Results 101 to 110 of about 12,127,416 (284)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Infection-generated electric field in gut epithelium drives bidirectional migration of macrophages. [PDF]

, 2019
Many bacterial pathogens hijack macrophages to egress from the port of entry to the lymphatic drainage and/or bloodstream, causing dissemination of life-threatening infections. However, the underlying mechanisms are not well understood.
Ferreira, Fernando, Guo, Betty P, Lebrilla, Carlito B, Lokken, Kristen L, Luxardi, Guillaume, Ma, Li, Maverakis, Emanual, Mogilner, Alex, Reid, Brian, Ryzhuk, Volodymyr, Sun, Yaohui, Sun, Yuxin, Xu, Gege, Zhao, Min, Zhu, Kan   +14 more
core   +2 more sources

Endoplasmic reticulum stress-induced caspase-4 activation mediates apoptosis and neurodegeneration in INCL [PDF]

Human Molecular Genetics, 2006
Infantile neuronal ceroid lipofuscinosis (INCL), a neurodegenerative storage disorder of childhood, is caused by mutations in the palmitoyl-protein thioesterase-1 (PPT1) gene. PPT1 cleaves thioester linkages in S-acylated (palmitoylated) proteins and its mutation causes abnormal intracellular accumulation of fatty-acylated proteins and peptides leading
Sung-Jo, Kim, Zhongjian, Zhang, Emiko, Hitomi, Yi-Ching, Lee, Anil B, Mukherjee   +4 more
openaire   +2 more sources

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Caspase-11-Gasdermin D-Mediated Pyroptosis Is Involved in the Pathogenesis of Atherosclerosis

Frontiers in Pharmacology, 2021
Background: Pyroptosis is a form of cell death triggered by proinflammatory signals. Recent studies have reported that oxidized phospholipids function as caspase-11 agonists to induce noncanonical inflammasome activation in immune cells. As the levels of
Mengqing Jiang, Xuejing Sun, Suzhen Liu, Yan Tang, Yunming Shi, Yuanyuan Bai, Yujie Wang, Qiong Yang, Qize Yang, Weihong Jiang, Hong Yuan, Qixia Jiang, Jingjing Cai, Jingjing Cai   +13 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Anti-inflammatory effect of cinnamaldehyde in a mouse model of 2,4-dinitrofluorobenzene-induced atopic dermatitis

Indian Journal of Dermatology, 2023
Background: This study aims to investigate the anti-inflammatory effects of cinnamaldehyde in atopic dermatitis (AD) in the mouse model. Materials and Methods: Twenty-four mice were divided into four groups: Group A (control), group B [AD with no ...
Eda Ustaoglu, Zafer Turkoglu, Ovgu A Ulgen, Ceyda Caytemel, Senay Agirgol   +4 more
doaj   +1 more source

A genome‐wide screen identifies IRF2 as a key regulator of caspase‐4 in human cells

EMBO Reports, 2019
Caspase‐4, the cytosolic LPS sensor, and gasdermin D, its downstream effector, constitute the non‐canonical inflammasome, which drives inflammatory responses during Gram‐negative bacterial infections.
Sacha Benaoudia, Amandine Martin, Marta Puig Gámez, Gabrielle Gay, Brice Lagrange, M. Cornut, Kyrylo Krasnykov, J. Claude, Cyril F. Bourgeois, S. Hughes, B. Gillet, O. Allatif, A. Corbin, R. Ricci, T. Henry   +14 more
semanticscholar   +1 more source

Noncanonical Roles of Caspase-4 and Caspase-5 in Heme-Driven IL-1β Release and Cell Death

Journal of Immunology, 2020
Key Points Heme induces oligomerization of caspase-1, caspase-4, and caspase-5. Heme-induced IL-1β release requires both caspase-4 and caspase-5. Caspase-4 is the primary effector of heme-induced cell death. Visual Abstract Excessive release of heme from
B. Bolívar, Alexandra N. Brown-Suedel, B. Rohrman, Chloé I. Charendoff, Vanda Yazdani, J. Belcher, G. Vercellotti, Jonathan M. Flanagan, L. Bouchier-Hayes   +8 more
semanticscholar   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source