Results 1 to 10 of about 170,565 (294)
Brainiac Caspases: Beyond the Wall of Apoptosis [PDF]
Frontiers in Cellular Neuroscience, 2019 For the last two decades, caspases, a family of cysteine-aspartic proteases, have evolved from being considered solely as regulators of apoptosis or inflammation to having a wider range of functions.
Ana María Espinosa-Oliva +3 more
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Non-Canonical Roles of Apoptotic Caspases in the Nervous System
Frontiers in Cell and Developmental Biology, 2022 Caspases are a family of cysteine proteases that predominantly cleave their substrates after aspartic acid residues. Much of what we know of caspases emerged from investigation a highly conserved form of programmed cell death called apoptosis.
Mahshid H. Dehkordi +2 more
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eLife, 2023 During apoptosis, caspases degrade 8 out of ~30 nucleoporins to irreversibly demolish the nuclear pore complex. However, for poorly understood reasons, caspases are also activated during cell differentiation.
Ukrae H Cho, Martin W Hetzer
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Frontiers in Veterinary Science, 2021 Caspases, a family of cysteine protease enzymes, are a critical component of apoptotic cell death, but they are also involved in cellular differentiation.
Wonchul Jung +8 more
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BMC Genomics, 2021 Background Apoptosis is an important process for an organism’s innate immune system to respond to pathogens, while also allowing for cell differentiation and other essential life functions.
Susanne Vogeler +3 more
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Identification and functional characterization of two executioner caspases in Crassostrea gigas. [PDF]
PLoS ONE, 2014 Caspase-3 and caspase-7 are two key effector caspases that play important roles in apoptotic pathways that maintain normal tissue and organ development and homeostasis.
Tao Qu +8 more
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Streptococcus pyogenes emm98.1 variants activate inflammatory caspases in human neutrophils
Virulence, 2023 The human pathogen Streptococcus pyogenes (Group A Streptococcus, GAS) is responsible for invasive disease characterized by inflammation and tissue destruction. Inflammatory symptoms of invasive disease may be attributed to the neutrophil response during
Jonathan G. Williams +2 more
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Scutellarein apoptosis mediated by mitochondria in oral squamous cell carcinomas
Biomedical and Biotechnology Research Journal, 2022 Background: The growth of several cancers can be inhibited by naturally occurring medicinal plants. A flavone called Scutellarein found in the perennial herb Scutellaria lateriflora does have a wide range of biological functions. Scutellarein was studied
Markandan Birundadevi +2 more
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The SMAC mimetic AT-101 exhibits anti-tumor and anti-metastasis activity in lung adenocarcinoma cells by the IAPs/ caspase-dependent apoptosis and p65-NFƙB cross-talk [PDF]
Iranian Journal of Basic Medical Sciences, 2021 Objective(s): The Inhibitors of Apoptosis (IAPs) regulate initiator and effector phases of caspase mediated apoptosis. This study evaluates the effects of SMAC mimetic AT-101 in regulation of IAPs/caspases/NFƙB-p65 in an adenocarcinoma cell line ...
Irfan Ahmad +7 more
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Frontiers in Immunology, 2021 IAPs (inhibitors of apoptosis) are endogenous caspase inhibitors with multiple biological activities. In the present study, we show functional characteristics of antiapoptotic protein BIRC2 (cIAP1) in response to Edwardsiella piscicida infection ...
Lu Cao +8 more
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