Results 11 to 20 of about 5,120,269 (330)
International Journal of Biochemistry and Cell Biology, 2020 Caspase-9 is a member of caspase family of cysteine proteases that have been implicated in apoptosis and cytokine processing. When cells receive apoptotic stimuli, mitochondria releases cytochrome c which then binds to Apaf-1, the mammalian Ced-4 ...
K. Kuida
semanticscholar +3 more sources
CASPASE 9 GENE EXPRESSION AND CASPASE 9 PROTEIN IN CHRONIC MYELOID LEUKEMIA IN IRAQ
The Iraqi Journal of Agricultural science, 2022 The following study was carried out to investigate gene expressions of the CASPASE 9 gene and CASPASE 9 protein with the development of chronic myeloid leukemia (CML) in Iraq.
Abdullah W. K., Maha F. A.
doaj +2 more sources
Caspase-9: structure, mechanisms and clinical application
Oncotarget, 2017 As the most intensively studied initiator caspase, caspase-9 is a key player in the intrinsic or mitochondrial pathway which is involved in various stimuli, including chemotherapies, stress agents and radiation.
Ping Li +7 more
semanticscholar +4 more sources
Oncogene-dependent apoptosis is mediated by caspase-9 [PDF]
Proceedings of the National Academy of Sciences, 1998 Understanding how oncogenic transformation sensitizes cells to apoptosis may provide a strategy to kill tumor cells selectively. We previously developed a cell-free system that recapitulates oncogene dependent apoptosis as reflected by activation of ...
Fearnhead, H. O. +6 more
core +4 more sources
A Rapamycin-Activated Caspase 9-Based Suicide Gene [PDF]
Molecular Therapy, 2018 Engineered T cell therapies show considerable promise in the treatment of refractory malignancies. Given the ability of engineered T cells to engraft and persist for prolonged periods along with unpredicted toxicities, incorporation of a suicide gene to ...
M. Stavrou +7 more
semanticscholar +4 more sources
Caspase-9 and APAF-1 form an active holoenzyme [PDF]
Genes & Development, 1999 Autocatalytic activation of initiator caspases is the link between pro-apoptotic signals and the destruction machinery of apoptosis. Activation of caspase-9, which mediates oncogene and drug-induced apoptosis, requires binding to the protein APAF-1.
Rodriguez, J., Lazebnik, Y.
core +4 more sources
Caspase-9 swings both ways in the apoptosome [PDF]
Molecular & Cellular Oncology, 2017 For nearly 2 decades, investigators have debated whether cysteinyl-aspartate-specific protease 9 (caspase-9) is activated within the apoptotic protease-activating factor 1 (Apaf-1) apoptosome through proximity-induced homodimerization or through ...
Chu-Chiao Wu, Shawn B. Bratton
doaj +3 more sources
A Complex between Atg7 and Caspase-9 [PDF]
Journal of Biological Chemistry, 2013 Background: Several cross-talk mechanisms between autophagy and apoptosis have been identified, where the same protein plays a central role in the opposing processes. Results: This study identified a novel cross-talk mechanism involving an Atg7·caspase-9
Jie Han +5 more
semanticscholar +2 more sources