Results 81 to 90 of about 12,127,416 (284)

Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death. [PDF]

, 2017
Apoptosis is a genetically regulated cell suicide programme mediated by activation of the effector caspases 3, 6 and 7. If apoptotic cells are not scavenged, they progress to a lytic and inflammatory phase called secondary necrosis.
Alnemri, Diana, Alnemri, Emad S., Cingolani, Gino, Fernandes-Alnemri, Teresa, Mayes, Lindsey, Rogers, Corey   +5 more
core   +2 more sources

The Lipopolysaccharide-Sensing Caspase(s)-4/11 Are Activated in Cirrhosis and Are Causally Associated With Progression to Multi-Organ Injury

Frontiers in Cell and Developmental Biology, 2021
Background and AimsThe development of multi-organ injury in cirrhosis is associated with increased intestinal permeability, translocation of gut-derived bacterial products [e.g., lipopolysaccharide (LPS)] into the circulation, and increased non-apoptotic
Ugo Soffientini, Ugo Soffientini, Nigel Beaton, Sukriti Baweja, Emmanuel Weiss, Emmanuel Weiss, Chhagan Bihari, Abeba Habtesion, Vishal Patel, Vishal Patel, Vishal Patel, Valerie Paradis, Archana Sharma, Tu Vinh Luong, Andrew Hall, Aida Nadar, Shiv Sarin, Shilpa Chokshi, Roger Williams, Benedicte Py, Richard Moreau, Richard Moreau, Rajiv Jalan, Gautam Mehta, Gautam Mehta   +24 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Identification and Characterization of Novel Caspase Inhibitors: The Unforeseen Effects of NSAIDs [PDF]

, 2016
Proper regulation of cell death and the inflammatory mechanism leading to cell death is vital for the development and homeostasis of living organisms. Dysregulation of cell death leads to cancer, neurodegenerative disorders, and inflammatory conditions ...
Soti, Subada
core   +2 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Role of Pyroptosis in Respiratory Diseases and its Therapeutic Potential

Journal of Inflammation Research, 2022
Jingjing Liu,1– 3 Guoqing Fan,1– 3 Ningning Tao,4 Tieying Sun1,2 1Department of Respiratory Medicine and Critical Care, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing ...
Liu J, Fan G, Tao N, Sun T
doaj  

EFP1 is an ER stress-induced glycoprotein which interacts with the pro-apoptotic protein Par-4 [PDF]

, 2009
We have isolated the rat ortholog of EFP1 (EF-hand binding protein 1) as a novel interaction partner of the pro-apoptotic protein Par-4 (prostate apoptosis response-4).
Appel, Sarah, Boosen, Meike, Koplin, Ansgar, Maertens, Barbara, Preuss, Ute, Vetterkind, Susanne   +5 more
core   +1 more source

BRAF- and MEK-targeted small molecule inhibitors exert enhanced antimelanoma effects in combination with oncolytic reovirus through ER stress [PDF]

, 2015
Reovirus type 3 (Dearing) (RT3D) infection is selective for cells harboring a mutated/activated RAS pathway. Therefore, in a panel of melanoma cell lines (including RAS mutant, BRAF mutant and RAS/BRAF wild-type), we assessed therapeutic combinations ...
Aadil A Khan, Adel Jebar, Alan Melcher, Bollag, Boyce, Carew, Chandra, Chapman, Comins, da Rocha Dias, David Mansfield, Davies, Dhomen, Eleni Karapanagiotou, Fiona Errington-Mais, Flaherty, Flaherty, Galanis, Gollamudi, Grainne McEntee, Hardev Pandha, Heidorn, Heinemann, Hu, Jiang, Jiang, Joan Kyula, Karapanagiotou, Kelly, Kevin J Harrington, Kyula, Lolkema, Malin Pedersen, Mandarà, Marciniak, Martin McLaughlin, Matt Coffey, McArthur, Michelle Wilkinson, Pandha, Richard Marais, Richard Vile, Roulstone, Sei, Sosman, Strong, Tabas, Tay, Tsaytler, Twigger, Victoria Roulstone, Vidal, Young   +52 more
core   +1 more source

Dynamin-related Irgm proteins modulate LPS-induced caspase-4 activation and septic shock

bioRxiv, 2020
Inflammation associated with gram-negative bacterial infections is often instigated by the bacterial cell wall component lipopolysaccharide (LPS).
Ryan H. Finethy, Jacob Dockterman, Miriam Kutsch, Nichole Orench-Rivera, Graham D Wallace, Anthony S. Piro, Sarah Luoma, A. Haldar, Seungmin Hwang, Jennifer Martinez, M. Kuehn, G. Taylor, J. Coers   +12 more
semanticscholar   +1 more source