Results 31 to 40 of about 29,725 (304)

In vitro and in vivo interaction of caspofungin with isavuconazole against Candida auris planktonic cells and biofilms

bioRxiv, 2021
The in vitro and in vivo efficacy of caspofungin was determined in combination with isavuconazole against Candida auris. Drug–drug interactions were assessed utilising the fractional inhibitory concentration indices (FICIs), the Bliss independence model ...
F. Nagy, Zoltán Tóth, Fanni Nyikos, Lajos Forgács, Á. Jakab, A. Borman, L. Majoros, R. Kovács   +7 more
semanticscholar   +1 more source

Pharmacokinetics of caspofungin in ICU patients [PDF]

Journal of Antimicrobial Chemotherapy, 2014
Caspofungin is used for treatment of invasive fungal infections. As the pharmacokinetics (PK) of antimicrobial agents in critically ill patients can be highly variable, we set out to explore caspofungin PK in ICU patients.ICU patients receiving caspofungin were eligible.
Muilwijk, E.W., Schouten, J.A., Leeuwen, H.J. van, Zanten, A.R. van, Lange, D.W. de, Colbers, A., Verweij, P.E., Burger, D.M., Pickkers, P., Bruggemann, R.J.M.   +9 more
openaire   +4 more sources

Heterogeneity in the transcriptional response of the human pathogen Aspergillus fumigatus to the antifungal agent caspofungin

bioRxiv, 2021
Aspergillus fumigatus is the main causative agent of invasive pulmonary aspergillosis (IPA), a severe disease that affects immunosuppressed patients worldwide.
A. C. Colabardini, Fang Wang, Zhiqiang Dong, Lakhansing Pardeshi, M. C. Rocha, J. H. Costa, T. F. dos Reis, Alec Brown, Qais Z. Jaber, M. Fridman, T. Fill, A. Rokas, I. Malavazi, K. H. Wong, G. Goldman   +14 more
semanticscholar   +1 more source

Development of Antifungal Peptides against Cryptococcus neoformans; Leveraging Knowledge about the cdc50Δ Mutant Susceptibility for Lead Compound Development

Microbiology Spectrum, 2022
Cryptococcus neoformans is a major fungal pathogen that often causes life-threatening meningitis in immunocompromised populations. This yeast pathogen is highly resistant to the echinocandin drug caspofungin.
Robert J. Tancer, Yina Wang, Siddhi Pawar, Chaoyang Xue, Gregory R. Wiedman   +4 more
doaj   +1 more source

In Vitro Interaction and Killing-Kinetics of Amphotericin B Combined with Anidulafungin or Caspofungin against Candida auris

Pharmaceutics, 2021
Treatment of invasive infections caused by Candida auris is challenging due to the limited therapeutic options. The combination of antifungal drugs may be an interesting and feasible approach to be investigated.
Unai Caballero, E. Eraso, G. Quindós, N. Jauregizar   +3 more
semanticscholar   +1 more source

Cellular apoptosis: An alternative mechanism of action for caspofungin against Candida glabrata [PDF]

Current Medical Mycology, 2019
Background and Purpose: Although the mechanism of action for echinocandins is known, the physiological mechanisms by which these antifungal agents cause cell death via the classical apoptotic pathways are not well-defined yet. Regarding this, the present
Parisa Aryamloo, Hossein Asgarian-Omran, Narges Aslani, Hadi Hossein-Nataj, Tahereh Shokohi, Hamid Badali, Mojtaba Nabili, Atefeh Abdollahi Gohar, Maryam Moazeni   +8 more
doaj   +1 more source

Quantitative Analysis of Candida Cell Wall Components by Flow Cytometrywith Triple-Fluorescence Staining [PDF]

, 2017
This work was supported by the European Commission within the FP7 Framework Programme [Fungitect-Grant No 602125]. We also thank Thomas Sauer, Vienna Biocenter Campus (VBC), Austria, for technical support at the FACS facility of the MFPL, Karl Kuchler ...
Gow, N, Istel, F, Jenull, S, Lion, T, Nogueira, MF, Walker, L A   +5 more
core   +1 more source

Absent in vitro interaction between chloroquine and antifungals against Aspergillus fumigatus [PDF]

, 2017
This work was supported by Medical Mycology Section, Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, the Netherlands.
Seyedmousavi, Seyedmojtaba, van der Lee, Henrich, Verweij, Paul, Warris, Adilia   +3 more
core   +1 more source

Human tissue distribution of caspofungin

International Journal of Antimicrobial Agents, 2022
Tissue concentrations of caspofungin were determined in nine clinically relevant tissues taken during routine autopsy of 20 patients who had died during caspofungin treatment or within 23 days of cessation. The highest levels were achieved in liver, with concentrations ranging from ≤0.50 to 91.5 µg/g (0.60 µg/g 21 days after the last administration ...
Jana Marx, Vera Reinstadler, Tiziana Gasperetti, René Welte, Herbert Oberacher, Patrizia Moser, Michael Joannidis, Romuald Bellmann   +7 more
openaire   +2 more sources

A Linear 19-Mer Plant Defensin-Derived Peptide Acts Synergistically with Caspofungin against Candida albicans Biofilms

Frontiers in Microbiology, 2017
Public health problems are associated with device-associated biofilm infections, with Candida albicans being the major fungal pathogen. We previously identified potent antibiofilm combination treatment in which the antifungal plant defensin HsAFP1 is co ...
Tanne L. Cools, Caroline Struyfs, Caroline Struyfs, Jan W. Drijfhout, Soňa Kucharíková, Soňa Kucharíková, Celia Lobo Romero, Celia Lobo Romero, Patrick Van Dijck, Patrick Van Dijck, Marcelo H. S. Ramada, Marcelo H. S. Ramada, Carlos Bloch, Bruno P. A. Cammue, Bruno P. A. Cammue, Karin Thevissen   +15 more
doaj   +1 more source