Results 241 to 250 of about 572,919 (300)

Multi‐Organelle Stress‐Induced Paraptosis by a ROS‐Amplifying Nanocatalyst for Enhanced Cancer Immunotherapy

Advanced Science, EarlyView.
The engineered TF‐Fe@LC nanoplatform programs paraptotic death via multipath ROS amplification that disrupts redox homeostasis, provoking mitochondrial dysfunction, autophagic blockade, and ER stress. This caspase‐independent process elicits robust immunogenic cell death, combining with αPD‐L1 to activate systemic CD8+ T‐cell immunity and suppress ...
Zhe Yu, Haozhe Ren, Hua Li, Jinghan Zhao, Miaomiao Cao, Tian Tang, Youbei Qiao, Liting Chen, Tiehong Yang, Hong Wu   +9 more
wiley   +1 more source

Caspase-3 cleaves and activates the NADase SARM1 to promote apoptosis, linking two cell death mechanisms. [PDF]

Proc Natl Acad Sci U S A
Shi J, Kim YE, DeRuiter NJ, Kadav P, Tessier-Lavigne M.   +4 more
europepmc   +1 more source

Potential gonadal-beneficial effect of sitagliptin against paclitaxel-induced testicular dysfunction via mediating PERK/CHOP/NLRP3/Sestrin2 signaling pathway. [PDF]

Sci Rep
El-Beheiry KM, El-Shitany NA, El-Sayad ME, Elsisi AE.   +3 more
europepmc   +1 more source

Mechanism of GSDMD in the Pathogenesis of <i>Pasteurella multocida</i> PmCQ2. [PDF]

Transbound Emerg Dis
Yang Q, Wang W, Shen X, Lu Y, Zheng J, Ran J, Cao X, Fang R.   +7 more
europepmc   +1 more source

NLRP3/Caspase-1 Regulate Macrophage Efferocytosis by Modulating ADAM17-Mediated MerTK Cleavage in Liver Ischemia-Reperfusion Injury. [PDF]

Research (Wash D C)
Guan G, Yu C, Miao L, Xiong T, Sun Y, Jin X, Zhao P, Lu Y, Wang L, Chen P, Di G.   +10 more
europepmc   +1 more source

PANoptosis as a Potential Therapeutic Target in Drug-Induced Liver Injury: A Narrative Review. [PDF]

J Inflamm Res
Zhang X, Zhou Z, Xie Z, Chen J, Deng Y, Fang Y, Deng J, Ye X.   +7 more
europepmc   +1 more source

The inflammasome next door: characterizing pyroptosis induction in HCV-infected and uninfected bystander cells <i>in vitro</i>. [PDF]

Front Cell Infect Microbiol
Wallace HL, Gardner CL, Ezeanyaegbu CN, Wight J, Lang AS, Russell RS.   +5 more
europepmc   +1 more source