Results 31 to 40 of about 12,127,416 (284)

LPS-aggregating proteins GBP1 and GBP2 are each sufficient to enhance caspase-4 activation both in cellulo and in vitro. [PDF]

Proc Natl Acad Sci U S A, 2023
Significance Sensing gram-negative bacterial lipopolysaccharide by human caspase-4 is critical for host defense to intracellular gram-negative bacterial pathogens.
Dickinson MS, Kutsch M, Sistemich L, Hernandez D, Piro AS, Needham D, Lesser CF, Herrmann C, Coers J.   +8 more
europepmc   +2 more sources

Inflammation in Hypervolemic Hemodialysis Patients: The Roles of RelB and Caspase-4. [PDF]

Int J Mol Sci, 2023
Hypervolemia is associated with inflammation in hemodialysis (HD) patients. How hypervolemia triggers inflammation is not entirely known. We initiated a cross-sectional study enrolling 40 hemodialysis patients who were categorized into normovolemic (N; 23) and hypervolemic (H; 17) groups by bioimpedance measurement.
Ulrich C, Canim Z, Herberger E, Girndt M, Fiedler R.   +4 more
europepmc   +4 more sources

Intracellular replication of Pseudomonas aeruginosa in epithelial cells requires suppression of the caspase-4 inflammasome. [PDF]

mSphere, 2023
Pathogenesis of Pseudomonas aeruginosa infections can include bacterial survival inside epithelial cells. Previously, we showed that this involves multiple roles played by the type three secretion system (T3SS), and specifically the effector ExoS.
Kroken AR, Klein KA, Mitchell PS, Nieto V, Jedel EJ, Evans DJ, Fleiszig SMJ.   +6 more
europepmc   +2 more sources

Caspase-4/11 exacerbates disease severity in SARS-CoV-2 infection by promoting inflammation and immunothrombosis. [PDF]

Proc Natl Acad Sci U S A, 2022
Significance We report the discovery of fundamental roles for the noncanonical inflammasome molecule Caspase-4/11 in promoting pathological inflammatory and prothrombotic pathways in severe acute respiratory syndrome coronavirus 2 (SARS–CoV-2) infections.
Eltobgy MM, Zani A, Kenney AD, Estfanous S, Kim E, Badr A, Carafice C, Daily K, Whitham O, Pietrzak M, Webb A, Kawahara J, Eddy AC, Denz P, Lu M, Kc M, Peeples ME, Li J, Zhu J, Que J, Robinson R, Rosas Mejia O, Rayner RE, Hall-Stoodley L, Seveau S, Gavrilin MA, Zhang X, Thomas J, Kohlmeier JE, Suthar MS, Oltz E, Tedeschi A, Robledo-Avila FH, Partida-Sanchez S, Hemann EA, Abdelrazik E, Forero A, Nimjee SM, Boyaka PN, Cormet-Boyaka E, Yount JS, Amer AO.   +41 more
europepmc   +2 more sources

Shiga Toxin/Lipopolysaccharide Activates Caspase-4 and Gasdermin D to Trigger Mitochondrial Reactive Oxygen Species Upstream of the NLRP3 Inflammasome

Cell Reports, 2018
Summary: The non-canonical caspase-4 and canonical NLRP3 inflammasomes are both activated by intracellular lipopolysaccharide (LPS), but the crosstalk between these two pathways remains unclear.
Jaye M. Platnich, Hyunjae Chung, Arthur Lau, Christina F. Sandall, Adom Bondzi-Simpson, Huey-Miin Chen, Takanori Komada, Aaron C. Trotman-Grant, Jeremy R. Brandelli, Justin Chun, Paul L. Beck, Dana J. Philpott, Stephen E. Girardin, May Ho, Roger P. Johnson, Justin A. MacDonald, Glen D. Armstrong, Daniel A. Muruve   +17 more
doaj   +2 more sources

New insights into the noncanonical inflammasome point to caspase-4 as a druggable target. [PDF]

Nat Rev Immunol
Elkayam E, Gervais FG, Wu H, Crackower MA, Lieberman J.   +4 more
europepmc   +2 more sources

Bexarotene-induced cell death in ovarian cancer cells through Caspase-4-gasdermin E mediated pyroptosis. [PDF]

Sci Rep, 2022
Bexarotene selectively activates retinoid X receptor, which is a commonly used anticancer agent for cutaneous T-cell lymphoma. In this study, we aimed to investigate the anticancer effect of bexarotene and its underlying mechanism in ovarian cancer in ...
Kobayashi T, Mitsuhashi A, Hongying P, Shioya M, Kojima K, Nishikimi K, Yahiro K, Shozu M.   +7 more
europepmc   +2 more sources

Pyroptosis in Endothelial Cells and Extracellular Vesicle Release in Atherosclerosis via NF-κB-Caspase-4/5-GSDM-D Pathway. [PDF]

Pharmaceuticals (Basel)
Background: Pyroptosis, an inflammatory cell death, is involved in the progression of atherosclerosis. Pyroptosis in endothelial cells (ECs) and its underlying mechanisms in atherosclerosis are poorly understood.
Shamas S, Rahil RR, Kaushal L, Sharma VK, Wani NA, Qureshi SH, Ahmad SF, Attia SM, Zargar MA, Hamid A, Bhat OM.   +10 more
europepmc   +2 more sources

Evolution-inspired redesign of the LPS receptor caspase-4 into an interleukin-1β converting enzyme. [PDF]

Sci Immunol, 2021
Caspase-4 homologs can naturally evolve or be synthetically engineered to directly link cytosolic LPS detection to IL-1β secretion. Multitasking by caspases Caspases are innate immune enzymes that regulate activation of inflammasomes and cell death ...
Devant P, Cao A, Kagan JC.
europepmc   +2 more sources

Pyroptosis: A Common Feature of Immune Cells of Haemodialysis Patients

Toxins, 2021
NLRP-3 inflammasome activation can result in interleukin-1β (IL-1β) release and inflammatory cell death (pyroptosis). Caspase-1 is able to trigger both processes.
Christof Ulrich, Leonie Kneser, Roman Fiedler, Julia Beckert, Susann Wildgrube, Eric Seibert, Sylvia Fick, Christoph Schäfer, Silke Markau, Bogusz Trojanowicz, Matthias Girndt   +10 more
doaj   +1 more source