Results 11 to 20 of about 29,420 (294)
Antibiotics, 2022 Candida auris is a potential multidrug-resistant pathogen able to cause biofilm-associated outbreaks, where frequently indwelling devices are the source of infections.
Noémi Balla +9 more
doaj +2 more sources
Caspofungin-induced β(1,3)-glucan exposure in Candida albicans is driven by increased chitin levels
mBio, 2023 To successfully induce disease, Candida albicans must effectively evade the host immune system. One mechanism used by C. albicans to achieve this is to mask immunogenic β(1,3)-glucan epitopes within its cell wall under an outer layer of mannosylated ...
Andrew S. Wagner +3 more
doaj +2 more sources
Nonstationary Pharmacokinetics of Caspofungin in ICU Patients [PDF]
Antimicrobial Agents and Chemotherapy, 2020 Standard dosing of caspofungin in critically ill patients has been reported to result in lower drug exposure, which can lead to subtherapeutic 24-h area under the curve to MIC (AUC0–24/MIC) ratios. The aim of the study was to investigate the population pharmacokinetics of caspofungin in a cohort of 30 intensive care unit patients with a suspected ...
Agnieszka Borsuk-De Moor +8 more
openaire +4 more sources
Stimulation of Eryptosis by Caspofungin [PDF]
Cellular Physiology and Biochemistry, 2016 Background/Aims: The echinocandin antifungal agent caspofungin has been shown to trigger apoptosis of fungal cells. Beyond that, caspofungin is toxic for host mitochondria.
Thomas Peter +2 more
doaj +4 more sources
Phosphoproteomics of
mSphere, 2020 Aspergillus fumigatus is an opportunistic and allergenic pathogenic fungus, responsible for fungal infections in humans. A. fumigatus infections are usually treated with polyenes, azoles, or echinocandins.
Eliciane Cevolani Mattos +2 more
doaj +2 more sources
mBio, 2020 Aspergillus fumigatus is the leading cause of pulmonary fungal diseases. Azoles have been used for many years as the main antifungal agents to treat and prevent invasive aspergillosis.
Clara Valero +15 more
doaj +2 more sources
Clinical Infectious Diseases, 2003 Caspofungin, the first inhibitor of fungal beta-1,3 glucan synthesis to receive approval by the United States Food and Drug Administration, is effective for the treatment of mucosal and invasive candidiasis and invasive aspergillosis. It is also active in vitro and in animal models against a number of other filamentous and dimorphic endemic fungi and ...
Louis D. Saravolatz +2 more
openalex +3 more sources
mSphere, 2020 The cell wall-targeting echinocandin antifungals, although potent and well tolerated, are inadequate in treating fungal infections due to their narrow spectrum of activity and their propensity to induce pathogen resistance.
Siddharth K. Tripathi +12 more
doaj +2 more sources
Caspofungin acetate: An antifungal agent [PDF]
American Journal of Health-System Pharmacy, 2001 The pharmacology, bioavailability and pharmacokinetics, clinical efficacy, and adverse effects of caspofungin acetate are reviewed. Caspofungin acetate is an echinocandin with fungicidal activity against a wide range of pathogens, including Candida spp., Aspergillus spp., and Histoplasma spp.
openalex +4 more sources
Encephalopathy and Endophthalmitis Following Device-Related Invasive <i>Clavispora Lusitaniae</i> Infection in an Immunocompetent Patient: A Case Report. [PDF]
Clin Case RepABSTRACT Device‐related Candida infections are becoming more prevalent, even among immunocompetent individuals. For patients diagnosed with invasive candidiasis, it is essential to perform a fundoscopic examination, irrespective of the presence of ocular symptoms.
Cui Y +13 more
europepmc +2 more sources