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Brainiac Caspases: Beyond the Wall of Apoptosis [PDF]
Frontiers in Cellular Neuroscience, 2019 For the last two decades, caspases, a family of cysteine-aspartic proteases, have evolved from being considered solely as regulators of apoptosis or inflammation to having a wider range of functions.
Ana María Espinosa-Oliva +3 more
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Non-Canonical Roles of Apoptotic Caspases in the Nervous System
Frontiers in Cell and Developmental Biology, 2022 Caspases are a family of cysteine proteases that predominantly cleave their substrates after aspartic acid residues. Much of what we know of caspases emerged from investigation a highly conserved form of programmed cell death called apoptosis.
Mahshid H. Dehkordi +2 more
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eLife, 2023 During apoptosis, caspases degrade 8 out of ~30 nucleoporins to irreversibly demolish the nuclear pore complex. However, for poorly understood reasons, caspases are also activated during cell differentiation.
Ukrae H Cho, Martin W Hetzer
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Caspase-2: the orphan caspase [PDF]
Cell Death & Differentiation, 2011 Despite an abundance of literature on the role of caspase-2 in apoptosis, there exists much controversy about this protease making it difficult to place caspase-2 correctly in the apoptotic cascade, and hence its role in apoptosis remains unclear. The identification of the PIDDosome as a signaling platform for caspase-2 activation prompted intense ...
L, Bouchier-Hayes, D R, Green
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Frontiers in Veterinary Science, 2021 Caspases, a family of cysteine protease enzymes, are a critical component of apoptotic cell death, but they are also involved in cellular differentiation.
Wonchul Jung +8 more
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BMC Genomics, 2021 Background Apoptosis is an important process for an organism’s innate immune system to respond to pathogens, while also allowing for cell differentiation and other essential life functions.
Susanne Vogeler +3 more
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Cell Death & Differentiation, 1999 Caspases are the key effector molecules of the physiological death process known as apoptosis, although some are involved in activation of cytokines, rather than cell death. They exist in most of our cells as inactive precursors (zymogens) that kill the cell once activated. Caspases can be controlled in two ways.
P G, Ekert, J, Silke, D L, Vaux
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Identification and functional characterization of two executioner caspases in Crassostrea gigas. [PDF]
PLoS ONE, 2014 Caspase-3 and caspase-7 are two key effector caspases that play important roles in apoptotic pathways that maintain normal tissue and organ development and homeostasis.
Tao Qu +8 more
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Streptococcus pyogenes emm98.1 variants activate inflammatory caspases in human neutrophils
Virulence, 2023 The human pathogen Streptococcus pyogenes (Group A Streptococcus, GAS) is responsible for invasive disease characterized by inflammation and tissue destruction. Inflammatory symptoms of invasive disease may be attributed to the neutrophil response during
Jonathan G. Williams +2 more
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Cell Death & Differentiation, 2006 The relatively common occurrence of sequences within proteins that match the consensus substrate specificity of caspases in intracellular proteins suggests a multitude of substrates in vivo - somewhere in the order of several hundred in humans alone. Indeed, the list of proteins that are reported to be cleaved by caspases in vitro proliferates rapidly.
J C, Timmer, G S, Salvesen
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