Results 61 to 70 of about 29,725 (304)

Efficacy and safety of caspofungin for patients with hepatic insufficiency

BMC Infectious Diseases, 2022
Background To observe the changes of hepatic function and efficacy of conventional dosage of caspofungin in the treatment of patients with different Child–Pugh scores.
Xiaoyun Ran, Pengfei Wang, An Zhang, Binfei Tang   +3 more
doaj   +1 more source

Polymorphic α‐Glucans as Structural Scaffolds in Cryptococcus Cell Walls for Chitin, Capsule, and Melanin: Insights From 13C and 1H Solid‐State NMR

Angewandte Chemie, Volume 137, Issue 36, September 1, 2025.
Cryptococcus neoformans cell wall α‐1,3‐glucans as dual anchors for melanin and capsule: Solid‐state NMR of intact C. neoformans cells reveals five forms of α‐1,3‐glucans that structurally bridge melanin and capsule layers. These polysaccharides interact with chitin, chitosan, and β‐glucans to create a molecular scaffold that underlies virulence and ...
Ankur Ankur, Jayasubba Reddy Yarava, Isha Gautam, Faith J. Scott, Frederic Mentink‐Vigier, Christine Chrissian, Li Xie, Dibakar Roy, Ruth E. Stark, Tamara L. Doering, Ping Wang, Tuo Wang   +11 more
wiley   +2 more sources

PD-1 blockade improves survival and fungal clearance, induces pro-inflammatory lung cytokines and synergizes with caspofungin in a pulmonary aspergillosis model.

Journal of Infectious Diseases, 2020
Pharmacological immune checkpoint blockade has revolutionized oncological therapies and its remarkable success has sparked interest in expanding checkpoint inhibitor therapy in infectious diseases.
S. Wurster, P. Robinson, N. Albert, J. Tarrand, Marisa A. Goff, M. Swamydas, Jean K. Lim, M. Lionakis, D. Kontoyiannis   +8 more
semanticscholar   +1 more source

The Fungal Cell Wall : Structure, Biosynthesis, and Function [PDF]

, 2017
N.G. is funded by the Wellcome Trust via a senior investigator award and a strategic award and by the MRC Centre for Medical Mycology. C.M. acknowledges the support of the Wellcome Trust and the MRC. N.G. and C.M.
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core   +1 more source

Outcomes by Candida spp. in the ReSTORE Phase 3 trial of rezafungin versus caspofungin for candidemia and/or invasive candidiasis

Antimicrobial Agents and Chemotherapy
Rezafungin is a long-acting, intravenously administered echinocandin for the treatment of candidemia and invasive candidiasis (IC). Non-inferiority of rezafungin vs caspofungin for the treatment of adults with candidemia and/or IC was demonstrated in the
J. B. Locke, C. Pillar, M. Castanheira, C. Carvalhaes, David R. Andes, J. Aram, Christina Andrzejewski, Ken Bartizal, Anita F Das, T. Sandison, George R. Thompson, Peter G. Pappas   +11 more
semanticscholar   +1 more source

Cell wall composition and biofilm formation of azoles-susceptible and -resistant Candida glabrata strains [PDF]

, 2011
In the present study, three strains of Candida glabrata have been investigated to shed light on the mechanisms involved in azole resistance during adherence and biofilm formation.
Vitali, Alberto, Vavala, Elisabetta, Marzano, Valeria, Leone, Claudia, Castagnola, Massimo, Iavarone, Federica, Angiolella, Letizia   +6 more
core   +5 more sources

Novel and potent antimicrobial effects of caspofungin on drug-resistant Candida and bacteria

Scientific Reports, 2020
Echinocandins, including caspofungin, micafungin, and anidulafungin, are first-line antifungal agents for the treatment of invasive candidiasis. They exhibit fungicidal activity by inhibiting the synthesis of β-1,3-d-glucan, an essential component of the
Makoto Sumiyoshi, T. Miyazaki, J. Makau, S. Mizuta, Yoshimasa Tanaka, Takeshi Ishikawa, K. Makimura, T. Hirayama, T. Takazono, Tomomi Saijo, H. Yamaguchi, Shintaro Shimamura, Kazuko Yamamoto, Y. Imamura, N. Sakamoto, Y. Obase, K. Izumikawa, K. Yanagihara, S. Kohno, H. Mukae   +19 more
semanticscholar   +1 more source

Candida auris, what do paediatricians need to know? [PDF]

, 2018
AW is supported by the Wellcome Trust Strategic Award (grant 097377) and the MRC Centre for Medical Mycology (grant MR/N006364/1) at the University of Aberdeen.Peer reviewedPublisher ...
Warris, Adilia
core   +1 more source

An expanded cell wall damage signaling network is comprised of the transcription factors Rlm1 and Sko1 in Candida albicans.

PLoS Genetics, 2020
The human fungal pathogen Candida albicans is constantly exposed to environmental challenges impacting the cell wall. Signaling pathways coordinate stress adaptation and are essential for commensalism and virulence.
Marienela Y Heredia, Mélanie A C Ikeh, Deepika Gunasekaran, Karen A Conrad, Sviatlana Filimonava, Dawn H Marotta, Clarissa J Nobile, Jason M Rauceo   +7 more
doaj   +1 more source

Caspofungin Use in Daily Clinical Practice for Treatment of Invasive Aspergillosis: Results of a Prospective Observational Registry

BMC Infectious Diseases, 2010
Background A prospective observational registry assessed real world experience with caspofungin monotherapy or combination therapy for the initial or salvage treatment of proven or probable invasive aspergillosis (IA).
Chandwani Sheenu, Stek Michael, Reichert Dietmar, Shin Wan, Maertens Johan, Egerer Gerlinde, Shivaprakash Malathi, Viscoli Claudio   +7 more
doaj   +1 more source