Results 231 to 240 of about 746,982 (336)

Emodin Alleviates Sepsis‐Induced Multiorgan Damage by Inhibiting NETosis through Targeting Neutrophils BCL‐10

Advanced Science, EarlyView.
Emodin targets BCL‐10 to modulate the BCL‐10/MALT1 complex, thereby suppressing NF‐κB activation and significantly exerting multiorgan protective effects in sepsis. Abstract Sepsis is a life‐threatening condition caused by dysregulated host responses to infection, characterized by excessive inflammation and abnormal coagulation.
Xiaolong Xu, Yumeng Yan, Meiling Zheng, Mina Zhang, Tengfei Chen, Zhicheng Qu, Yinglu Bai, Shuwen Zhang, Chunming Zhao, Yifan Shi, Yan Lin, Ning Wang, Yunjing Bai, Yating Zhai, Zhaofang Bai, Wei Guo, Qingquan Liu   +16 more
wiley   +1 more source

Caspase-14-like Proteases: An Epidermal Caspase and Its Evolutionarily Ancient Relatives. [PDF]

Biomolecules
Eckhart L, Sachslehner AP, Steinbinder J, Fischer H.   +3 more
europepmc   +1 more source

IL-12–induced IFN-γ is dependent on caspase-1 processing of the IL-18 precursor

, 1999
Giamila Fantuzzi, David Reed, Charles A. Dinarello   +2 more
openalex   +1 more source

Discovery of Natural Compound α‐Hederin via Large‐Scale Screening as a Targeted JAK/STAT3 Inhibitor for Ovarian Cancer Therapy

Advanced Science, EarlyView.
This study identifies α‐Hederin as a potent dual JAK1/JAK2 inhibitor that blocks STAT3 activation in ovarian cancer. By disrupting STAT3‐driven transcriptional programs, α‐Hederin suppresses tumor proliferation, invasion, and EMT, while enhancing cisplatin efficacy and overcoming chemoresistance.
Jiayu Wang, Pengzhan He, Cheng Liu, Xin Chen, Yilin Tan, Rui Qu, Yan Zhang, Zhou Li, Tailang Yin, Zhinang Yin   +9 more
wiley   +1 more source

Comparison of necrotizing enterocolitis (NEC)-related apoptosis factors between preterm and full-term rats. [PDF]

Sci Rep
Lee HR, Ko D, Lee KY, Kim SY, Youn JK, Yang HB, Kim HY.   +6 more
europepmc   +1 more source

The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis

Nature Immunology, 2009
L. Franchi, T. Eigenbrod, Raúl Muñoz-Planillo, G. Núñez   +3 more
semanticscholar   +1 more source

Fas-Mediated Suicide of Tumor-Reactive T Cells Following Activation by Specific Tumor: Selective Rescue by Caspase Inhibition [PDF]

, 1999
Tal Zaks, Dale B. Chappell, Steven A. Rosenberg, Nicholas P. Restifo   +3 more
openalex   +1 more source

Irisin Attenuates Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension via Ubiquitin‐Mediated Regulation of ENO1

Advanced Science, EarlyView.
Irisin is a crucial plasma biomarker and promising therapeutic target that reflects disease severity, pulmonary vascular remodeling status and clinical outcome in patients with pulmonary arterial hypertension (PAH). As a novel protective factor, irisin is downregulated in PAH. By ubiquitination, irisin promotes Enolase 1 degradation and suppresses cell
Na Sun, Yong‐Bing Wang, Jing Huang, Run‐Wei Deng, Hui‐Yu He, Lei Gao, Xuan Gao, You‐Li Fan, Yan Cong, Yao‐Lei Guo, Yi‐Qiang Chen, Gui‐Jia Wang, Shao‐Hong Fang, Xia Gu, Bo Yu, Bing‐Xiang Wu   +15 more
wiley   +1 more source

The role of stem cell-derived exosomes in regulating pyroptosis for disease therapy. [PDF]

Stem Cell Res Ther
Guo Y, Liu Q, Yang J, Gao Y, Liu Y.
europepmc   +1 more source

The IL-1β-Converting Enzyme (Caspase-1) Inhibits Apoptosis of Inflammatory Neutrophils Through Activation of IL-1β [PDF]

, 1998
R. William, G. Watson, Ori D. Rotstein, Jean Parodo, Richard Bitar, John C. Marshall   +5 more
openalex   +1 more source