Results 241 to 250 of about 6,024,904 (336)

AIP1 Regulates Ocular Angiogenesis Via NLRP12-ASC-Caspase-8 Inflammasome-Mediated Endothelial Pyroptosis. [PDF]

Adv Sci (Weinh)
Li Y, Sun Y, Xie D, Chen H, Zhang Q, Zhang S, Wen F, Ou JS, Zhang M, Su L, Li X, Wen WP, Chi W.   +12 more
europepmc   +1 more source

Caspase-6 is the direct activator of caspase-8 in the cytochrome c-induced apoptosis pathway: absolute requirement for removal of caspase-6 prodomain [PDF]

, 2002
Victoria H. Cowling, Julian Downward
openalex   +1 more source

NLRP3 inflammasome plays a redundant role with caspase 8 to promote IL-1β–mediated osteomyelitis

Proceedings of the National Academy of Sciences of the United States of America, 2016
Prajwal Gurung, A. Burton, T. Kanneganti
semanticscholar   +1 more source

QSOX2‐Mediated Disulfide Bond Modification Enhances Tumor Stemness and Chemoresistance by Activating TSC2/mTOR/c‐Myc Feedback Loop in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
High QSOX2 enhances stemness, drug resistance, and metastasis of ESCC cells. QSOX2‐mediated disulfide bond modification activates mTOR/c‐Myc signaling. CAFs‐secreted IGF‐1 drives mTOR/c‐Myc/QSOX2 positive feedback loop. Combining Ebselen, rapamycin, and cisplatin induces tumor dormancy in mice.
Wo‐Ming Chen, Xiao‐Ping Zhang, Xiao Sun, Hai‐Cheng Liu, Yuan‐Yuan Yan, Xue Wei, Yu Liang, Yue Feng, Zhengjie Chen, Yongxu Jia, Chen Jiang, Qian Yan, Lei Li   +12 more
wiley   +1 more source

Pharmacological targeting of caspase-8/c-FLIP_L heterodimer enhances complex II assembly and elimination of pancreatic cancer cells. [PDF]

Commun Biol
König C, Ivanisenko NV, Ivanisenko VA, Kulms D, Lavrik IN.   +4 more
europepmc   +1 more source

DR5 and caspase-8 are dispensable in ER stress-induced apoptosis

Cell Death and Differentiation, 2017
Jason Glab, M. Doerflinger, Christina Nedeva, Irvin Jose, George W Mbogo, J. Paton, A. Paton, Andrew J Kueh, M. Herold, D. Huang, D. Segal, G. Brumatti, H. Puthalakath   +12 more
semanticscholar   +1 more source

Intestinal Epithelial‐Derived USP13 Alleviates Colonic Inflammation by Suppressing GRP78‐mediated Endoplasmic Reticulum Stress

Advanced Science, EarlyView.
USP13 deficiency in intestinal epithelial cells aggravates DSS‐induced colitis by enhancing ER stress and apoptosis. USP13 interacts with GRP78 and reduces its K63‐linked ubiquitination to alleviate epithelial injury. Restoring USP13 expression or targeting the USP13‐GRP78 axis may represent a promising strategy for treating inflammatory bowel disease ...
Chenchen Qian, Chenghong Hu, Yong Xu, Wentao Xu, Zhe Wang, Wan Gan, Weiyang Tang, Lijiang Huang, Aleksandr V. Samorodov, Yi Wang   +9 more
wiley   +1 more source

Jolkinolide B Inhibits Gastric Cancer Growth by Targeting the PANoptosis Molecular Switch Caspase-8. [PDF]

J Cancer
Ma C, Gao L, Song K, Gu B, Wang B, Pu W, Chen H.   +6 more
europepmc   +1 more source

Caspase-8 mutations cause autoimmunity [PDF]

Genome Biology, 2002
openaire   +2 more sources

Atg2A/B deficiency switches cytoprotective autophagy to non-canonical caspase-8 activation and apoptosis

Cell Death and Differentiation, 2017
Zhenyuan Tang, Yoshinori Takahashi, Chong Chen, Y. Liu, Haiyan He, Nikolaos Tsotakos, Jacob M. Serfass, Melat T. Gebru, Han Chen, Megan M. Young, Hong-Gang Wang   +10 more
semanticscholar   +1 more source