Results 31 to 40 of about 174,818 (337)

Defective DNA repair mechanisms in prostate cancer: impact of olaparib [PDF]

, 2017
The field of prostate oncology has continued to change dramatically. It has truly become a field that is intensely linked to molecular genetic alterations, especially DNA-repair defects.
De Felice, Francesca, Marampon, Francesco, Marchetti, Claudia, Musella, Angela, Tombolini, Vincenzo   +4 more
core   +2 more sources

Identification of LIMK2 as a therapeutic target in castration resistant prostate cancer [PDF]

, 2019
This study identified LIMK2 kinase as a disease-specific target in castration resistant prostate cancer (CRPC) pathogenesis, which is upregulated in response to androgen deprivation therapy, the current standard of treatment for prostate cancer. Surgical
Broman, Meaghan M., Chang, Lei, Chowdhury, Dipanjan, Cresswell, Gregory, He, Yizhou J., Jacobsen, Max, McGuire, Callista, Nikhil, Kumar, Ratliff, Timothy L., Sandusky, George E., Satapathy, Shakti R., Shah, Kavita, Tandiary, Michael, Viccaro, Keith   +13 more
core   +1 more source

The Effect of Behavioural Indicators of Calf Discomfort Following Routine Procedures on Cow Maternal Care

Animals, 2020
Pain causes altered arousal and specific behaviours that are rare at other times (pain indicators). We examined whether beef cows (mean age 6 years) are sensitive to pain indicators in addition to arousal following ear tagging and rubber ring castration (
Simon P. Turner, Kirstin McIlvaney, Jo Donbavand, Matt J. Turner   +3 more
doaj   +1 more source

Boar taint – possibilities and solutions in pig production [PDF]

Poljoprivreda, 2016
Over many years castration of male pigs has been a common zootechnical practice performed in order to avoid boar taint or offensive odour of pork found in sexually mature boars.
Boris Lukić, Emilija Cimerman, Nikola Raguž, Ivona Djurkin Kušec, Suzanne Rowe, Goran Kušec   +5 more
doaj   +1 more source

Review of Eunuchs and Castrati: Disability and Normativity in Early Modern Europe by Katherine Crawford

Disability Studies Quarterly, 2021
No abstract available.
Turnip Van Dyke
doaj   +1 more source

Effects of lidocaine-plus-meloxicam treatment on behavioral and physiological changes, and leukocyte heat shock protein 90 gene expression after surgical castration in Hanwoo bulls

Frontiers in Veterinary Science
This study examined the effects of surgical castration and lidocaine-plus-meloxicam treatment on growth, physiology, behaviors, and leukocyte heat shock protein 90 (HSP 90) gene expression in Hanwoo (Korean cattle) bulls. Twenty Hanwoo bulls (body weight
Ingu Cho, Seonpil Yoo, Da Jin Sol Jung, Jaesung Lee, Seok-Hyeon Baek, Sang Yeob Kim, Jinoh Lee, Dohyun Kim, Hyun Jin Kim, Myunggi Baik, Myunggi Baik   +10 more
doaj   +1 more source

Inflammation and NF-κB Signaling in Prostate Cancer: Mechanisms and Clinical Implications

Cells, 2018
Prostate cancer is a highly prevalent form of cancer that is usually slow-developing and benign. Due to its high prevalence, it is, however, still the second most common cause of death by cancer in men in the West.
Jens Staal, Rudi Beyaert
doaj   +1 more source

Occupational markers and pathology of the castrato singer Gaspare Pacchierotti (1740\u20131821) [PDF]

, 2016
Following the birth of modern opera in Italy in 1600, the demand for soprano voices grew up and the prepuberal castration was carried out to preserve the young male voice into adult life.
RIPPA BONATI, Maurizio, Scattolin, Giuliano, Zampieri, Fabio, Zanatta, Alberto   +3 more
core   +2 more sources

Reasons for and Behavioral Consequences of Male Dog Castration—A Questionnaire Study in Poland

Animals, 2022
In many Western countries, castration is the most popular surgical desexing procedure in dogs. The aim of the study was to identify the reasons for male dog castration and to determine the owners’ perceptions about changes in dog behavior before and ...
Marcelina Kriese, Ewelina Kuźniewska, Andrzej Gugołek, Janusz Strychalski   +3 more
doaj   +1 more source

Real-world outcomes of sipuleucel-T treatment in PROCEED, a prospective registry of men with metastatic castration-resistant prostate cancer. [PDF]

, 2019
BackgroundThe large registry, PROVENGE Registry for the Observation, Collection, and Evaluation of Experience Data (PROCEED)(NCT01306890), evaluated sipuleucel-T immunotherapy for asymptomatic/minimally symptomatic metastatic castration-resistant ...
Armstrong, Andrew J, Chang, Nancy N, Concepcion, Raoul S, Cooperberg, Matthew R, Harmon, Matt, Higano, Celestia S, Kantoff, Philip W, Kassabian, Vahan, McLeod, David G, Nordquist, Luke T, Penson, David F, Pieczonka, Christopher M, Quinn, David I, Sartor, A Oliver, Scholz, Mark C, Shore, Neal D, Tang, Hong, Tutrone, Ronald F, Tyler, Robert C, Vacirca, Jeffrey, Vogelzang, Nicholas J   +20 more
core   +2 more sources