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Effector Caspases and Leukemia [PDF]
International Journal of Cell Biology, 2011 Caspases, a family of aspartate-specific cysteine proteases, play a major role in apoptosis and a variety of physiological and pathological processes.
Ying Lu, Guo-Qiang Chen
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Brainiac Caspases: Beyond the Wall of Apoptosis [PDF]
Frontiers in Cellular Neuroscience, 2019 For the last two decades, caspases, a family of cysteine-aspartic proteases, have evolved from being considered solely as regulators of apoptosis or inflammation to having a wider range of functions.
Ana María Espinosa-Oliva +3 more
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Caspases in synaptic plasticity [PDF]
Molecular Brain, 2012 Caspases are a family of cysteine proteases that play key roles in programmed cell death (apoptosis). Mounting evidence in recent years shows that caspases also have important non-apoptotic functions in multiple cellular processes, such as synaptic ...
Li Zheng, Sheng Morgan
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Identification of a new caspase homologue: caspase-14 [PDF]
Cell Death & Differentiation, 1998 Caspases are cysteinyl aspartate-specific proteinases, many of which play a central role in apoptosis. Here, we report the identification of a new murine caspase homologue, viz. caspase-14. It is most related to human/murine caspase-2 and human caspase-9, possesses all the typical amino acid residues of the caspases involved in catalysis, including the
Marc Van de Craen +8 more
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Anti-proliferative and apoptotic potential of Ferula asafoetida’s essential oil on Colon Cancer via inhibiting NF-kB and TNF-alpha receptors pathway [PDF]
Iranian Journal of Colorectal Research, 2023 Purpose: The current investigation was conducted with the aim to elucidate and determine the anti-cancer efficacy in vitro on colon carcinoma human cell lines and to determine its probable mode of action.
Shailja Verma +3 more
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Non-Canonical Roles of Apoptotic Caspases in the Nervous System
Frontiers in Cell and Developmental Biology, 2022 Caspases are a family of cysteine proteases that predominantly cleave their substrates after aspartic acid residues. Much of what we know of caspases emerged from investigation a highly conserved form of programmed cell death called apoptosis.
Mahshid H. Dehkordi +2 more
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eLife, 2023 During apoptosis, caspases degrade 8 out of ~30 nucleoporins to irreversibly demolish the nuclear pore complex. However, for poorly understood reasons, caspases are also activated during cell differentiation.
Ukrae H Cho, Martin W Hetzer
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Caspase-2: the orphan caspase [PDF]
Cell Death & Differentiation, 2011 Despite an abundance of literature on the role of caspase-2 in apoptosis, there exists much controversy about this protease making it difficult to place caspase-2 correctly in the apoptotic cascade, and hence its role in apoptosis remains unclear. The identification of the PIDDosome as a signaling platform for caspase-2 activation prompted intense ...
Lisa Bouchier-Hayes, Douglas R. Green
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Frontiers in Veterinary Science, 2021 Caspases, a family of cysteine protease enzymes, are a critical component of apoptotic cell death, but they are also involved in cellular differentiation.
Wonchul Jung +8 more
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Are metacaspases caspases? [PDF]
The Journal of Cell Biology, 2007 The identification of caspases as major regulators of apoptotic cell death in animals initiated a quest for homologous peptidases in other kingdoms. With the discovery of metacaspases in plants, fungi, and protozoa, this search had apparently reached its goal.
Peter Vandenabeele +5 more
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