caspase-
Obada R Shamaa +3 more
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