Results 11 to 20 of about 530,883 (357)

Caspase-3 and caspase-8 expression in breast cancer: caspase-3 is associated with survival [PDF]

Apoptosis, 2016
Impaired apoptosis is one of the hallmarks of cancer. Caspase-3 and -8 are key regulators of the apoptotic response and have been shown to interact with the calpain family, a group of cysteine proteases, during tumorigenesis. The current study sought to investigate the prognostic potential of caspase-3 and -8 in breast cancer, as well as the prognostic
Stewart G. Martin, Yimin Zhang, Yimin Zhang, Emad A. Rakha, Ian O. Ellis, Sarah J. Storr, Andrew R. Green, Xuan Pu   +7 more
openaire   +7 more sources

Metalloporphyrins inactivate caspase‐3 and ‐8 [PDF]

The FASEB Journal, 2005
Activation of caspases represents one of the earliest biochemical indicators for apoptotic cell death. Therefore, measurement of caspase activity is a widely used and generally accepted method to determine apoptosis in a wide range of in vivo and in vitro settings.
Alexandra K. Kiemer, Alexandra K. Kiemer, Birte Brandt, Stefan Seyfried, Hans-Dieter Höltje, Signe B. Blumenthal, Gisa Tiegs, Monika Höltje, Angelika M. Vollmar, Stefan Zahler   +9 more
openaire   +7 more sources

Caspase-3 Colorimetric Assay [PDF]

BioTechniques, 2002
Lizhi Zeng, Larry D. Smith
doaj   +3 more sources

Caspase-3 and Caspase-8 in Patients with Nodular Goiter and Autoimmune Thyroiditis

Galician Medical Journal, 2016
The article presents results of the comparative analysis of peroxidation process activity of caspase-3 and caspase-8 in patients with thyroid adenoma (TA) and nodular goiter with autoimmune thyroiditis (NGAIT).
M. I. Sheremet, V. O. Shidlovskyy, L. P. Sydorchuk, R. I. Sydorchuk   +3 more
doaj   +4 more sources

Uterine Endoplasmic Reticulum Stress and Its Unfolded Protein Response May Regulate Caspase 3 Activation in the Pregnant Mouse Uterus [PDF]

, 2013
We have previously proposed that uterine caspase-3 may modulate uterine contractility in a gestationally regulated fashion. The objective of this study was to determine the mechanism by which uterine caspase-3 is activated and consequently controlled in ...
Condon, Jennifer C., Jeyasuria, Pancharatnam, Kyathanahalli, Chandrashekara, Lydon, John P., Subedi, Kalpana, Suresh, Arvind   +5 more
core   +14 more sources

Apoptosis in the absence of caspase 3 [PDF]

Oncogene, 2001
MCF-7 human breast cancer cells do not express caspase 3, thought by some to be a critical component of the apoptosis cascade. Nonetheless, both mock- and bcl-2-transfected MCF-7 cells undergo apoptosis after treatment with a variety of stimuli, including the DNA-cleaving antimitotic agent, neocarzinostatin (NCS).
Ye Liang, Nina F. Schor, Chaohua Yan
openaire   +3 more sources

Caspase-1, but Not Caspase-3, Promotes Diabetic Nephropathy [PDF]

Journal of the American Society of Nephrology, 2016
Glomerular apoptosis may contribute to diabetic nephropathy (dNP), but the pathophysiologic relevance of this process remains obscure. Here, we administered two partially disjunct polycaspase inhibitors in 8-week-old diabetic (db/db) mice: M-920 (inhibiting caspase-1, -3, -4, -5, -6, -7, and -8) and CIX (inhibiting caspase-3, -6, -7, -8, and -10 ...
Sumra Nazir, Ihsan Gadi, Sanchita Ghosh, Peter P. Nawroth, Shrey Kohli, Moh'd Mohanad Al-Dabet, Khurrum Shahzad, Thati Madhusudhan, Hongjie Wang, Fabian Bock, Satish Ranjan, Berend Isermann   +11 more
openaire   +2 more sources

DECAY, a novel Drosophilacaspase related to mammalian caspase-3 and caspase-7. [PDF]

Journal of Biological Chemistry, 1999
Caspases are key effectors of programmed cell death in metazoans. In Drosophila, four caspases have been described so far. Here we describe the identification and characterization of the fifth Drosophila caspase, DECAY. DECAY shares a high degree of homology with the members of the mammalian caspase-3 subfamily, particularly caspase-3 and caspase-7 ...
Dorstyn, L., Read, S., Quinn, L., Richardson, H., Kumar, S.   +4 more
openaire   +4 more sources

Molecular Dynamics Studies of Caspase-3 [PDF]

Biophysical Journal, 2003
Caspase-3 is a fundamental target for pharmaceutical interventions against a variety of diseases involving disregulated apoptosis. The enzyme is active as a dimer with two symmetry-related active sites, each featuring a Cys-His catalytic dyad and a selectivity loop, which recognizes the characteristic DEVD pattern of the substrate.
Ursula Rothlisberger, Paolo Carloni, Marialore Sulpizi   +2 more
openaire   +3 more sources

Tau and Caspase 3 as Targets for Neuroprotection [PDF]

International Journal of Alzheimer's Disease, 2012
The peptide drug candidate NAP (davunetide) has demonstrated protective effects in variousin vivoandin vitromodels of neurodegeneration. NAP was shown to reduce tau hyperphosphorylation as well as to prevent caspase-3 activation and cytochrome-3 release from mitochondria, both characteristic of apoptotic cell death. Recent studies suggest that caspases
Anat Idan-Feldman, Regina Ostritsky, Illana Gozes   +2 more
openaire   +3 more sources