Results 11 to 20 of about 301,365 (321)
Engineering a dimeric caspase-9: a re-evaluation of the induced proximity model for caspase activation. [PDF]
PLoS Biology, 2005 Caspases are responsible for the execution of programmed cell death (apoptosis) and must undergo proteolytic activation, in response to apoptotic stimuli, to function.
Yang Chao +5 more
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A non-apoptotic role for caspase-9 in muscle differentiation [PDF]
Journal of Cell Science, 2008 Caspases, a family of cysteine proteases most often investigated for their roles in apoptosis, have also been demonstrated to have functions that are vital for the efficient execution of cell differentiation. One such role that has been described is the requirement of caspase-3 for the differentiation of skeletal myoblasts into myotubes but, as yet ...
Murray, Thomas VA +7 more
openaire +7 more sources
An inducible caspase 9 safety switch for T-cell therapy [PDF]
Blood, 2005 Abstract The efficacy of adoptive T-cell therapy as treatment for malignancies may be enhanced by genetic modification of infused cells. However, oncogenic events due to vector/transgene integration, and toxicities due to the infused cells themselves, have tempered enthusiasm. A safe and efficient means of removing aberrant cells in vivo
Straathof, KC +8 more
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cDNA cloning and promoter analysis of rat caspase-9 [PDF]
Biochemical Journal, 2001 Caspase-9 is the apex caspase of the mitochondrial pathway of apoptosis, which plays a critical role in apoptotic initiation and progression. However, gene regulation of caspase-9 is largely unknown. This is in part due to the lack of information on the gene promoter.
Junichiro Nishiyama +3 more
openalex +4 more sources
Caspase-9 suppresses metastatic behavior of MDA-MB-231 cells in an adaptive organoid model [PDF]
Scientific ReportsCaspase-9, a cysteine-aspartate protease traditionally associated with intrinsic apoptosis, has recently emerged as having non-apoptotic roles, including influencing cell migration—an aspect that has received limited attention in existing studies. In our
Farzaneh Falahi +3 more
doaj +2 more sources
Correction: Neurovascular injury associated non-apoptotic endothelial caspase-9 and astroglial caspase-9 mediate inflammation and contrast sensitivity decline [PDF]
Cell Death and Disease, 2022 Crystal Colón Ortiz +6 more
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Indian Journal of Animal Sciences, 2022 The present study was conducted to evaluate the expression of caspase-3, caspase-9, growth differentiation factor-9 (GDF-9) and insulin growth factor-1 (IGF-1) genes in oocytes cultured in vitro with optimum and elevated doses of amphiregulin (50 ng and
RAMESH HONDARAVALLI SOMASHETTY +2 more
doaj +1 more source
Diagnostics, 2021 Ovarian cancer remains a major diagnostic and therapeutic problem in modern gynecological oncology. For this reason, research which focuses on the search for new diagnostic markers and the assessment of their possible usefulness in clinical practice is ...
Aleksandra Mielczarek-Palacz +2 more
doaj +1 more source
Proteolytic Processing of the Caspase-9 Zymogen Is Required for Apoptosome-mediated Activation of Caspase-9 [PDF]
Journal of Biological Chemistry, 2013 Maturation of the single-chain caspase-9 zymogen through autoproteolytic processing is mediated by the Apaf-1 apoptosome at the onset of apoptosis. Processed caspase-9 and the apoptosome form a holoenzyme with robust proteolytic activity that is 2-3 orders of magnitude higher than that of free processed caspase-9.
Di Wu +4 more
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The Apoptosome Activates Caspase-9 by Dimerization [PDF]
Molecular Cell, 2006 The apical protease of the human intrinsic apoptotic pathway, caspase-9, is activated in a polymeric activation platform known as the apoptosome. The mechanism has been debated, and two contrasting hypotheses have been suggested. One of these postulates an allosteric activation of monomeric caspase-9; the other postulates a dimer-driven assembly at the
Cristina Pop +3 more
openaire +3 more sources