Results 31 to 40 of about 219,417 (396)

Nonmetastatic, Castration-Resistant Prostate Cancer and Survival with Darolutamide.

New England Journal of Medicine, 2020
BACKGROUND Darolutamide is a structurally distinct androgen-receptor inhibitor that is approved for the treatment of nonmetastatic, castration-resistant prostate cancer.
K. Fizazi, N. Shore, T. Tammela, A. Ulys, E. Vjaters, S. Polyakov, M. Jievaltas, M. Luz, B. Alekseev, I. Kuss, M. Le Berre, O. Petrenciuc, A. Snapir, T. Sarapohja, Matthew R. Smith   +14 more
semanticscholar   +1 more source

Case Report: Successful Management and Long-Term Follow-Up of Bilateral Ureteral Ligation in a Dog Secondary to Cryptorchid Castration Utilizing Bilateral Ureteral Stents and a Neoureterocystostomy Procedure

Frontiers in Veterinary Science, 2022
ObjectiveTo report the successful management of the bilateral ureteral obstruction secondary to ureteral ligation during unilateral cryptorchid surgery in a dog with the utilization of bilateral ureteral stent placement and a neoureterocystostomy ...
Rebecca Walton, Megan Mickelson, Jean-Sebastien Palerme, April Blong, Meredith 't Hoen   +4 more
doaj   +1 more source

Advances in targeted Alpha therapy for prostate cancer [PDF]

, 2019
BACKGROUND: Amongst therapeutic radiopharmaceuticals, targeted alpha therapy (TαT) can deliver potent and local radiation selectively to cancer cells as well as the tumor microenvironment and thereby control cancer while minimizing toxicity.
De Vincentis, G, Gerritsen, W, Gschwend, JE, Hacker, M, Lewington, V, O'Sullivan, JM, Oya, M, Pacilio, M, Parker, C, Sartor, O, Shore, N, Targeted Alpha Therapy Prostate Working Group   +11 more
core   +2 more sources

Recognizing Post-Castration Pain in Piglets: A Survey of Swine Industry Stakeholders and the General Public

Frontiers in Animal Science, 2022
We need validated, practical methods for pain assessment in piglets. Pain assessment can help researchers, veterinarians and industry professionals identify the need for analgesia or other pain management approaches when applying painful procedures, such
Jessica M. Neary, Nathaniel D. Porter, Nathaniel D. Porter, Abbie V. Viscardi, Leonie Jacobs   +4 more
doaj   +1 more source

Leaders should not be conformists in evolutionary social dilemmas [PDF]

Sci. Rep. 6 (2016) 23633, 2016
The most common assumption in evolutionary game theory is that players should adopt a strategy that warrants the highest payoff. However, recent studies indicate that the spatial selection for cooperation is enhanced if an appropriate fraction of the population chooses the most common rather than the most profitable strategy within the interaction ...
arxiv   +1 more source

Identification of LIMK2 as a therapeutic target in castration resistant prostate cancer [PDF]

, 2019
This study identified LIMK2 kinase as a disease-specific target in castration resistant prostate cancer (CRPC) pathogenesis, which is upregulated in response to androgen deprivation therapy, the current standard of treatment for prostate cancer. Surgical
Broman, Meaghan M., Chang, Lei, Chowdhury, Dipanjan, Cresswell, Gregory, He, Yizhou J., Jacobsen, Max, McGuire, Callista, Nikhil, Kumar, Ratliff, Timothy L., Sandusky, George E., Satapathy, Shakti R., Shah, Kavita, Tandiary, Michael, Viccaro, Keith   +13 more
core   +1 more source

Defining the pig microglial transcriptome reveals its core signature, regional heterogeneity, and similarity with human and rodent microglia

Glia, Volume 71, Issue 2, Page 334-349, February 2023., 2023
Main Points Defined a pig microglial transcriptome signature comprising 239 genes. Demonstrated regional variance in the pig microglial transcriptome across the brain. Revealed similarity of pig microglial gene expression to that of human and mouse microglia.
Barbara B. Shih, Sarah M. Brown, Jack Barrington, Lucas Lefevre, Neil A. Mabbott, Josef Priller, Gerard Thompson, Alistair B. Lawrence, Barry W. McColl   +8 more
wiley   +1 more source

Juridical Review of Chemical Castration Action In The Perspective of Criminal Law And Human Rights

Yurisdiksi: Jurnal Wacana Hukum dan Sains, 2021
Children are a gift from God Almighty must be maintained for their survival because children are the future and next generation of the nation.  A state commits protecting the children's rights and ensuring children's welfare by issuing several laws and ...
Aulya Dwisudarini, Muridah Isnawati
doaj  

A survey of open questions in adaptive therapy: bridging mathematics and clinical translation [PDF]

arXiv, 2022
Adaptive therapy is a dynamic cancer treatment protocol that updates (or "adapts") treatment decisions in anticipation of evolving tumor dynamics. This broad term encompasses many possible dynamic treatment protocols of patient-specific dose modulation or dose timing.
arxiv  

A Phase I Study of Abiraterone Acetate Combined with BEZ235, a Dual PI3K/mTOR Inhibitor, in Metastatic Castration Resistant Prostate Cancer. [PDF]

, 2017
Lessons learnedThe combination of standard dose abiraterone acetate and BEZ235, a pan-class I PI3K and mTORC1/2 inhibitor, was poorly tolerated in men with progressive mCRPC.Although the clinical development of BEZ235 has been discontinued in prostate ...
Friedlander, Terence, Hsieh, Andrew C, Kim, Won, Lin, Amy M, Louttit, Mirela, Ryan, Charles J, Wei, Xiao X   +6 more
core   +1 more source