Results 61 to 70 of about 29,420 (294)

Caspofungin in the treatment of candidosis and aspergillosis

International Journal of Infectious Diseases, 2003
Antifungal agents can be classified by their site of action in fungal cells, which can have important implications for both efficacy and tolerability. Currently available agents include the polyenes, nucleoside analogs, and the azoles. With the exception of 5-fluorocytosine, all agents act by interfering with the structural or functional integrity of ...
Johan Maertens, Marc Boogaerts
openaire   +3 more sources

Hsp21potentiates antifungal drug tolerance in Candida albicans [PDF]

, 2013
Peer reviewedPublisher ...
Alix Therese Coste, B Enjalbert, B Enjalbert, B Wachtler, Bernhard Hube, C Fradin, C Onyewu, C Onyewu, D Harcus, Duncan Wilson, F Abe, F Ritossa, FL Mayer, François L. Mayer, G Kappe, H Senn, HJ Lo, ID Jacobsen, J Buchner, JA Lewis, K Richter, K Zakikhany, L Whitesell, LE Cowen, LE Cowen, LE Cowen, LE Cowen, LE Cowen, M Lis, M Ramsdale, M Taipale, M Taipale, MA Pfaller, MA Pfaller, MC Cruz, MC Lorenz, MS Fu, N Booth, N Robbins, P Uppuluri, RK Swoboda, RS Shapiro, RS Shapiro, RS Shapiro, RS Shapiro, S Diezmann, S Hodgetts, S Lindquist, S Nicholls, S Thewes, SD Singh, SL LaFayette, WJ Steinbach   +52 more
core   +2 more sources

PD-1 blockade improves survival and fungal clearance, induces pro-inflammatory lung cytokines and synergizes with caspofungin in a pulmonary aspergillosis model.

Journal of Infectious Diseases, 2020
Pharmacological immune checkpoint blockade has revolutionized oncological therapies and its remarkable success has sparked interest in expanding checkpoint inhibitor therapy in infectious diseases.
S. Wurster, P. Robinson, N. Albert, J. Tarrand, Marisa A. Goff, M. Swamydas, Jean K. Lim, M. Lionakis, D. Kontoyiannis   +8 more
semanticscholar   +1 more source

Disseminated candidemia refractory to caspofungin therapy in an infant with extremely low birth weight

Journal of the Formosan Medical Association, 2012
Systemic fungal infections have high morbidity and mortality rates in neonates, especially neonates with an extremely low birth weight (ELBW). Here, we describe a 21-day-old ELBW female infant with an amphotericin B-unresponsive congenital Candida ...
Meng-Ju Li, Po-Ren Hsueh, Chun-Yi Lu, Hung-Chieh Chou, Ping-Ing Lee, Luan-Yin Chang, Li-Min Huang   +6 more
doaj   +1 more source

Outcomes by Candida spp. in the ReSTORE Phase 3 trial of rezafungin versus caspofungin for candidemia and/or invasive candidiasis

Antimicrobial Agents and Chemotherapy
Rezafungin is a long-acting, intravenously administered echinocandin for the treatment of candidemia and invasive candidiasis (IC). Non-inferiority of rezafungin vs caspofungin for the treatment of adults with candidemia and/or IC was demonstrated in the
J. B. Locke, C. Pillar, M. Castanheira, C. Carvalhaes, David R. Andes, J. Aram, Christina Andrzejewski, Ken Bartizal, Anita F Das, T. Sandison, George R. Thompson, Peter G Pappas   +11 more
semanticscholar   +1 more source

Two cases of fungal keratitis caused by Metarhizium anisopliae [PDF]

, 2018
We present two cases of keratitis due to Metarhizium anisopliae in geographically separated areas of the United States. The isolates were microscopically similar but morphologically different and were identified by ribosomal DNA sequencing. Both isolates
Burd, Eileen M, Burnham, Carey-Ann D, Goodman, Abigail L, Lockhart, Shawn R, Lysen, Colleen B, Westblade, Lars F   +5 more
core   +2 more sources

Isavuconazole Versus Caspofungin in the Treatment of Candidemia and Other Invasive Candida Infections: The ACTIVE Trial.

Clinical Infectious Diseases, 2018
BACKGROUND Isavuconazole was compared to caspofungin followed by oral voriconazole in a Phase 3, randomized, double-blind, multinational clinical trial for the primary treatment of patients with candidemia or invasive candidiasis.
B. Kullberg, C. Viscoli, P. Pappas, J. Vázquez, L. Ostrosky-Zeichner, C. Rotstein, J. Sobel, R. Herbrecht, G. Rahav, S. Jaruratanasirikul, P. Chetchotisakd, E. Van Wijngaerden, J. D. De Waele, C. Lademacher, M. Engelhardt, L. Kovanda, R. Croos-Dabrera, Christine Fredericks, G. Thompson   +18 more
semanticscholar   +1 more source

Novel and potent antimicrobial effects of caspofungin on drug-resistant Candida and bacteria

Scientific Reports, 2020
Echinocandins, including caspofungin, micafungin, and anidulafungin, are first-line antifungal agents for the treatment of invasive candidiasis. They exhibit fungicidal activity by inhibiting the synthesis of β-1,3-d-glucan, an essential component of the
Makoto Sumiyoshi, T. Miyazaki, J. Makau, S. Mizuta, Yoshimasa Tanaka, Takeshi Ishikawa, K. Makimura, T. Hirayama, T. Takazono, Tomomi Saijo, H. Yamaguchi, Shintaro Shimamura, Kazuko Yamamoto, Y. Imamura, N. Sakamoto, Y. Obase, K. Izumikawa, K. Yanagihara, S. Kohno, H. Mukae   +19 more
semanticscholar   +1 more source

Medication Complications in Extracorporeal Membrane Oxygenation. [PDF]

, 2017
The need for extracorporeal membrane oxygenation (ECMO) therapy is a marker of disease severity for which multiple medications are required. The therapy causes physiologic changes that impact drug pharmacokinetics.
Aebi, Ami G. Shah, Anderson, Arlt, Barr, Barthelemy, Beiderlinden, Bein, Bembea, Bhatt-Meht, Boucher, Brandi N. Thoma, Brown, Buck, Buscher, Chung, Dagan, Dagan, de Montmollin, De Rosa, DeGrado, Donadello, Donadello, Dzierba, Erstad, Esper, Eyler, Flordelis Lasierra, Glauber, Greenberg, Gélisse, Hadidi, Hertzog, Hraiech, Hynynen, Johnston, Kawada, Kim, Koster, Krueger, Lamarche, Latronico, Lemaitre, Levison, Malfertheiner, Mehta, Michelle Peahota, Moore, Mousavi, Mulla, Mulla, Muntean, Oliver, Paden, Park, Perkins, Peters, Pettignano, Phillips, Pieri, Potter, Preston, Protti, Ranucci, Riker, Roberts, Roos, Rosen, Ruiz, Rybak, Saini, Sanfilippo, Satyapriya, Schmith, Shekar, Shekar, Shekar, Shekar, Shekar, Sherwin, Sklar, Smith, Spriet, Staudacher, Strunk, Subramaniam, Szefner, Tellor, Trudzinski, Tulman, Turner, Veinstein, Vilay, Wagner, Walter K. Kraft, Welsch, Wen, Wildschut, Wu, Young   +99 more
core   +2 more sources

A Randomized Trial of Caspofungin vs Triazoles Prophylaxis for Invasive Fungal Disease in Pediatric Allogeneic Hematopoietic Cell Transplant.

Journal of the Pediatric Infectious Diseases Society, 2020
BACKGROUND Children and adolescents undergoing allogeneic hematopoietic cell transplantation (HCT) are at high risk for invasive fungal disease (IFD). METHODS This multicenter, randomized, open-label trial planned to enroll 560 children and adolescents
C. Dvorak, B. Fisher, A. Esbenshade, M. Nieder, S. Alexander, W. Steinbach, H. Dang, D. Villaluna, Lu Chen, M. Skeens, T. Zaoutis, L. Sung   +11 more
semanticscholar   +1 more source