Results 141 to 150 of about 12,127,416 (284)

Genomic Control of Upregulation of GRP78 Expression for Promotion of Neurite Elongation and Attenuation of Cell Death via PKA-Mediated Signaling in PC12 Cells [PDF]

, 2015
Neurodegeneration occurs due to neuronal cell death and subsequently disrupts neuronal networks. In current medicine, methods for interruption of neuronal cell death and avoidance of disruption of neuronal networks have potential as therapy for ...
Aoyama Hiroki, Nakagawa Kazuma, Nishihata Yoshiki, Shimoke Koji, Yamazoe Ryosuke, 下家 浩二, 中川 一馬, 山添 亮輔, 西畑 慶紀, 青山 大輝   +9 more
core   +2 more sources

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Integrins engage mitochondrial function for signal transduction by a mechanism dependent on Rho GTPases. [PDF]

, 2002
We show here the transient activation of the small GTPase Rac, followed by a rise in reactive oxygen species (ROS), as necessary early steps in a signal transduction cascade that lead to NFkappaB activation and collagenase-1 (CL-1)/matrix ...
Werb, Zena, Werner, Erica
core  

NCLs and ER: A stressful relationship. [PDF]

, 2017
The Neuronal Ceroid Lipofuscinoses (NCLs, Batten disease) are a group of inherited neurodegenerative disorders with variable age of onset, characterized by the lysosomal accumulation of autofluorescent ceroid lipopigments.
Marotta, D, Mole, SE, Tinelli, E
core   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

The cytoskeleton in cell-autonomous immunity: structural determinants of host defence

, 2015
Host cells use antimicrobial proteins, pathogen-restrictive compartmentalization and cell death in their defence against intracellular pathogens. Recent work has revealed that four components of the cytoskeleton — actin, microtubules, intermediate ...
A Ablasser, A Akhter, A Desai, A Fukazawa, A Stolz, AB Jaffe, AF Frade, AJ Thrasher, AL Waite, AM Keestra, AP West, AR Shenoy, Avinash R. Shenoy, B Levine, B-H Kim, BB Mishra, BT Kile, C Stevens, C Watts, CM Haglund, CS Weirich, D Chen, D Ghosal, D Parker, D Sancho, DC Rubinsztein, DJ Philpott, DL Clemens, DM Underhill, E Bi, E Caron, EL Benanti, F Caudron, F Martinon, F Randow, F Randow, F Rees, G Bonizzi, G dos Santos, G Kuhlenbaumer, G Tran Van Nhieu, H Bielig, H Herrmann, H Sridharan, H Xu, HB Yu, HS Goodridge, I Monastyrska, IM Dambuza, J Eitel, J Huang, J Jin, J Li, J Li, J Pizarro-Cerdá, J Saarikangas, J Shi, J von Moltke, J-G Zhang, JA Hagar, JA Swanson, JC Kagan, JCH Tam, JD MacMicking, JJ Bravo-Cordero, JL Dangl, JP Solomon, JR Terman, JS Hyams, JSC Arthur, JW Jones, K Aktories, K Aktories, K Dobbs, K Gotoh, KL Angus, L Blanchoin, L Kong, L Le Bourhis, LA Cameron, LA Knodler, LJF Jones, M Kokes, M Lamkanfi, M Ogawa, M Ogawa, M Pasparakis, M Rosas, M Sasai, M Yoneyama, MA Al-Zeer, MA Gavrilin, MA Gavrilin, MA Gavrilin, MA Sanjuan, MB Torchinsky, MD Welch, MJG Eldridge, ML Kim, MT Cabeen, N Ausmees, N Carayol, N Kayagaki, N Kayagaki, N Mizushima, N Ostler, N Schroeder, N Subramanian, NE Harwood, NT Snider, P Cossart, P Hanc, P Wild, P Xia, PS Manzanillo, R Goldbach-Mansky, R Mackeh, R Muñoz-Planillo, RC Wang, RE Vance, S Ahrens, S Asrat, S Iborra, S Legrand-Poels, S Mostowy, S Mostowy, S Mostowy, S Mostowy, S Mostowy, S Mostowy, S Mostowy, S Mostowy, S Park, S Savic, S Zelenay, SA Schattgen, SCO Reed, Serge Mostowy, SL Sandiford, SM Man, T Fernandes-Alnemri, T Kawai, T Misawa, T Strowig, T Tamura, TA Kufer, TD Pollard, TLM Thurston, U Golebiewska, V Deretic, VAK Rathinam, VAK Rathinam, W-D Hardt, WA McEwan, WM Schneider, X Cai, Y Aachoui, Y Aachoui, Y Kumar, Y Ma, Y Song, Y Tanaka-Takiguchi, Y Yoshikawa, Y Zhao, Y-W Huang, YT Zheng   +165 more
core   +1 more source

Global analysis of gene expression in NGF-deprived sympathetic neurons identifies molecular pathways associated with cell death [PDF]

, 2011
Developing sympathetic neurons depend on nerve growth factor (NGF) for survival and die by apoptosis after NGF withdrawal. This process requires de novo gene expression but only a small number of genes induced by NGF deprivation have been identified so ...
A Eilers, A Nishiyama, A Wyttenbach, B Conradt, CG Besirli, D Lindholm, DG Breckenridge, DP Martin, E Junn, E Towers, EA Lipscomb, EV Maytin, Francesca Menghi, GK Smyth, GV Putcha, GV Putcha, H Puthalakath, H Zinszner, I Lassot, J Gilley, J Ham, J Nordberg, J Whitfield, J Whitfield, J Whitfield, J Yuan, JL Franklin, Jonathan Ham, K Imaizumi, K Mayumi-Matsuda, K Virdee, K Wartiovaara, KJ Livak, KM Wright, KZ Guyton, M Deshmukh, M Kristiansen, M Mota, M Palmada, Mark Kristiansen, MD Jacobson, MI Smith, Mike Hubank, MJ Prieto-Alamo, N Ohoka, N Schreiber-Agus, O Delpuech, R Hughes, R Hughes, RA Kirkland, Rosie Hughes, RR Buss, RS Freeman, RV Rao, RW Oppenheim, S Desagher, S Estus, S Kojima, S Schlisio, SJ Neame, SN Edwards, T Bishop, T Gotoh, TC Harding, TL Deckwerth, W Huang da, WB Jacobs, X Jiang, Z Galehdar, Z Xu   +69 more
core   +4 more sources

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Инфламмасомы и пироптоз эпителиальных клеток кишечника: вклад в развитие болезни Крона и неспецифического язвенного колита [PDF]

, 2019
ИНФЛАММАСОМЫПИРОПТОЗКЛЕТКИ СМЕРТЬЭПИТЕЛИОЦИТЫЭПИТЕЛИАЛЬНЫЕ КЛЕТКИКИШЕЧНИКА ВОСПАЛИТЕЛЬНЫЕ БОЛЕЗНИКРОНА БОЛЕЗНЬИЛЕИТ РЕГИОНАЛЬНЫЙИЛЕИТ ТЕРМИНАЛЬНЫЙИЛЕОКОЛИТЭНТЕРИТ ГРАНУЛОМАТОЗНЫЙКОЛИТ ЯЗВЕННЫЙПРОКТОКОЛИТ ЯЗВЕННЫЙПРОКТОЛИТ ГЕМОРРАГИЧЕСКИЙРЕКТОКОЛИТ ...
Ткаченко, А. С.
core   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source