Results 1 to 10 of about 25,252 (242)

Stimulation of Eryptosis by Caspofungin

Cellular Physiology and Biochemistry, 2016
Background/Aims: The echinocandin antifungal agent caspofungin has been shown to trigger apoptosis of fungal cells. Beyond that, caspofungin is toxic for host mitochondria.
Thomas Peter, Rosi Bissinger, Florian Lang   +2 more
doaj   +1 more source

PIN15 CHRONIC HEPATITIS B (CHB) MANAGEMENT COSTS IN SWEDEN [PDF]

, 2003
L'edifici fou construït l'any 1860, aproximadament.Primer pla, contrapicat d'un edifici d'habitatges entre mitgeres, en cantonada. Consta de planta baixa, cinc plantes pis i terrat.
De Cock, E, Dale, PL, Cerri, KH, Zammit, D, Flamholc, L   +4 more
core   +1 more source

A Mechanosensitive Channel Governs Lipid Flippase-Mediated Echinocandin Resistance in Cryptococcus neoformans

mBio, 2019
Echinocandins show fungicidal activity against common invasive mycoses but are ineffective against cryptococcosis. The underlying mechanism for echinocandin resistance in Cryptococcus neoformans remains poorly understood but has been shown to involve ...
Chengjun Cao, Yina Wang, Seema Husain, Patricia Soteropoulos, Chaoyang Xue   +4 more
doaj   +1 more source

The Aspergillus fumigatus Phosphoproteome Reveals Roles of High-Osmolarity Glycerol Mitogen-Activated Protein Kinases in Promoting Cell Wall Damage and Caspofungin Tolerance

mBio, 2020
The filamentous fungus Aspergillus fumigatus can cause a distinct set of clinical disorders in humans. Invasive aspergillosis (IA) is the most common life-threatening fungal disease of immunocompromised humans. The mitogen-activated protein kinase (MAPK)
Eliciane Cevolani Mattos, Lilian Pereira Silva, Clara Valero, Patrícia Alves de Castro, Thaila Fernanda dos Reis, Liliane F. C. Ribeiro, Mark R. Marten, Rafael Silva-Rocha, Cauã Westmann, Carlos Henrique Tomich de Paula da Silva, Carlton Anthony Taft, Narjes Al-Furaiji, Michael Bromley, Uffe H. Mortensen, J. Philipp Benz, Neil Andrew Brown, Gustavo H. Goldman   +16 more
doaj   +1 more source

Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis [PDF]

, 2018
The quantification of lung fungal burden is critical for the determination of the relative levels of immune protection and fungal virulence in mouse models of pulmonary fungal infection.
Amarsaikhan, Nansalmaa, Sands, Ethan M., Stolz, Dylan J., Templeton, Steven P., Tsoggerel, Angar   +4 more
core   +1 more source

Puupehenone, a Marine-Sponge-Derived Sesquiterpene Quinone, Potentiates the Antifungal Drug Caspofungin by Disrupting Hsp90 Activity and the Cell Wall Integrity Pathway

mSphere, 2020
The cell wall-targeting echinocandin antifungals, although potent and well tolerated, are inadequate in treating fungal infections due to their narrow spectrum of activity and their propensity to induce pathogen resistance.
Siddharth K. Tripathi, Qin Feng, Li Liu, David E. Levin, Kuldeep K. Roy, Robert J. Doerksen, Scott R. Baerson, Xiaomin Shi, Xuewen Pan, Wen-Hui Xu, Xing-Cong Li, Alice M. Clark, Ameeta K. Agarwal   +12 more
doaj   +1 more source

Caspofungin activity against clinical isolates of azole cross-resistant Candida glabrata overexpressing efflux pump genes [PDF]

, 2017
Objectives: Several studies have documented the potent in vitro activity of caspofungin against Candida spp. This is of special concern for Candida glabrata infections that are often resistant to many azole antifungal agents and, consequently, difficult ...
Fadda, Giovanni, Fiori, Barbara, La Sorda, Marilena, Posteraro, Brunella, Sanglard, Dominique, Sanguinetti, Maurizio, Spanu, Teresa   +6 more
core  

Dissection of the Candida albicans class I chitin synthase promoters [PDF]

, 2009
We acknowledge financial support from the Biotechnology and Biological Sciences Research Council (10161), Medical Research Council (New Investigator Award to C.A.M.), the European Community FUNGALWALL and SIGNALPATH initiatives and the Wellcome Trust ...
Gow, Neil A. R., Lenardon, Megan D., Lesiak, Iwona, Munro, Carol A.   +3 more
core   +1 more source

Efficacy of caspofungin dose escalation against Candida albicans and Candida glabrata clinical isolates [PDF]

, 2016
Munkánk során meghatároztuk a caspofungin által kifejtett ölési rátát RPMI-1640-ben, valamint 50% humán szérummal kiegészített tápközegben C. albicans és C. glabrata klinikai izolátumok ellen.
Domán, Marianna
core  

Addition of 17-(allylamino)-17-demethoxy-geldanamycin to a suboptimal caspofungin treatment regimen in neutropenic rats with invasive pulmonary aspergillosis delays the time to death but does not enhance the overall therapeutic efficacy [PDF]

, 2017
Caspofungin (CAS) which is used as salvage therapy in patients with invasive pulmonary aspergillosis (IPA) inhibits the 1,3-β-D-glucan synthesis in Aspergillus fumigatus.
Bakker-Woudenberg, I.A.J.M. (Irma), Eadie, K. (Kimberley), Kate, M.T. (Marian) ten, Refos, J. (Jeanine), Sande, W.W.J. (Wendy) van de, Verbrugh, H.A. (Henri), Vonk, A.G. (Alieke)   +6 more
core   +1 more source