Apoptosis in the absence of caspase 3 [PDF]
Oncogene, 2001 MCF-7 human breast cancer cells do not express caspase 3, thought by some to be a critical component of the apoptosis cascade. Nonetheless, both mock- and bcl-2-transfected MCF-7 cells undergo apoptosis after treatment with a variety of stimuli, including the DNA-cleaving antimitotic agent, neocarzinostatin (NCS).
Ye Liang, Nina F. Schor, Chaohua Yan
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Roles of apoptosis and autophagy in natural rabies infections
Veterinární Medicína, 2022 The aim of this study was to investigate the activity of apoptosis and autophagy in animals (cows, horses, donkeys, dogs and cats) naturally infected with rabies by using immunohistochemistry, immunofluorescence, and qPCR.
M Ozkaraca +3 more
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Molecular Imaging of Apoptosis: The Case of Caspase-3 Radiotracers
International Journal of Molecular Sciences, 2021 The molecular imaging of apoptosis remains an important method for the diagnosis and monitoring of the progression of certain diseases and the evaluation of the efficacy of anticancer apoptosis-inducing therapies.
Lucas Beroske +4 more
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Histological study of gonads tissues adult stage Artemia salina (Linnaeus 1758) and immunohistochemistry by caspase 3 and HSP70 to detect specific apoptosis markers on gonads tissue after exposure to TBTCl [PDF]
Open Veterinary Journal, 2021 Background: Several types of research have been recently performed on the biological effects of TBTs, including investigations of genitals in invertebrates in response to exposure to TBTs in marine water.
Najla Mohamed Abushaala +2 more
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DECAY, a novel Drosophilacaspase related to mammalian caspase-3 and caspase-7. [PDF]
Journal of Biological Chemistry, 1999 Caspases are key effectors of programmed cell death in metazoans. In Drosophila, four caspases have been described so far. Here we describe the identification and characterization of the fifth Drosophila caspase, DECAY. DECAY shares a high degree of homology with the members of the mammalian caspase-3 subfamily, particularly caspase-3 and caspase-7 ...
Dorstyn, L. +4 more
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The calpain, caspase 12, caspase 3 cascade leading to apoptosis is altered in F508del-CFTR expressing cells. [PDF]
PLoS ONE, 2009 In cystic fibrosis (CF), the most frequent mutant variant of the cystic fibrosis transmembrane conductance regulator (CFTR), F508del-CFTR protein, is misfolded and retained in the endoplasmic reticulum (ER). We previously showed that the unfolded protein
Mathieu Kerbiriou +4 more
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Attenuation of tacrolimus induced oxidative stress, mitochondrial damage, and cell cycle arrest by Boerhavia diffusa root fraction in mdck cell lines [PDF]
Iranian Journal of Basic Medical Sciences, 2021 Objective(s): The protective effect of ethyl acetate fraction (EAF) of Boerhavia diffusa roots against Tacrolimus (TAC) induced nephrotoxicity was studied using MDCK cell lines.Materials and Methods: Ethanolic root extract of B.
Kalaivani M.K. +4 more
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The caspase-3/GSDME signal pathway as a switch between apoptosis and pyroptosis in cancer
Cell Death Discovery, 2020 Apoptosis has long been recognized as a mechanism that kills the cancer cells by cytotoxic drugs. In recent years, studies have proved that pyroptosis can also shrink tumors and inhibit cells proliferation.
Mingxia Jiang +3 more
semanticscholar +1 more source
Molecular Dynamics Studies of Caspase-3 [PDF]
Biophysical Journal, 2003 Caspase-3 is a fundamental target for pharmaceutical interventions against a variety of diseases involving disregulated apoptosis. The enzyme is active as a dimer with two symmetry-related active sites, each featuring a Cys-His catalytic dyad and a selectivity loop, which recognizes the characteristic DEVD pattern of the substrate.
Sulpizi, M. +2 more
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Involvement of Caspase-3 Pathway in Anti-cancer Properties of Genistein in AGS Gastric Cancer Cell Line is Still Enigmatic [PDF]
Avicenna Journal of Medical Biochemistry, 2022 Background: Genistein is an isoflavone that has been reported to have various anti-cancer properties. Objectives: This study aimed to reveal whether or not the anti-cancer properties of genistein in AGS gastric cancer cell line were mediated through ...
Neda Ghasemkhani +4 more
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