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mSphere, 2020 The mosquito midgut is a critical barrier that Plasmodium parasites must overcome to complete their developmental cycle and be transmitted to a new vertebrate host.
Nathanie Trisnadi +1 more
doaj +1 more source
Metalloporphyrins inactivate caspase-3 and -8 [PDF]
, 2005 Activation of caspases represents one of the earliest biochemical indicators for apoptotic cell death. Therefore, measurement of caspase activity is a widely used and generally accepted method to determine apoptosis in a wide range of in vivo and in ...
Blumenthal, Signe B. +8 more
core +1 more source
Neuroglobin protects nerve cells from apoptosis by inhibiting the intrinsic pathway of cell death [PDF]
Apoptosis 15:401-411 (2010), 2010 In the past few years, overwhelming evidence has accrued that a high level of expression of the protein neuroglobin protects neurons in vitro, in animal models, and in humans, against cell death associated with hypoxic and amyloid insult. However, until now, the exact mechanism of neuroglobin's protective action has not been determined.
arxiv +1 more source
A cellular stress-directed bistable switch controls the crosstalk between autophagy and apoptosis [PDF]
, 2013 Decision-making between life and death is one of the most important tasks of cells to maintain their genetic integrity. While the surviving mechanism is driven by Beclin1-dependent autophagy, the suicide processes are controlled by caspases-mediated ...
Bánhegyi, Gábor +3 more
core +2 more sources
Inhibitor of apoptosis proteins as E3 ligases for ubiquitin and NEDD8
Biomolecular Concepts, 2013 The inhibitors of apoptosis proteins (IAPs) are endogenous inhibitors for apoptosis. Apoptosis is carried out by caspases, which are the family of cystein proteases. IAPs regulate caspases through two conserved regions, the baculovirus IAP repeats (BIRs)
Kamada Shinji
doaj +1 more source
The Drosophila caspase Ice is important for many apoptotic cell deaths and for spermatid individualization, a nonapoptotic process [PDF]
, 2006 Caspase family proteases play important roles in the regulation of apoptotic cell death. Initiator caspases are activated in response to death stimuli, and they transduce and amplify these signals by cleaving and thereby activating effector caspases.
Baehrecke, Eric H. +8 more
core +2 more sources
Raptor hunted by caspases [PDF]
Cell Death & Disease, 2016 Emergence of survival strategies is a key step for organisms during evolution. The capacity to adapt from nutrient-rich to nutrient-poor environments led to the appearance of protein complexes regulating anabolic and catabolic pathways. The evolutionarily conserved kinase mTOR (mechanistic target of rapamycin) emerged as a crucial and central protein ...
R Martin, M Thome, F Martinon, N Fasel
openaire +5 more sources
Frontiers in Cell and Developmental Biology, 2020 Increasing evidence shows that, in addition to the classical function of protein processing and transport, the Golgi apparatus (GA) is also involved in apoptosis, one of the most common forms of cell death.
Qiang He +7 more
doaj +1 more source
Evolution of virulence: triggering host inflammation allows invading pathogens to exclude competitors. [PDF]
, 2008 Virulence is generally considered to benefit parasites by enhancing resource-transfer from host to pathogen. Here, we offer an alternative framework where virulent immune-provoking behaviours and enhanced immune resistance are joint tactics of invading ...
Alizon S. +9 more
core +2 more sources
Caspase Activation by Anticancer Drugs: The Caspase Storm
Molecular Pharmaceutics, 2007 This study measures the time-dependence of cellular caspase activation by anticancer drugs and compares it with that of cellular respiration. Intracellular caspase activation and cellular respiration were measured during continuous exposure of Jurkat, HL-60, and HL-60/MX2 (deficient in topoisomerase-II) cells to dactinomycin, doxorubicin, and the ...
Tao, Zhimin +3 more
openaire +2 more sources