Results 151 to 160 of about 170,565 (294)

Multiplexed Luminal Tissue Constructs with Reconfigurable Barriers for Dynamic Modeling of Multi‐Tissue Interactions

Advanced Materials Technologies, EarlyView.
This study describes the fabrication of arrays of luminal tissue constructs for 3D luminal tissue modeling. An oil or media‐filled reservoir between constructs serves as a liquid barrier or bridge to regulate communication between lumens within the array for modeling multi‐tissue interactions in vitro. Abstract Cell‐lined luminal structures are crucial
Mouhita Humayun, José A. Jiménez‐Torres, Chao Li, Jose M. Ayuso, Karina Lugo‐Cintron, Joseph Ulbrich, Benjamin Myers, Sheena C. Kerr, Adeel Ahmed, David J. Beebe   +9 more
wiley   +1 more source

Loss of TDP‐43 function accelerates tauopathy and death of vulnerable neurons by promoting caspase 3‐mediated endoproteolytic cleavage of tau [PDF]

Meghraj Singh Baghel, G Burns, Margarita Tsapatsis, Aswathy Peethambaran Mallika, Shaelyn R Marx, Tong Li, Philip C. Wong   +6 more
openalex   +1 more source

Mitochondria‐Specific Protein Delivery by Protease‐Triggered Release in Plants with Single‐Walled Carbon Nanotubes

Advanced Materials Technologies, EarlyView.
Polymer‐coated carbon nanotubes were engineered as protease‐responsive nanocarriers for protein delivery in intact plants. GFP cargo can be released by cytosolic phytaspase cleavage and subsequently targeted to mitochondria via an N‐terminal sequence, enabling controlled intracellular protein delivery without tissue damage and demonstrating stable ...
Simon Sau Yin Law, Takehiro Suzuki, Tsuyohiko Fujigaya, Keiji Numata   +3 more
wiley   +1 more source

A Patient‐Derived Organoid Biobank of Adamantinomatous Craniopharyngioma as a Platform for Drug Discovery

Advanced Science, EarlyView.
This study successfully establishes adamantinomatous craniopharyngioma (ACP) patient‐derived organoids (PDOs) that preserve the histopathological and genetic features of the original tumors. Through drug sensitivity assays and subsequent mechanistic analyses, the study demonstrates that Ceritinib exerts its inhibitory effects on ACP PDO growth by ...
Huarong Zhang, Chaohu Wang, Jun Fan, Zexin Chen, Haoying Yu, Yawen Bai, Tingcheng Zhang, Qianchao Zhu, Yiwen Feng, Peirong Niu, Jiaqian Chen, Liping Yang, Xueying Li, Lei Yu, Songtao Qi, Yi Liu   +15 more
wiley   +1 more source

Gene Therapy With the Caspase Activation and Recruitment Domain Reduces the Ocular Inflammatory Response [PDF]

, 2015
Cristhian J. Ildefonso, Henrique Jaime, Manas R. Biswal, Sanford L. Boye, Qiuhong Li, William W. Hauswirth, Alfred S. Lewin   +6 more
openalex   +1 more source

EIF1AX Nucleolar Condensates Enhance Susceptibilities for the Management of Endometrial Cancer

Advanced Science, EarlyView.
This schematic illustrates the mechanism of a senolytic strategy in endometrial cancer. EIF1AX facilitates the incorporation of DDX21 into nucleolar condensates, an event that suppresses rDNA transcription and induces cellular senescence. The compound 2,5‐MeC exploits this pathway by promoting EIF1AX nucleolar translocation and condensate formation ...
Chengyu Lv, Zihang Lin, Jiandong Sun, Yuhong Ye, Qibin Wu, Liangzhi Cai, Dabin Liu, Pengming Sun, Shie Wang   +8 more
wiley   +1 more source

Activation of caspase-8 during N -(4-hydroxyphenyl)retinamide-induced apoptosis in fas-defective hepatoma cells [PDF]

, 2001
Kyung-Ran You, Myung-Nym Shin, Raekil Park, Seungok Lee, Dae-Ghon Kim   +4 more
openalex   +1 more source

CCDC41 Drives Oocyte Meiotic Progression by Promoting Rab11a/Rab7‐Positive Vesicle Fusion with Target Membranes

Advanced Science, EarlyView.
CCDC41 is essential for meiotic maturation in mouse oocytes through regulating Rab7‐positive endosomes fusion with lysosomes and Rab11a‐positive vesicle fusion with the plasma membrane. Abstract Coiled‐coil domain‐containing protein 41 (CCDC41), a core component of centriolar distal appendages involved in centriole assembly and ciliary vesicle docking,
Ying Tian, Jiatong Li, Jingyi Kang, Xiangning Xu, Bicheng Wang, Shuo Lou, Jingyu Li, Yuying Yang, Yanbing Zhang, Yangzi Zheng, Jing Weng, Yuanjing Liang, Wei Ma   +12 more
wiley   +1 more source

Effect of caspases and RANKL induced by heavy force in orthodontic root resorption

, 2018
Yukari Minato, Masaru Yamaguchi, Mami Shimizu, Jun Kikuta, Takuji Hikida, Momoko Hikida, Masaaki Suemitsu, Kayo Kuyama, Kazutaka Kasai   +8 more
openalex   +2 more sources

Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor [PDF]

, 2018
Tsan Sam Xiao, Jie Yang, Zhonghua Liu, Chuanping Wang, Rui Yang, Joseph K. Rathkey, Otis Pinkard, Wuxian Shi, Yinghua Chen, George Dubyak, Derek W. Abbott   +10 more
openalex   +1 more source