Results 61 to 70 of about 12,127,416 (284)

Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death [PDF]

, 2016
Sensing bacterial products in the cytosol of mammalian cells by NOD-like receptors leads to the activation of caspase-1 inflammasomes, and the production of the pro-inflammatory cytokines interleukin (IL)-18 and IL-1β.
Alix, E, Birrell, M, Holden, D, Jennings, E, Matthews, S, Shao, F, Shenoy, A, Thurston, T   +7 more
core   +1 more source

The Atypical Ubiquitin E2 Conjugase UBE2L3 Is an Indirect Caspase-1 Target and Controls IL-1β Secretion by Inflammasomes

Cell Reports, 2017
Caspase-1 activation by inflammasome signaling scaffolds initiates inflammation and antimicrobial responses. Caspase-1 proteolytically converts newly induced pro-interleukin 1 beta (IL-1β) into its mature form and directs its secretion, triggering ...
Matthew J.G. Eldridge, Julia Sanchez-Garrido, Gil Ferreira Hoben, Philippa J. Goddard, Avinash R. Shenoy   +4 more
doaj   +1 more source

Azithromycin inhibits IL-1 secretion and non-canonical inflammasome activation [PDF]

, 2015
Deregulation of inflammasome activation was recently identified to be involved in the pathogenesis of various inflammatory diseases. Although macrolide antibiotics display well described immunomodulatory properties, presumably involved in their clinical ...
Gualdoni, Guido A., Hennig, Annika, Lingscheid, Tilman, Schmetterer, Klaus G., Steinberger, Peter, Zlabinger, Gerhard J.   +5 more
core   +1 more source

Crude ethyl acetate extract of marine microalga, Chaetoceros calcitrans, induces Apoptosis in MDA-MB-231 breast cancer cells [PDF]

, 2014
Background: Marine brown diatom Chaetoceros calcitrans and green microalga Nannochloropsis oculata are beneficial materials for various applications in the food, nutraceutical, pharmaceutical and cosmeceutical industries.
Goh, Su Hua, Loh, Su Peng, Md. Yusoff, Fatimah, Mohamed Alitheen, Noorjahan Banu, Yap, Swee Keong   +4 more
core   +1 more source

ABCA1 deficiency contributes to podocyte pyroptosis priming via the APE1/IRF1 axis in diabetic kidney disease

Scientific Reports, 2023
Decreased ATP Binding Cassette Transporter A1 (ABCA1) expression and caspase-4-mediated noncanonical inflammasome contribution have been described in podocytes in diabetic kidney disease (DKD).
Marie Ito, Gloria Michelle Ducasa, Judith David Molina, Javier Varona Santos, Shamroop Kumar Mallela, Jin Ju Kim, Mengyuan Ge, Alla Mitrofanova, Alexis Sloan, Sandra Merscher, Imari Mimura, Alessia Fornoni   +11 more
doaj   +1 more source

Brainiac Caspases: Beyond the Wall of Apoptosis [PDF]

, 2019
For the last two decades, caspases, a family of cysteine-aspartic proteases, have evolved from being considered solely as regulators of apoptosis or inflammation to having a wider range of functions.
Alonso Bellido, Isabel María, Burguillos García, Miguel Ángel, Espinosa Oliva, Ana María, García Revilla, Juan   +3 more
core   +1 more source

Human caspase-4 mediates noncanonical inflammasome activation against gram-negative bacterial pathogens [PDF]

Proceedings of the National Academy of Sciences, 2015
Significance The innate immune system provides a first line of defense against invading pathogens. The inflammasome is an innate immune complex that activates inflammatory caspases upon infection, causing cell death and IL-1 cytokine release, which initiate defense against gram-negative bacterial pathogens but also mediate septic shock.
Cierra N, Casson, Janet, Yu, Valeria M, Reyes, Frances O, Taschuk, Anjana, Yadav, Alan M, Copenhaver, Hieu T, Nguyen, Ronald G, Collman, Sunny, Shin   +8 more
openaire   +2 more sources

Activation of the Absent in Melanoma 2 Inflammasome in Peripheral Blood Mononuclear Cells From Idiopathic Pulmonary Fibrosis Patients Leads to the Release of Pro-Fibrotic Mediators

Frontiers in Immunology, 2018
Idiopathic pulmonary fibrosis (IPF) is a chronic fibro-proliferative disease characterized by poor prognosis, with a mean survival of ~2–3 years after definite diagnosis.
Michela Terlizzi, Michela Terlizzi, Antonio Molino, Chiara Colarusso, Chiara Colarusso, Chiara Colarusso, Chantal Donovan, Pasquale Imitazione, Pasquale Somma, Rita P. Aquino, Rita P. Aquino, Philip M. Hansbro, Aldo Pinto, Aldo Pinto, Rosalinda Sorrentino, Rosalinda Sorrentino   +15 more
doaj   +1 more source

Molecular Mechanisms Used by Salmonella to Evade the Immune System [PDF]

, 2017
Human and animal pathogens are able to circumvent, at least temporarily, the sophisticated immune defenses of their hosts. Several serovars of the Gram-negative bacterium Salmonella enterica have been used as models for the study of pathogen-host ...
Bernal Bayard, Joaquín, Ramos Morales, Francisco   +1 more
core   +1 more source

Mice Lacking Functional Fas Death Receptors Are Protected from Kainic Acid-Induced Apoptosis in the Hippocampus [PDF]

, 2016
© 2014, Springer Science+Business Media New York. The Fas receptor (FasR)/Fas ligand (FasL) system plays a significant role in the process of neuronal loss in neurological disorders.
Camins, Antoni, Ettcheto, Miren, Gómez-Sintes, Raquel, Lucas, José Javier   +3 more
core   +1 more source