Results 261 to 270 of about 12,127,416 (284)

Recognition and maturation of IL-18 by caspase-4 noncanonical inflammasome

Nature, 2023
The canonical (caspase-1) and noncanonical (comprising caspases 4, 5 and 11; hereafter, caspase-4/5/11) inflammasomes both cleave gasdermin D (GSDMD) to induce pyroptosis1,2. Whereas caspase-1 processes IL-1β and IL-18 for maturation3-6, no cytokine target has been firmly established for lipopolysaccharide-activated caspase-4/5/117-9. Here we show that
Xuyan Shi, Qichao Sun, Yanjie Hou, Huan Zeng, Yong Cao, Mengqiu Dong, Jingjin Ding, Feng Shao   +7 more
openaire   +3 more sources

Mitochondrial calpain-5 truncates caspase-4 during endoplasmic reticulum stress

Biochemical and Biophysical Research Communications, 2022
Calpains are cysteine proteases activated in response to intracellular calcium signaling. Activated calpains regulate various cellular functions by degrading substrate molecules in a site-specific manner. Although most calpains are localized in the cytosol, we previously reported that calpain-5 exists in the mitochondria. The mitochondrial calpain-5 is
Yusaku Chukai, Ginga Ito, Masahide Konno, Yuri Sakata, Taku Ozaki   +4 more
openaire   +2 more sources

Caspase-4 Activation and Recruitment to Intracellular Gram-Negative Bacteria

2023
The non-canonical inflammasome pathway functions as the primary cytosolic innate immune detection mechanism for Gram-negative bacterial lipopolysaccharide (LPS) in human and mouse cells and controls the proteolytic activation of the cell death executor gasdermin D (GSDMD). The main effectors of this pathways are the inflammatory proteases caspase-11 in
Marisa, Dilucca, Petr, Broz
openaire   +2 more sources

Caspase‐4/11 is critical for angiogenesis by repressing Notch1 signalling via inhibiting γ‐secretase activity

British Journal of Pharmacology, 2022
Notch1 activation mediated by γ‐secretase is critical for angiogenesis. GeneCards database predicted that Caspase‐4 (CASP4, with murine ortholog CASP11) interacts with presenilin‐1, the catalytic core of γ‐secretase.
Linlin Fan, Hao Liu, G. Zhu, Shekhar Singh, Ze Yu, Shumin Wang, Hong Luo, Shiying Liu, Yawei Xu, J. Ge, Dongyang Jiang, Jinjiang Pang   +11 more
semanticscholar   +1 more source

A significant other: Non‐canonical caspase‐4/5/11 inflammasome in periodontitis

Oral Diseases, 2022
AbstractPeriodontitis is an oral inflammatory disease characterised by the destruction of periodontal soft tissue and alveolar bone resorption, mainly triggered by plaque microbial infection. Pyroptosis is an inflammatory form of programmed cell death mediated by the pore‐forming gasdermin proteins, which resist the invasion of pathogens into the body ...
Zizheng Wang, Weicheng Chan, Yuan Yue
openaire   +2 more sources

Both dimerization and interdomain processing are essential for caspase-4 activation

Biochemical and Biophysical Research Communications, 2007
A subgroup of caspase family of inflammatory caspases (-1, -4, -5, -11, and -12) play important role during cytokine maturation and inflammation but their regulation is not well understood as much as the initiator and effector caspases. Here, the biochemical mechanism of caspase-4 activation is elucidated.
Pratap, Karki, Giri Raj, Dahal, Il-Seon, Park   +2 more
openaire   +2 more sources

TRAIL-induced apoptosis of human melanoma cells involves activation of caspase-4

Apoptosis, 2010
Although it is conventionally regarded as an inflammatory caspase, recent studies have shown that caspase-4 plays a role in induction of apoptosis by endoplasmic reticulum (ER) stress. We report here that activation of caspase-4 is also involved in induction of apoptosis by TNF-related apoptosis-inducing ligand (TRAIL) in human melanoma cells ...
Zhi Gang, Mao, Chen Chen, Jiang, Fan, Yang, Rick F, Thorne, Peter, Hersey, Xu Dong, Zhang   +5 more
openaire   +2 more sources

α‐NETA induces pyroptosis of epithelial ovarian cancer cells through the GSDMD/caspase‐4 pathway

The FASEB Journal, 2019
Chemotherapy resistance is one of the most common causes of death among patients with ovarian cancer, and identifying novel antitumor agents is a priority.
Lianqiao Qiao, Xiaomei Wu, Jing Zhang, Lei Liu, Xiaoxin Sui, Ru Zhang, Wenxue Liu, Fangqian Shen, Yunyan Sun, X. Xi   +9 more
semanticscholar   +1 more source

NLRP6-caspase 4 inflammasome activation in response to cariogenic bacterial lipoteichoic acid in human dental pulp inflammation.

International Endodontic Journal, 2020
AIM To explore the presence and function of NLRP6-caspase 4 inflammasome in human pulp tissue and human dental pulp cells (HDPCs). METHODOLOGY Pulp tissue was collected from freshly extracted human caries-free third molars or third molars with ...
X. Tian, R. Li, C. Liu, F. Liu, L. Yang, S. P. Wang, C. Wang   +6 more
semanticscholar   +1 more source

Assessment of caspase-4 released free AFC by RP-HPLC and fluorescence detection

Journal of Chromatography B, 2008
A simple RP-HPLC method based on fluorescence detection was developed for the quantitation of 7-amino-4-trifluoro methylcoumarin (AFC) in cell lysates from JEG-3 choriocarcinoma cells for determination of caspase-4 activity. In contrast to the established methods of AFC detection using a fluorescence microplate reader or using a fluorescence photometer,
Sandra, Koehn, Mike, Trueck, Tobias G, Poehlmann, Ekkehard, Schleussner, Udo R, Markert, Lydia, Seyfarth   +5 more
openaire   +2 more sources