Results 11 to 20 of about 134,771 (282)

Scutellarein apoptosis mediated by mitochondria in oral squamous cell carcinomas

Biomedical and Biotechnology Research Journal, 2022
Background: The growth of several cancers can be inhibited by naturally occurring medicinal plants. A flavone called Scutellarein found in the perennial herb Scutellaria lateriflora does have a wide range of biological functions. Scutellarein was studied
Markandan Birundadevi, Rangasamy Sivashankar, Sivagnanam Mathukumar   +2 more
doaj   +1 more source

The SMAC mimetic AT-101 exhibits anti-tumor and anti-metastasis activity in lung adenocarcinoma cells by the IAPs/ caspase-dependent apoptosis and p65-NFƙB cross-talk [PDF]

Iranian Journal of Basic Medical Sciences, 2021
Objective(s): The Inhibitors of Apoptosis (IAPs) regulate initiator and effector phases of caspase mediated apoptosis. This study evaluates the effects of SMAC mimetic AT-101 in regulation of IAPs/caspases/NFƙB-p65 in an adenocarcinoma cell line ...
Irfan Ahmad, Safia Irfan, Mirza Masroor Ali Beg, Hosam Kamli, Syed Parveen Ali, Naseem Begum, . Mohammad Alshahrani, Prasanna Rajagopalan   +7 more
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The Zebrafish Antiapoptotic Protein BIRC2 Promotes Edwardsiella piscicida Infection by Inhibiting Caspases and Accumulating p53 in a p53 Transcription-Dependent and -Independent Manner

Frontiers in Immunology, 2021
IAPs (inhibitors of apoptosis) are endogenous caspase inhibitors with multiple biological activities. In the present study, we show functional characteristics of antiapoptotic protein BIRC2 (cIAP1) in response to Edwardsiella piscicida infection ...
Lu Cao, Lu Cao, Dong Yan, Dong Yan, Jun Xiao, Hao Feng, Ming Xian Chang, Ming Xian Chang, Ming Xian Chang   +8 more
doaj   +1 more source

Optimal DL-Methionyl-DL-Methionine Supplementation Improved Intestinal Physical Barrier Function by Changing Antioxidant Capacity, Apoptosis and Tight Junction Proteins in the Intestine of Juvenile Grass Carp (Ctenopharyngodon idella)

Antioxidants, 2022
The present study was a part of a larger research project that aimed to investigate the effects of Met-Met supplementation on fish growth and intestinal health. This study mainly focused on the relationship between dietary Met-Met and intestinal physical
Pei Wu, Yuening Su, Lin Feng, Weidan Jiang, Shengyao Kuang, Ling Tang, Jun Jiang, Yang Liu, Xiaoqiu Zhou   +8 more
doaj   +1 more source

Activation of Pro-apoptotic Caspases in Non-apoptotic Cells During Odontogenesis and Related Osteogenesis

Frontiers in Physiology, 2018
Caspases are well known proteases in the context of inflammation and apoptosis. Recently, novel roles of pro-apoptotic caspases have been reported, including findings related to the development of hard tissues.
Eva Svandova, Eva Svandova, Barbora Vesela, Barbora Vesela, Abigail S. Tucker, Eva Matalova, Eva Matalova   +6 more
doaj   +1 more source

Altered expression of caspases-4 and -5 during inflammatory bowel disease and colorectal cancer : diagnostic and therapeutic potential [PDF]

, 2015
Caspases are a group of proteolytic enzymes involved in the co-ordination of cellular processes, including cellular homeostasis, inflammation and apoptosis.
Caiazza, F, Creagh, EM, Doherty, GA, Fay, J, Flood, B, Heetun, Z, Kay, E, Laukens, Debby, Mills, KHG, O'Grady, A, Oficjalska, K, Ryan, EJ, Sheahan, K   +12 more
core   +2 more sources

Expression of Apoptosis-Related Genes in Cat Testicular Tissue in Relation to Sperm Morphology and Seasonality—A Preliminary Study

Animals, 2021
Apoptosis is a crucial process in spermatogenesis, responsible for the elimination of abnormal sperm cells and testicular regression out of breeding season.
Sylwia Prochowska, Agnieszka Partyka, Wojciech Niżański   +2 more
doaj   +1 more source

Regulation of caspase-3 processing by cIAP2 controls the switch between pro-inflammatory activation and cell death in microglia. [PDF]

, 2014
Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International Licence.
A Castano, AM Verhagen, B Joseph, B Joseph, BP Eckelman, C Du, D Conte, DW Nicholson, E Varfolomeev, H Durkop, H Huang, JE Vince, JL Venero, K Rajalingam, K Saijo, K Saijo, M D'Amelio, M Gyrd-Hansen, M Luo, MA Burguillos, ML Block, N Muller-Sienerth, OH Voss, PL McGeer, S Kamada, SP Burke, ST Beug, T Tenev, V Bocchini, X Cui, Z Han   +30 more
core   +3 more sources

Tumor-promoting function of apoptotic caspases by an amplification loop involving ROS, macrophages and JNK in Drosophila

eLife, 2017
Apoptosis and its molecular mediators, the caspases, have long been regarded as tumor suppressors and one hallmark of cancer is ‘Evading Apoptosis’.
Ernesto Pérez, Jillian L Lindblad, Andreas Bergmann   +2 more
doaj   +1 more source

Combined RhoA morpholino and ChABC treatment protects identified lamprey neurons from retrograde apoptosis after spinal cord injury

Frontiers in Cellular Neuroscience, 2023
Previously, we reported that RhoA knockdown by morpholino antisense oligonucleotides (MOs), and enzymatic digestion of chondroitin sulfate proteoglycans (CSPGs) at the site of injury with chondroitinase ABC (ChABC), each can reduce retrograde neuronal ...
Jianli Hu, Jianli Hu, Guixin Zhang, Guixin Zhang, William Rodemer, Li-Qing Jin, Li-Qing Jin, Michael E. Selzer, Michael E. Selzer, Michael E. Selzer   +9 more
doaj   +1 more source