Results 221 to 230 of about 334,347 (284)

Caspase 8 activation independent of Fas (CD95/APO-1) signaling may mediate killing of B-chronic lymphocytic leukemia cells by cytotoxic drugs or γ radiation [PDF]

, 2001
Dylan T. Jones, K. Ganeshaguru, Andres Virchis, Najeem Folarin, Mark W. Lowdell, Atul Mehta, H. G. Prentice, A. V. Hoffbrand, R. Gitendra Wickremasinghe   +8 more
openalex   +1 more source

Caspase-8, association with Alzheimer\u27s disease and functional analysis of rare variants [PDF]

, 2017
Cruchaga, Carlos, et al.,, Lord, Jenny
core   +1 more source

Structure‐Based Development of Ultra‐Broad‐Spectrum 3C‐Like Protease Inhibitors

Advanced Science, EarlyView.
This study provides an in‐depth analysis of the substrate binding pocket of 3CLpros across all coronavirus species using bioinformatics and structural insights, revealing the critical impact of S2/S4 subsite diversity on the broad‐spectrum activity of approved therapeutics.
Haixia Su, Tianqing Nie, Guofeng Chen, Muya Xiong, Yumin Zhang, Guoqing Wu, Mengyuan You, Hang Xie, Jian He, Yanchao Xiong, Hangchen Hu, Wenfeng Zhao, Minjun Li, Gengfu Xiao, Leike Zhang, Yechun Xu   +15 more
wiley   +1 more source

TREM1 facilitates nonresponse to anti-TNF-α monoclonal antibodies in colitis via boosting ITCH/TAK1/caspase-8 axis-mediated macrophage pyroptosis. [PDF]

J Transl Med
Liu XM, Dai ZZ, Luo SJ, Zhai JY, Xie Y, Chen YW.   +5 more
europepmc   +1 more source

Caspase-8-mediated CYLD Cleavage boosts LPS-induced Endotoxic Shock [PDF]

Jianling Liu, Ming Li, Mingyan Xing, Han Liu, Xiaoxia Wu, Lingxia Wang, Xiaoming Li, Xiaoming Zhao, Yangjing Ou, Yue Zhang, Fang Li, Qun Xie, Yongchang Tan, Yangyang Wang, Yangyang Xie, Hanwen Zhang, Hong Li, Yu Li, Yan Luo, Haibing Zhang, Yan Luo, Yan Luo, Haibing Zhang, Haibing Zhang   +23 more
openalex   +1 more source

LncRNA MEG3 influences the proliferation and apoptosis of psoriasis epidermal cells by targeting miR-21/caspase-8 [PDF]

, 2019
Haiyan Jia, Kai Zhang, Wenjing Lü, Gui-Wen Xu, Jianfen Zhang, Zhanli Tang   +5 more
openalex   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

Macrophage caspase-8 inhibition accelerates necrotic core expansion in atheroma plaque in mice. [PDF]

Front Immunol
Pilot T, Solier S, Jalil A, Magnani C, Vanden Berghe T, Vandenabeele P, Masson D, Solary E, Thomas C.   +8 more
europepmc   +1 more source

A Microbiota‐ and IL‐15‐Dependent Innate‐Like B Cell Progenitor Expressing E4BP4

Advanced Science, EarlyView.
This work identifies CD3.NKp46.CD19.NK1.1. NK‐B cells enriched in PDK1‐deficient yet present in wild‐type bone marrow. IL‐15 (via CD122) and TLR9‐microbiota signaling maintain their E4BP4 expression. These cells demonstrate innate immunity, preferentially differentiate into B cells, and unveil a novel microbiota‐ and IL‐15‐dependent regulatory pathway ...
Junming He, Xinlei Hou, Xiaomei Feng, Yayun Dong, Mengqi Ren, Surong Deng, Xinru Yang, Donglin Chen, Lingna Zhao, Shasha Chen, Meixiang Yang, Zhongjun Dong   +11 more
wiley   +1 more source

Targeting caspase-8: a new strategy for combating hepatocellular carcinoma. [PDF]

Front Immunol
Chen H, Lin Y, Chen J, Luo X, Kan Y, He Y, Zhu R, Jin J, Li D, Wang Y, Han Z.   +10 more
europepmc   +1 more source