Results 241 to 250 of about 6,015,666 (337)

Atg2A/B deficiency switches cytoprotective autophagy to non-canonical caspase-8 activation and apoptosis

Cell Death and Differentiation, 2017
Zhenyuan Tang, Yoshinori Takahashi, Chong Chen, Y. Liu, Haiyan He, Nikolaos Tsotakos, Jacob M. Serfass, Melat T. Gebru, Han Chen, Megan M. Young, Hong-Gang Wang   +10 more
semanticscholar   +1 more source

Peptide‐Based Biomaterials as a Promising Tool for Cancer Radiotherapy

Advanced Science, EarlyView.
This review provides a systematic overview of peptide‐based biomaterials in tumor radiotherapy, covering their roles as both radiosensitizers and radiopharmaceuticals. Peptide‐based radiosensitizers are generally divided into three categories: peptides as direct radiosensitizers, peptides as carriers of radiosensitizers, and targeted‐peptide‐modified ...
Qian Wang, Xinhui Chu, Jianfeng Liu
wiley   +1 more source

Jolkinolide B Inhibits Gastric Cancer Growth by Targeting the PANoptosis Molecular Switch Caspase-8. [PDF]

J Cancer
Ma C, Gao L, Song K, Gu B, Wang B, Pu W, Chen H.   +6 more
europepmc   +1 more source

CARD-8 Protein, a New CARD Family Member That Regulates Caspase-1 Activation and Apoptosis [PDF]

, 2002
Marjaneh Razmara, Srinivasa M. Srinivasula, Lin Wang, Jean‐Luc Poyet, Brad J. Geddes, Peter S. DiStefano, John Bertin, Emad S. Alnemri   +7 more
openalex   +1 more source

NLRP3 inflammasome plays a redundant role with caspase 8 to promote IL-1β–mediated osteomyelitis

Proceedings of the National Academy of Sciences of the United States of America, 2016
Prajwal Gurung, A. Burton, T. Kanneganti
semanticscholar   +1 more source

Novel ATR/PARP1 Dual Inhibitors Demonstrate Synergistic Antitumor Efficacy in Triple‐Negative Breast Cancer Models

Advanced Science, EarlyView.
Novel ATR/PARP1 dual inhibitors are developed for the first time. Advanced lead B8 effectively reduces cell viability in vitro and suppresses tumor growth in vivo, with better potency than ATRi and PARPi alone or in combination. Mechanistically, B8 induces apoptosis, arrests the cell cycle, and inhibits cancer cells colony formation, migration, and ...
Yuan Gao, Jiawei Zhou, Chen‐Chen Wang, Zong‐Hao Wang, Nian‐Dong Mao, Meng‐Lan He, Peng‐Peng Zhang, Ping Huang, Guo‐Wei Ye, Yu‐Qing Zhang, Feng‐Hui Tang, Hang Zhang, Tian Xie, Xiang‐Yang Ye   +13 more
wiley   +1 more source

Helicobacter Pylori-induced BRD2 m⁶A modification sensitizes gastric cancer cells to chemotherapy by breaking FLIP/Caspase-8 homeostasis. [PDF]

Int J Biol Sci
Wang S, Xuan Z, Chen Z, Xu P, Fang L, Li Z, Zhang Y, Liu H, Wang L, Zhang D, Xu H, Yang L, Xu Z.   +12 more
europepmc   +1 more source

Mitomycin C induces apoptosis and caspase-8 and -9 processing through a caspase-3 and Fas-independent pathway [PDF]

, 2002
Farzaneh Pirnia, E Schneider, Daniel Betticher, Markus Borner   +3 more
openalex   +1 more source

NLRP3 regulates a non-canonical platform for caspase-8 activation during epithelial cell apoptosis

Cell Death and Differentiation, 2016
Hyunjae Chung, Akosua Vilaysane, A. Lau, M. Stahl, V. Morampudi, A. Bondzi-Simpson, Jaye M. Platnich, Nathan A. Bracey, Maureen French, P. Beck, J. Chun, B. Vallance, D. Muruve   +12 more
semanticscholar   +1 more source

Dopamine D1 Receptor Contributes to Glucocorticoid‐Associated Osteonecrosis of Femoral Head Protection Through the ATF3/CHOP Axis to Inhibit Osteoblastic Apoptosis

Advanced Science, EarlyView.
This work identifies a novel mechanism by which dopamine D1 receptor (DRD1) contributes to the pathogenesis of glucocorticoid (GC)‐associated osteonecrosis of the femoral head (ONFH) through the regulation of osteoblastic apoptosis, indicating that DRD1 serves as a critical mediator of the crosstalk between the nervous and skeletal systems.
Kai Zheng, Wenming Li, Tianhao Wang, Gaoran Ge, Wei Zhang, Yi Qin, Wenhao Li, Zebin Wu, Zhen Wang, Gang Rui, Yaozeng Xu, Dechun Geng   +11 more
wiley   +1 more source