Results 11 to 20 of about 13,325 (156)

Microfluidic live-cell imaging of Aspergillus fumigatus and Candida albicans hyphal growth treated with AmBisome and Caspofungin. [PDF]

J Microsc
Abstract Hyphal forms of human pathogenic fungi cause invasive disease in humans, but the hyphal response to antifungals is understudied. In the major fungal pathogens Aspergillus fumigatus and Candida albicans, we used microfluidic‐coupled, fluorescence‐mediated live‐cell imaging to capture the real‐time responses of fungal hyphae to clinical ...
Thomson DD, Inman R, Nye S, Bignell EM.
europepmc   +2 more sources

Cost-Effectiveness of Once Weekly Rezafungin for the Treatment of Invasive Candidiasis in the United Kingdom. [PDF]

Mycoses
ABSTRACT Background Invasive candidiasis (IC), life‐threatening fungal infections with high economic burden, are often treated first‐line with daily intravenous echinocandins. A new once weekly echinocandin, rezafungin, demonstrated statistically non‐inferior efficacy and numerically shorter intensive care unit (ICU) stay compared to caspofungin in ...
Muszbek N, Angdembe A, Garcia-Vidal C, Bielicka I, Abrams KR, Tolley K, Ruhnke M, Lebmeier M, Hawkins N, Manamley N, Dickerson S.   +10 more
europepmc   +2 more sources

Cost-utility analysis of caspofungin and fluconazole for primary treatment of invasive candidiasis and candidemia in Ethiopia

BMC Health Services Research, 2022
Background Invasive candidiasis and/or candidemia (IC/C) is a common fungal infection leading to significant health and economic losses worldwide. Caspofungin was shown to be more effective than fluconazole in treating inpatients with IC/C. However, cost-
Gebremedhin Beedemariam Gebretekle, Atalay Mulu Fentie, Girma Tekle Gebremariam, Eskinder Eshetu Ali, Daniel Asfaw Erku, Tinsae Alemayehu, Workeabeba Abebe, Beate Sander   +7 more
doaj   +1 more source

Phosphoproteomics of Aspergillus fumigatus Exposed to the Antifungal Drug Caspofungin

mSphere, 2020
Aspergillus fumigatus is an opportunistic and allergenic pathogenic fungus, responsible for fungal infections in humans. A. fumigatus infections are usually treated with polyenes, azoles, or echinocandins.
Eliciane Cevolani Mattos, Giuseppe Palmisano, Gustavo H. Goldman   +2 more
doaj   +1 more source

Candida albicans Strains Adapted to Caspofungin Due to Aneuploidy Become Highly Tolerant under Continued Drug Pressure

Microorganisms, 2022
Candida albicans is a prevalent fungal pathogen of humans. Understanding the development of decreased susceptibility to ECN drugs of this microbe is of substantial interest, as it is viewed as an intermediate step allowing the formation of FKS1 ...
Farha Husain, Anshuman Yadav, Sudisht K. Sah, Jeffrey J. Hayes, Elena Rustchenko   +4 more
doaj   +1 more source

Synergistic Interaction of Caspofungin Combined with Posaconazole against FKS Wild-Type and Mutant Candida auris Planktonic Cells and Biofilms

Antibiotics, 2022
Candida auris is a potential multidrug-resistant pathogen able to cause biofilm-associated outbreaks, where frequently indwelling devices are the source of infections.
Noémi Balla, Fruzsina Kovács, Bence Balázs, Andrew M. Borman, Aliz Bozó, Ágnes Jakab, Zoltán Tóth, Ola Kobaissi, László Majoros, Renátó Kovács   +9 more
doaj   +1 more source

Development of Antifungal Peptides against Cryptococcus neoformans; Leveraging Knowledge about the cdc50Δ Mutant Susceptibility for Lead Compound Development

Microbiology Spectrum, 2022
Cryptococcus neoformans is a major fungal pathogen that often causes life-threatening meningitis in immunocompromised populations. This yeast pathogen is highly resistant to the echinocandin drug caspofungin.
Robert J. Tancer, Yina Wang, Siddhi Pawar, Chaoyang Xue, Gregory R. Wiedman   +4 more
doaj   +1 more source

Evidence supporting a role for mammalian chitinases in efficacy of caspofungin against experimental aspergillosis in immunocompromised rats. [PDF]

PLoS ONE, 2013
Caspofungin, currently used as salvage therapy for invasive pulmonary aspergillosis (IPA), strangely only causes morphological changes in fungal growth in vitro but does not inhibit the growth. In vivo it has good efficacy.
Patricia E B Verwer, Marian T ten Kate, Franco H Falcone, Shaun Morroll, Henri A Verbrugh, Irma A J M Bakker-Woudenberg, Wendy W J van de Sande   +6 more
doaj   +1 more source

A Linear 19-Mer Plant Defensin-Derived Peptide Acts Synergistically with Caspofungin against Candida albicans Biofilms

Frontiers in Microbiology, 2017
Public health problems are associated with device-associated biofilm infections, with Candida albicans being the major fungal pathogen. We previously identified potent antibiofilm combination treatment in which the antifungal plant defensin HsAFP1 is co ...
Tanne L. Cools, Caroline Struyfs, Caroline Struyfs, Jan W. Drijfhout, Soňa Kucharíková, Soňa Kucharíková, Celia Lobo Romero, Celia Lobo Romero, Patrick Van Dijck, Patrick Van Dijck, Marcelo H. S. Ramada, Marcelo H. S. Ramada, Carlos Bloch, Bruno P. A. Cammue, Bruno P. A. Cammue, Karin Thevissen   +15 more
doaj   +1 more source

Cellular apoptosis: An alternative mechanism of action for caspofungin against Candida glabrata [PDF]

Current Medical Mycology, 2019
Background and Purpose: Although the mechanism of action for echinocandins is known, the physiological mechanisms by which these antifungal agents cause cell death via the classical apoptotic pathways are not well-defined yet. Regarding this, the present
Parisa Aryamloo, Hossein Asgarian-Omran, Narges Aslani, Hadi Hossein-Nataj, Tahereh Shokohi, Hamid Badali, Mojtaba Nabili, Atefeh Abdollahi Gohar, Maryam Moazeni   +8 more
doaj   +1 more source