Deletion of AIF1 but not of YCA1/MCA1 protects Saccharomyces cerevisiae and Candida albicans cells from caspofungin-induced programmed cell death [PDF]
Microbial Cell, 2014 Caspofungin was the first member of a new class of antifungals called echinocandins to be approved by a drug regulatory authority. Like the other echinocandins, caspofungin blocks the synthesis of β(1,3)-D-glucan of the fungal cell wall by inhibiting the
Christopher Chin +5 more
doaj +9 more sources
Caspofungin pharmacokinetics and probability of target attainment in ICU patients in China
Journal of Global Antimicrobial Resistance, 2021 : Objectives: Effective antifungal therapy is important to reduce mortality in patients with invasive fungal infections (IFIs). Numerous factors affect pharmacokinetic/pharmacodynamic (PK/PD) parameters in critically-ill patients.
Fangyi Li +5 more
doaj +2 more sources
Comparative efficacy and safety of topical caspofungin 0.5% and voriconazole 1% for fungal keratitis: a pilot clinical trial [PDF]
Scientific ReportsTo compare the efficacy of topical caspofungin 0.5% with topical voriconazole 1% in patients with fungal keratitis. In this pilot clinical trial, thirty-four eyes from 34 patients diagnosed with fungal keratitis, confirmed by positive smear or culture ...
Mehrnaz Atighehchian +6 more
doaj +2 more sources
Caspofungin binding to iron compromises its antifungal efficacy against Candida albicans [PDF]
Communications BiologyEchinocandins, which inhibit the synthesis of β-1,3-D-glucans, essential components of the fungal cell wall, are frontline drugs for invasive fungal infections (IFIs) caused by Candida spp.
Andreia Pedras +12 more
doaj +2 more sources
Evidence supporting a role for mammalian chitinases in efficacy of caspofungin against experimental aspergillosis in immunocompromised rats. [PDF]
PLoS ONE, 2013 Caspofungin, currently used as salvage therapy for invasive pulmonary aspergillosis (IPA), strangely only causes morphological changes in fungal growth in vitro but does not inhibit the growth. In vivo it has good efficacy.
Patricia E B Verwer +6 more
doaj +8 more sources
Predictors of caspofungin exposure-response relationship: a retrospective cohort study on therapeutic drug monitoring parameters [PDF]
Frontiers in PharmacologyIntroductionThis study aimed to characterize the exposure-response relationship of caspofungin through analysis of trough serum concentration (Cmin) associated with clinical efficacy, while identifying clinically determinants of Cmin.MethodsA single ...
Mingwei Meng +7 more
doaj +2 more sources
Caspofungin Combined With TMP/SMZ in Treatment of Intractable Acute Pneumocystis jirovecii Pneumonia in Renal Transplant Recipients: Case Report and Literature Review [PDF]
Clinical Case ReportsPneumocystis jirovecii pneumonia (PJP) is a potential life‐threatening opportunistic infection that predominantly affects immunocompromised individuals, such as those with human immunodeficiency virus or organ transplant recipients. The treatment of PJP,
Hongtao Hu +5 more
doaj +2 more sources
International Journal of Infectious Diseases, 2022 Objectives: Increased resistance of Candida species, especially Candida. glabrata is problematic. Combination antifungal therapies were studied to solve the problem.
Qianting Yang +6 more
doaj +1 more source
Microbiology Spectrum, 2022 Candida species are the main fungal opportunistic pathogens causing systemic infections that are often associated with drug resistance and biofilm production on medical devices.
Roberta Fais +4 more
doaj +1 more source
Gross karyotypic and phenotypic alterations among different progenies of the candida glabrata cbs138/atcc2001 reference strain [PDF]
, 2012 Peer reviewedPublisher ...
Bader, Oliver +8 more
core +12 more sources