Results 111 to 120 of about 11,510,202 (303)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Journal of Pharmacological Sciences, 2014 .: In the present study, we investigated the protective effect of methyl 3,4-dihydroxybenzoate (MDHB) against H2O2-induced apoptosis in RGC-5 cells. The RGC-5 cells were cultured in plates for 24 h, which were then pretreated with dimethyl sulfoxide ...
Xing Zhou +9 more
doaj +1 more source
The mechanism and function of extracellular matrix protein Mindin in the colon cancer progression [PDF]
, 2015 在世界范围内，结直肠癌是临床上常见的恶性肿瘤之一。结肠癌的发病机制也在不断细致、深入的研究。然而结肠癌这种实体肿瘤不像单纯的肠癌细胞系。相反，它是由多种类型的细胞和细胞外基质组成的功能失调的器官。细胞外基质是肿瘤微环境的重要组成部分，包含各种各样的细胞因子和代谢产物，具有向细胞传导各种环境信号的作用。这些信号对于细胞生命过程的方方面面都必不可少，包括增殖、分化和死亡等。然而，细胞外基质蛋白在结肠癌发生发展的演变过程中的作用尚未完全明确。 分泌型的细胞外基质蛋白Mindin作为Mindin-F ...
肖传兴
core
Inflammasomes: Molecular Regulation and Implications for Metabolic and Cognitive Diseases [PDF]
, 2014 Inflammasomes are specialized signaling platforms critical for the regulation of innate immune and inflammatory responses. Various NLR family members (i.e., NLRP1, NLRP3, and IPAF) as well as the PYHIN family member AIM2 can form inflammasome complexes ...
Choi, Alexander J.S., Ryter, Stefan W.
core +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Journal for ImmunoTherapy of Cancer, 2020 Background We have previously shown that 5-fluorouracil (5-FU) selectively kills myeloid-derived suppressor cells (MDSCs) and activates NLRP3 (NOD-leucine rich repeat and pyrin containing protein 3) inflammasome.
Francois Ghiringhelli +12 more
doaj +1 more source
IL-1α cleavage by inflammatory caspases of the noncanonical inflammasome controls the senescence-associated secretory phenotype. [PDF]
, 2019 Interleukin-1 alpha (IL-1α) is a powerful cytokine that modulates immunity, and requires canonical cleavage by calpain for full activity. Mature IL-1α is produced after inflammasome activation and during cell senescence, but the protease cleaving IL-1α ...
Cassidy, Liam D +7 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
The regulation of MLKL function during apoptosis [PDF]
, 2016 细胞凋亡是主动性的细胞死亡过程，半胱氨酸蛋白酶caspase在细胞凋亡中发挥着主要作用，因此细胞凋亡也被称为caspase依赖的细胞死亡过程。与细胞凋亡不同，长期以来细胞坏死都被认为是极端理化因素刺激的结果，是不受调控的被动性细胞死亡过程。然而近些年的研究表明，细胞坏死也是受调控的，在包括机体发育、组织损伤应答和抗病毒免疫的多种生理和病理中发挥着重要作用。RIP3是细胞坏死应答的决定因子，当然还有一些重要的蛋白也参与其中，例如RIP1和MLKL。 细胞凋亡和细胞坏死作为细胞程序性死亡的两种主要途径 ...
江诗浩
core
Insights into assembly of the macromolecular inflammasome complex [PDF]
, 2014 This is the published version. It first appeared at http://www.degruyter.com/view/j/infl.2013.1.issue-1/infl-2014-0009/infl-2014-0009.xml.AbstractDramatic advances in our understanding of the ultrastructure of the inflammasome and the molecular ...
Boyle, Joseph P, Monie, Tom P
core +2 more sources