Results 31 to 40 of about 24,421,742 (361)
Open Life Sciences, 2020 This study investigated the anti-fibrotic effects of reversine and Chinese medicine Xiang–Sha–Liu–Jun–Zi decoction (XSLJZD) on thioacetamide (TAA)-induced hepatic injury.
Mai Zhen-Hao +8 more
doaj +1 more source
AIM2 recognizes cytosolic dsDNA and forms a caspase-1 activating inflammasome with ASC
Nature, 2009 The innate immune system senses nucleic acids by germline-encoded pattern recognition receptors. RNA is sensed by Toll-like receptor members TLR3, TLR7 and TLR8, or by the RNA helicases RIG-I (also known as DDX58) and MDA-5 (IFIH1). Little is known about
V. Hornung +7 more
semanticscholar +1 more source
Role of Caspase-1 in the Pathogenesis of Inflammatory-Associated Chronic Noncommunicable Diseases
Journal of Inflammation Research, 2020 Caspase-1 is the first and extensively studied inflammatory caspase that is activated through inflammasome assembly. Inflammasome is a cytosolic formation of multiprotein complex that aimed to start inflammatory response against infections or cellular ...
M. Molla +5 more
semanticscholar +1 more source
YopM Puts Caspase-1 on Ice [PDF]
Cell Host & Microbe, 2012 Caspase-1-mediated detection of pathogens is a potent arm of the innate immune system. LaRock and Cookson (2012) show that the Yersinia type III secretion effector, YopM, directly inhibits caspase-1.
Edward A. Miao, Ine Jorgensen
openaire +3 more sources
Autophagy May Allow a Cell to Forbear Pyroptosis When Confronted With Cytosol-Invasive Bacteria
Frontiers in Immunology, 2022 Inflammatory caspases detect cytosol-invasive Gram-negative bacteria by monitoring for the presence of LPS in the cytosol. This should provide defense against the cytosol-invasive Burkholderia and Shigella species by lysing the infected cell via ...
Carissa K. Harvest +6 more
doaj +1 more source
Substrate and Inhibitor-induced Dimerization and Cooperativity in Caspase-1 but Not Caspase-3 [PDF]
Journal of Biological Chemistry, 2013 Caspases are intracellular cysteine-class proteases with aspartate specificity that is critical for driving processes as diverse as the innate immune response and apoptosis, exemplified by caspase-1 and caspase-3, respectively. Interestingly, caspase-1 cleaves far fewer cellular substrates than caspase-3 and also shows strong positive cooperativity ...
Datta, Debajyoti +3 more
openaire +4 more sources
Increased expression of caspase 1 during active phase of connective tissue disease [PDF]
PeerJ, 2019 Key factors of pyroptosis play an important role in the inflammatory response to connective tissue disease (CTD). However, information on active and stable stages of CTD is scarce.
Rentian Cai +4 more
doaj +2 more sources
Peroxynitrite/PKR Axis Modulates the NLRP3 Inflammasome of Cardiac Fibroblasts
Frontiers in Immunology, 2020 Sepsis/endotoxemia activates the NLRP3 inflammasome of macrophages leading to the maturation and release of IL-1β, an important mediator of the inflammatory response. Reactive oxygen species have been implicated in NLRP3 inflammasome activation. Further,
Ting Lan +11 more
doaj +1 more source
Obesity Science & Practice, 2023 Mechanisms underlying the negative effects of obesity on the brain are still unknown. Obesity is associated with oxidative stress in the brain and neuroinflammation that promotes neurodegenerative diseases.
Erick Gómez‐Apo +4 more
doaj +1 more source
A Role for Caspase-1 in Heart Failure [PDF]
Circulation Research, 2007 Apoptosis of cardiomyocytes is increased in heart failure and has been implicated in disease progression. The activation of “proapoptotic” caspases represents a key step in cardiomyocyte apoptosis. In contrast, the role of “proinflammatory” caspases (caspases 1, 4, 5, 11, 12) is unclear. Here, we study the cardiac function of caspase-1.
Sabine Merkle +8 more
openaire +3 more sources