Results 241 to 250 of about 16,586,228 (338)

Macrophage‐Mediated Transport of Insoluble Indirubin Induces Hepatic Injury During Intestinal Inflammation

Advanced Science, EarlyView.
Plant‐derived bioactive molecules with low solubility and permeability induce hepatocyte injury, though the mechanisms driving their hepatic effects remain poorly understood. This study identifies a novel transport pathway in which poorly soluble indirubin accumulates in the liver via macrophage‐mediated uptake in Peyer's patches, exacerbating hepatic ...
Yiqi Xu, Jingchun Shi, Heung‐Lam Mok, Cheng Lyu, Junbang Chen, Chunhua Huang, Hongyan Qin, Chengyuan Lin, Hor‐Yue Tan, Zhaoxiang Bian   +9 more
wiley   +1 more source

Caspase 3/GSDME-Mediated Corneal Epithelial Pyroptosis Promotes Dry Eye Disease. [PDF]

Invest Ophthalmol Vis Sci
Wang L, Tian Y, Zhang H, Dong Y, Hua X, Yuan X.   +5 more
europepmc   +1 more source

Parvalbumin Interneuron‐Dependent Hippocampal Neurogenesis Evoked by Prolonged Rhythmic Light Flicker

Advanced Science, EarlyView.
This study demonstrates that prolonged rhythmic 40 Hz light flicker enhances spatial learning by stimulating PV interneuron‐dependent neurogenesis. The light flicker selectively activates PV interneurons, which enhances GABAergic support for the integration of immature neurons in the adult dentate gyrus.
Hai Yan, Yunxuan Wang, Xufan Deng, Shiyu Wu, Yifan Pan, Jun Du, Mei Yu, Bo Liu, Huimei Wang, Zhengyu Zhang, Jinghong Chen, Shuifa Chen, Yizheng Wang, Tara Walker, Perry Bartlett, Jun Ju, Sheng‐Tao Hou   +16 more
wiley   +1 more source

Correction: The absence of Pitx3 results in postnatal loss of dopamine neurons and is associated with an increase in the pro-apoptotic Bcl2 factor Noxa and cleaved caspase 3. [PDF]

Cell Death Dis
Kouwenhoven WM, Robinson EJ, Hamberg D, von Oerthel L, Smidt MP, van der Heide LP.   +5 more
europepmc   +1 more source

DFF, a Heterodimeric Protein That Functions Downstream of Caspase-3 to Trigger DNA Fragmentation during Apoptosis

Cell, 1997
X. Liu, Hua Zou, C. Slaughter, Xiaodong Wang   +3 more
semanticscholar   +1 more source

Local Visible‐Photocatalytic Production of Hydrogen and Warm Heat for Combination Treatment of Pressure Ulcer

Advanced Science, EarlyView.
A novel concept of visible‐photocatalytic hydrogen/warm heat production is proposed for combination treatment of pressure ulcer (PU), and develop a new kind of palladium nanodots‐deposited hydrogen‐doped titanium dioxide nanorods encapsulating hydorgel dressing to receive a high outcome of PU treatment by hydrogen/warm heat synergistically improving ...
Jiawei Zhu, Ting Chen, Wei Fang, Di Zhou, Dalong Ni, Bin Zhao, Yali Yang, Zhuobin Xu, Qianjun He   +8 more
wiley   +1 more source

Oxypeucedanin alleviates cisplatin-induced intestinal toxicity through impairing caspase-3/gasdermin E signaling. [PDF]

J Vet Med Sci
Wang R, Gao F, Hao L, Zhang J, Chen Z, Song D, Gao F, He W, Zhao K, Guan J.   +9 more
europepmc   +1 more source

Splicing Shift of RAC1 Accelerates Tumorigenesis and Defines a Potent Therapeutic Target in Lung Cancer

Advanced Science, EarlyView.
Dysregulated RNA splicing is an underappreciated molecular feature of cancer. By integrating murine and cellular models with patient specimens of lung adenocarcinoma, this study demonstrates that RAC1B, rather than RAC1A isoform, promotes tumorigenesis and presents a potent therapeutic target for lung cancer. Mechanistically, RAC1B preferentially binds
Yueren Yan, Ning Wang, Bowen Xing, Min Yang, Jun Shang, Yufang Bao, Lixing Xiao, Ningxia Zhang, Yunpeng Ren, Chunnan Liu, Yuting Chen, Han Han, Yunjian Pan, Lei Lv, Wei‐Xing Zong, Hongbin Ji, Changyou Zhan, Zefeng Wang, Haiquan Chen, Yongbo Wang   +19 more
wiley   +1 more source

Inhibition of Caspase-3/GSDME Pathway-Mediated Pyroptosis of Renal Tubular Epithelial Cells by Dagliflozin in the Pathogenesis of Diabetic Kidney Disease and Study of Its Mechanism. [PDF]

Diabetes Metab Syndr Obes
Jiang H, Gao M, Liu J, Yang L, Liu L.
europepmc   +1 more source

Ectromelia virus virulence factor p28 acts upstream of caspase-3 in response to UV light-induced apoptosis

, 2000
David J. Brick, Chris Upton, Aaron A. Minkley, Robert D. Burke   +3 more
openalex   +1 more source