Results 21 to 30 of about 24,095,126 (372)
Pyroptosis: A Common Feature of Immune Cells of Haemodialysis Patients
Toxins, 2021 NLRP-3 inflammasome activation can result in interleukin-1β (IL-1β) release and inflammatory cell death (pyroptosis). Caspase-1 is able to trigger both processes.
Christof Ulrich +10 more
doaj +1 more source
RAB39a binds caspase-1 and is required for caspase-1-dependent interleukin-1β secretion. [PDF]
Journal of Biological Chemistry, 2009 Interleukin-1beta (IL-1beta) is an important pro-inflammatory cytokine that is secreted by unconventional means in a caspase-1-dependent manner. Using a one-step immunoprecipitation approach to isolate endogenous caspase-1 from the monocytic THP1 cell line, we identified previously undescribed binding partners using mass spectrometry.
Christine Becker +2 more
openaire +5 more sources
GSDMD-mediated pyroptosis restrains intracellular Chlamydia trachomatis growth in macrophages
Frontiers in Cellular and Infection Microbiology, 2023 Pyroptosis, a type of programmed necrosis associated with inflammatory, is a host defense mechanism against microbial infections. Although Chlamydia has been shown to induce pyroptosis, whether pyroptosis directly impacts the growth of Chlamydia has not ...
Ping Jiang +10 more
doaj +1 more source
Cancers, 2020 Trillium tschonoskii Maxim (TTM), a traditional Chinese medicine, has been demonstrated to have a potent anti-tumor effect. Recently, polyphyllin VI (PPVI), a main saponin isolated from TTM, was reported by us to significantly suppress the proliferation ...
Jin-Feng Teng +15 more
semanticscholar +1 more source
YopM Puts Caspase-1 on Ice [PDF]
Cell Host & Microbe, 2012 Caspase-1-mediated detection of pathogens is a potent arm of the innate immune system. LaRock and Cookson (2012) show that the Yersinia type III secretion effector, YopM, directly inhibits caspase-1.
Edward A. Miao, Ine Jorgensen
openaire +3 more sources
Caspase-1 as a regulatory molecule of lipid metabolism [PDF]
Lipids in Health and Disease, 2020 AbstractCaspase-1 is an evolutionarily conserved inflammatory mediated enzyme that cleaves and activates inflammatory cytokines. It can be activated through the assembly of inflammasome and its major effect is to activate the pro-inflammatory cytokines; interleukin 1β (IL-1β) and interluekine-18 (IL-18).
Tesfahun Dessale Admasu +4 more
openaire +3 more sources
Korean Journal of Clinical Laboratory Science, 2021 Hypertriglyceridemia is the main risk factor for atherosclerosis. It is reported that triglyceride (TG) induces macrophage cell death, and is involved in the formation of plaques and development of atherosclerosis.
Byung Chul Jung +3 more
doaj +1 more source
PM2.5‐induced pulmonary inflammation via activating of the NLRP3/caspase‐1 signaling pathway
Environmental Toxicology, 2020 Particulate matter 2.5 (PM2.5)‐induced pulmonary inflammation has become a public concern in recent years. In which, the activation of the NLRP3/caspase‐1 pathway was closely related to the inflammatory response of various diseases.
Hui Jia +5 more
semanticscholar +1 more source
Thalidomide Inhibits Activation of Caspase-1 [PDF]
The Journal of Immunology, 2009 Abstract Thalidomide is an efficient anti-inflammatory and anti-angiogenic drug, but its therapeutic use is problematic due to a strong teratogenic activity. Nevertheless, thalidomide was approved for the treatment of inflammatory skin diseases and certain types of cancer, and it is extensively tested for several other indications ...
Keller, Martin +2 more
openaire +4 more sources
A Role for Caspase-1 in Heart Failure [PDF]
Circulation Research, 2007 Apoptosis of cardiomyocytes is increased in heart failure and has been implicated in disease progression. The activation of “proapoptotic” caspases represents a key step in cardiomyocyte apoptosis. In contrast, the role of “proinflammatory” caspases (caspases 1, 4, 5, 11, 12) is unclear. Here, we study the cardiac function of caspase-1.
Sabine Merkle +8 more
openaire +3 more sources