Results 41 to 50 of about 12,127,416 (284)
Salmonella enterica Serovar Typhimurium Induces NAIP/NLRC4- and NLRP3/ASC-Independent, Caspase-4-Dependent Inflammasome Activation in Human Intestinal Epithelial Cells. [PDF]
Infect Immun, 2022 Naseer N +7 more
europepmc +2 more sources
Frontiers in Immunology, 2023 IntroductionHuman adenovirus (HAdV) is a common respiratory virus, which can lead to severe pneumonia in children and immunocompromised persons, and canonical inflammasomes are reported to be involved in anti-HAdV defense.
Lexi Li +9 more
doaj +1 more source
Lipopolysaccharide Recognition in the Crossroads of TLR4 and Caspase-4/11 Mediated Inflammatory Pathways. [PDF]
Front Immunol, 2020 The innate immune response to lipopolysaccharide is essential for host defense against Gram-negative bacteria. In response to bacterial infection, the TLR4/MD-2 complex that is expressed on the surface of macrophages, monocytes, dendritic, and epithelial
Zamyatina A, Heine H.
europepmc +2 more sources
Caspase-4 Is Required for Activation of Inflammasomes [PDF]
The Journal of Immunology, 2012 Abstract IL-1β and IL-18 are crucial regulators of inflammation and immunity. Both cytokines are initially expressed as inactive precursors, which require processing by the protease caspase-1 for biological activity. Caspase-1 itself is activated in different innate immune complexes called inflammasomes.
Sollberger, Gabriel +4 more
openaire +3 more sources
Increased expression of caspase 1 during active phase of connective tissue disease [PDF]
PeerJ, 2019 Key factors of pyroptosis play an important role in the inflammatory response to connective tissue disease (CTD). However, information on active and stable stages of CTD is scarce.
Rentian Cai +4 more
doaj +2 more sources
Human GBP1 facilitates the rupture of the Legionella-containing vacuole and inflammasome activation
mBio, 2023 The inflammasome is essential for host defense against intracellular bacterial pathogens, including Legionella pneumophila, the causative agent of the severe pneumonia Legionnaires’ disease. Inflammasomes recruit and activate caspases, which promote IL-1
Antonia R. Bass +5 more
doaj +1 more source
HYPERTENSION, 2022 Supplemental Digital Content is available in the text. Background: Endothelial dysfunction enhances vascular inflammation, which initiates pulmonary arterial hypertension (PAH) pathogenesis, further induces vascular remodeling and right ventricular ...
Yusi Wu +7 more
semanticscholar +1 more source
Cell Reports, 2021 Summary: Zoonotic pathogens, such as COVID-19, reside in animal hosts before jumping species to infect humans. The Carnivora, like mink, carry many zoonoses, yet how diversity in host immune genes across species affect pathogen carriage is poorly ...
Zsofi Digby +13 more
doaj +1 more source
bioRxiv, 2023 Pathogenesis of Pseudomonas aeruginosa infections can include bacterial survival inside epithelial cells. Previously, we showed this involves multiple roles played by the type three-secretion system (T3SS), and specifically the effector ExoS.
A. R. Kroken +6 more
semanticscholar +1 more source
Uterine Endoplasmic Reticulum Stress and Its Unfolded Protein Response May Regulate Caspase 3 Activation in the Pregnant Mouse Uterus [PDF]
, 2013 We have previously proposed that uterine caspase-3 may modulate uterine contractility in a gestationally regulated fashion. The objective of this study was to determine the mechanism by which uterine caspase-3 is activated and consequently controlled in ...
Condon, Jennifer C. +5 more
core +8 more sources