Advanced Healthcare Materials, EarlyView.This research introduces a cold plasma‐based platform for treating breast cancer bone metastases. Using a novel bioprinted 3D tumor‐stroma model, it highlights the selective antitumor effects of plasma‐generated reactive species. The platform aims to advance non‐invasive therapeutic strategies, offering potential clinical applications in controlling ...
Laura M. Bouret +4 more
wiley +1 more source
Stains Induce Apoptosis and Autophagy in Primary and Transformed Mast Cells [PDF]
, 2016 Statin drugs are widely employed in the clinic to reduce serum low density lipoproteins (LDLs) in patients with hypocholesteremia. In addition to their cholesterol-lowering effects through HMG CoA reductase antagonism, isoprenyl lipids necessary for ...
Paez, Patrick A
core +1 more source
Phosphate-induced activation of VEGFR2 leads to caspase-9-mediated apoptosis of hypertrophic chondrocytes. [PDF]
iScience, 2023 Yadav PS +3 more
europepmc +1 more source
Advanced Healthcare Materials, EarlyView.An RBC membrane camouflaged, cell‐penetrating peptides R8‐based drug delivery system is constructed to achieve a synergistic combination of natural compounds triptolide (TP) and celastrol (Cel), inducing tumor cell apoptosis, reducing tumor metastasis invasion and triggering autophagy disorder in breast cancer and liver cancer.
Qian Cheng +6 more
wiley +1 more source
Inducible caspase 9-mediated suicide gene therapy using AAV6 vectors in a murine model of breast cancer. [PDF]
Mol Ther Methods Clin Dev, 2023 Pathak S +3 more
europepmc +1 more source
Polypyrimidine Track-binding Protein Binding Downstream of Caspase-2 Alternative Exon 9 Represses Its Inclusion [PDF]
, 2001 Jocelyn Côté +2 more
openalex +1 more source
Advanced Healthcare Materials, EarlyView.This review highlights recent progress in nanocarriers targeting pattern recognition receptors (PRRs), including Toll‐like and NOD‐like receptors, for enhancing the treatment of bacterial sepsis and related complications. These nanomedicines deliver antibiotics and anti‐inflammatory agents while modulating immune responses.
Eman A. Ismail +3 more
wiley +1 more source
Impact of Nanoparticle Stiffness on Endosomal Escape and Signaling Pathways in Cytosolic Delivery
Advanced Healthcare Materials, EarlyView.Nanoparticle (NP) stiffness affects cellular uptake, but its impact on intracellular distribution remains unclear. This study synthesizes silica nanocapsules with varying stiffness, inspired by viral mechanisms, and applies assays to measure cellular uptake and escape efficiency.
Yali Zhang +6 more
wiley +1 more source
Caspase-9 inhibition triggers Hsp90-based chemotherapy-mediated tumor intrinsic innate sensing and enhances antitumor immunity. [PDF]
J Immunother Cancer, 2023 Li J +10 more
europepmc +1 more source
A Unique Downstream Estrogen Responsive Unit Mediates Estrogen Induction of Proteinase Inhibitor-9, a Cellular Inhibitor of IL-1β- Converting Enzyme (Caspase 1) [PDF]
, 2001 Sacha A. Krieg +2 more
openalex +1 more source