Legionella pneumophila strain 130b evades macrophage cell death independent of the effector SidF in the absence of flagellin [PDF]
, 2017 International audienceThe human pathogen Legionella pneumophila must evade host cell death signaling to enable replication in lung macrophages and to cause disease. After bacterial growth, however, L.
Abraham, Gilu +10 more
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Caspases: An apoptosis mediator
Journal of Advanced Veterinary and Animal Research, 2015 The process of programmed cell death, or apoptosis, is generally characterized by distinct morphological characteristics and energy - dependent biochemical mechanisms.
Tapan Kumar Palai, Smruti Ranjan Mishra
doaj +1 more source
Reprogramming monocyte-derived macrophages through caspase inhibition
OncoImmunology, 2022 Macrophages are widely distributed innate immune cells that play an indispensable role in a variety of physiologic and pathologic processes, including organ development, host defense, acute and chronic inflammation, solid and hematopoietic cancers ...
Paul Chaintreuil +12 more
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Inflammasomes: caspase-1-activating platforms with critical roles in host defense [PDF]
, 2011 Activation of the inflammatory cysteine protease caspase-1 in inflammasome complexes plays a critical role in the host response to microbial infections.
Lieselotte eVande Walle +3 more
core +2 more sources
Effector Caspase Dcp-1 and IAP Protein Bruce Regulate Starvation-Induced Autophagy during Drosophila Melanogaster Oogenesis [PDF]
, 2008 A complex relationship exists between autophagy and apoptosis, but the regulatory mechanisms underlying their interactions are largely unknown. We conducted a systematic study of Drosophila melanogaster cell death–related genes to determine their ...
Barbosa, Sharon González +4 more
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Plasma Levels of K18 Fragments Do Not Correlate with Alcoholic Liver Fibrosis
Gut and Liver, 2019 Background/Aims Noninvasive markers of liver fibrosis in alcoholic liver disease (ALD) are crucial to establish early intervention. Previous studies have suggested that plasma levels of cleaved keratin-18 (K18; M30) fragments can predict the severity of ...
Viola Schlossberger +6 more
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The endogenous caspase-8 inhibitor c-FLIPL regulates ER morphology and crosstalk with mitochondria [PDF]
, 2014 Components of the death receptors-mediated pathways like caspase-8 have been identified in complexes at intracellular membranes to spatially restrict the processing of local targets.
A Filippini +53 more
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Caspase-independent programmed cell death triggers Ca2PO4 deposition in an in vitro model of nephrocalcinosis [PDF]
, 2018 We provide evidence of caspase-independent cell death triggering the calcification process in GDNF-silenced HK-2 ...
Anglani F. +8 more
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Apoptosis as a factor for organizing autoimmune inflammation in rheumatoid arthritis
Современная ревматология, 2019 The paper summarizes the data available in the literature and those from the authors' studies on the molecular and cellular mechanisms of apoptosis and their state in rheumatoid arthritis (RA).
A. I. Dubikov +2 more
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Peptidyl-Resin Substrates as a Tool in the Analysis of Caspase Activity
Molecules, 2022 Caspases, proteolytic enzymes belonging to the group of cysteine proteases, play a crucial role in apoptosis. Understanding their activity and substrate specificity is extremely important.
Remigiusz Bąchor
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