Results 11 to 20 of about 331,832 (268)

The therapeutic effect of conditioned medium of human amniotic membrane stem cells on heart failure in rats [PDF]

open access: yesمجله پزشکی دانشگاه علوم پزشکی تبریز, 2023
Background. The conditioned medium of stem cells plays an important role in the treatment of various diseases such as heart damage, but its molecular mechanisms are unknown.
Nahid Aboutaleb   +4 more
doaj   +1 more source

Total extract of Abelmoschus manihot L. alleviates uric acid-induced renal tubular epithelial injury via inhibition of caspase-8/caspase-3/NLRP3/GSDME signaling

open access: yesFrontiers in Pharmacology, 2022
Purpose: The incidence of uric acid (UA)-induced kidney injury is increasing owing to the high incidence of hyperuricemia in recent years. The flower of Abelmoschus manihot (Linneus) Medik is a traditional Chinese medicinal herb widely used in the ...
Zhihui Ding   +14 more
doaj   +1 more source

Kaposi's sarcoma herpesvirus microRNAs target caspase 3 and regulate apoptosis.

open access: yesPLoS Pathogens, 2011
Kaposi's sarcoma herpesvirus (KSHV) encodes a cluster of twelve micro (mi)RNAs, which are abundantly expressed during both latent and lytic infection.
Guillaume Suffert   +13 more
doaj   +1 more source

Aktifitas Caspase 3 sebagai Indikator Apoptosis pada Sel Kanker Ovarium

open access: yesIndonesian Journal of Cancer, 2007
Kematian yang diakibatkan oleh kanker ovarium masih tetap tinggi meskipun sudah dengan penanganan yang agresif. Pemberian kemoterapi merupakan bagian penting selain tindakan operasi di dalam pengobatan kanker ovarium.
Bambang Dwipoyono
doaj   +1 more source

An improved superoxide-generating nanodevice for oxidative stress studies in cultured cells

open access: yesBiotechnology Reports, 2015
The effects of reactive oxygen species on cells have attracted great attention from both physiological and pathological aspects. Superoxide (O2−) is the primary reactive oxygen species formed in animals.
Minoru Tamura   +5 more
doaj   +1 more source

The Role of Caspases in Melanoma Pathogenesis

open access: yesCurrent Issues in Molecular Biology
Melanoma (malignant melanoma, MM) is an aggressive malignant skin cancer with an increasing incidence rate. The complete pathogenesis of MM in not clear.
Agnieszka Szmurło   +7 more
doaj   +1 more source

Blood cytokine patterns suggest a modest inflammation phenotype in subjects with long‐chain fatty acid oxidation disorders

open access: yesPhysiological Reports, 2019
Excessive cellular accumulation or exposure to lipids such as long‐chain acylcarnitines (LCACs), ceramides, and others is implicated in cell stress and inflammation.
Colin S. McCoin   +7 more
doaj   +1 more source

Caspase-3 deficiency during development increases vulnerability to hypoxic–ischemic injury through caspase-3-independent pathways

open access: yesNeurobiology of Disease, 2006
Neonatal hypoxia–ischemia (H–I) is a common cause of perinatal morbidity and mortality leading to prominent activation of caspase-3 in the brain. Previous studies have shown that acute inhibition of caspase-3 can protect against neonatal H–I in rats.
Tim West   +2 more
doaj   +1 more source

Bcl-xL overexpression decreases GILZ levels and inhibits glucocorticoid-induced activation of caspase-8 and caspase-3 in mouse thymocytes

open access: yesJournal of Translational Autoimmunity, 2020
Glucocorticoids promote thymocyte apoptosis and modulate transcription of numerous regulators of thymic apoptosis. Among these, glucocorticoid-induced leucine zipper (GILZ) is strongly upregulated in the thymus.
Isabella Muscari   +8 more
doaj   +1 more source

Caspase 9 and Caspase 3 Immunohistochemical Pattern in Skeletal and Cardiac Muscles at Different Times after Death: An Experimental Study on PMI Estimation

open access: yesDiagnostics, 2021
(1) Background: The estimation of the post mortem interval (PMI) is a challenge for forensic pathologists because data emerging from methods commonly applied are not always conclusive, since several conditions exist that may affect the reliability of ...
Cristina Mondello   +10 more
doaj   +1 more source

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