Results 241 to 250 of about 333,383 (311)

SLC26A4 regulates autophagy and activates the NLRP3 inflammasome to mediate pathological cardiac hypertrophy. [PDF]

Sci Rep
Tang LQ, Wang LL, Tang QF, Wang W.
europepmc   +1 more source

MEK Kinase 1, a Substrate for DEVD-Directed Caspases, Is Involved in Genotoxin-Induced Apoptosis

, 1998
Christian Widmann, Pär Gerwins, Nancy L. Johnson, Matthew Jarpe, Gary L. Johnson   +4 more
openalex   +1 more source

Mechanistic Studies on the Role of IL-17/NLRP3 in Arsenic-Induced Activation of Hepatic Stellate Cells Through Hepatocyte Proptosis. [PDF]

Toxics
Hu T, Chen M, Tian S, Luo P, Zhang J.
europepmc   +1 more source

Microglial ApoD‐induced NLRC4 inflammasome activation promotes Alzheimer's disease progression

Animal Models and Experimental Medicine, EarlyView.
We found that NLRC4 inflammasome was activated in microglia releasing IL6 and TNF‐α to impair the hippocampal neural stem cells (NSCs) self‐proliferation. ApoD contributed to activating NLRC4 inflammasome in microglia. Targeting the ApoD provides beneficial effects on NSCs self‐proliferation and mature neurons survival.
Yaliang Yu, Jianzhou Lv, Dan Ma, Ya Han, Yaheng Zhang, Shanlong Wang, Zhitao Wang   +6 more
wiley   +1 more source

Pyroptosis in Kawasaki disease: from mechanisms to targeted interventions. [PDF]

Front Immunol
Han XY, Qi HR.
europepmc   +1 more source

Deficiency of DEK proto‐oncogene alleviates allergic rhinitis by inhibiting RhoA/Ezrin‐mediated mitochondrial fission

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the mechanism of DEK regulating RhoA activation Ezrin. Upon house dust mite (HDM) stimulation, HDM‐specific immunoglobulin E (IgE) and inflammatory factors such as interleukin 4 (IL‐4), IL‐5, IL‐13, and eosinophils increased in the nasal mucosa.
Longzhu Dai, Yongde Jin, Jingmei Chai, Jianing Yang, Jiangang Wang, Mu Chen, Liangchang Li, Chongyang Wang, Guanghai Yan   +8 more
wiley   +1 more source

<i>Lycium barbarum</i> Polysaccharides Alleviate Ethanol-Induced Liver Injury by Activating PPAR-α and Inhibiting NLRP-3/Caspase-1-Mediated Pyroptosis. [PDF]

Food Sci Nutr
Cai LB, Zhou Q, Tao N, Chen WZ.
europepmc   +1 more source

Targeting signaling pathways in neurodegenerative diseases: Quercetin's cellular and molecular mechanisms for neuroprotection

Animal Models and Experimental Medicine, EarlyView.
Quercetin regulates signaling pathways in neurodegenerative diseases, including NF‐κB, sirtuins, and PI3K/Akt. Studies show quercetin improves symptoms and pathology in neurodegenerative models. The study aims to incorporate laboratory research into practical medical treatment, focusing on quercetin's neuroprotective effects and optimal dosage ...
Md. Rezaul Islam, Md. Ibrahim Khalil Al‐Imran, Mehrukh Zehravi, Sherouk Hussein Sweilam, Mohammad Rakib Mortuza, Jeetendra Kumar Gupta, Thukani Sathanantham Shanmugarajan, Kadirvel Devi, Tanuja Tummala, Mohammed Ali Alshehri, Kalirajan Rajagopal, Mohammed Asiri, Irfan Ahmad, Talha Bin Emran   +13 more
wiley   +1 more source

Reducing PKCδ inhibits tumor growth through growth hormone by inhibiting PKA/CREB/ERK signaling pathway in pituitary adenoma. [PDF]

Sci Rep
Chen X, Mao J, Zhou L, Jiang W, Li Z, Li Y, Chen S, Tan G, Xie Y, Wang C, Sun J.   +10 more
europepmc   +1 more source

Establishment of rat model for aspiration pneumonia and potential mechanisms

Animal Models and Experimental Medicine, EarlyView.
Aspiration pneumonia was induced in Sprague Dawley rats by intratracheal instillation of hydrochloric acid (HCl, 1.5 μL/g.wt, pH = 1) followed by lipopolysaccharide (LPS, 20 μg/g.wt) after 1 h. The model reproduced hallmark features of acute lung injury, including histological lung damage, microvascular dysfunction, inflammation, hypoxemia, and ...
Hanbing Hu, Junfeng Chen, Yiru Shao, Yuedong Tang, Yu Dun, Obulkasim Memet, Xuanrong Bao, Jie Shen   +7 more
wiley   +1 more source