Results 81 to 90 of about 1,785 (172)

The protective effect and mechanism of catalpol on high glucose-induced podocyte injury

BMC Complementary and Alternative Medicine, 2019
Background Catalpol, a natural iridoid glycoside in Rehmannia glutinosa, can alleviate proteinuria associated with diabetic nephropathy (DN), however, whether catalpol has a protective effect against podocyte injury in DN remains unclear. Methods In this
Yan Chen, Qingpu Liu, Zengfu Shan, Yingying Zhao, Meng Li, Baiyan Wang, Xiaoke Zheng, Weisheng Feng   +7 more
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Catalpol Enhances Neurogenesis And Inhibits Apoptosis Of New Neurons Via BDNF, But Not The BDNF/Trkb Pathway

Drug Design, Development and Therapy, 2019
Hui-Feng Zhu,1,* Yali Shao,1,* Lei Qin,1,* Jing-Huan Wang,1 Shan Feng,1 Yun-Bin Jiang,1 Dong Wan2 1Department of Pharmacy, College of Pharmaceutical Sciences and Chinese Medicine, Southwest University, Chongqing 400715, People’s Republic of China ...
Zhu HF, Shao Y, Qin L, Wang JH, Feng S, Jiang YB, Wan D   +6 more
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Anti-inflammatory and Anti-endoplasmic reticulum stress Effects of catalpol Against myocardial ischemia-reperfusion injury in streptozotocin-induced diabetic rats [PDF]

Anais da Academia Brasileira de Ciências
The current study was designed to investigate the effects and the mechanism of catalpol on myocardial ischemia-reperfusion (MI/R) injury in a diabetic rat model.
FANGJIE BI, YUJIA XU, GUANGXIN CHEN, PAN WANG   +3 more
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Effect and Mechanism of Catalpol on Behavior in Rats with Post-stroke Depression

康复学报, 2022
ObjectiveTo explore the effect of catalpol on the behavior of post-stroke depression rats, and to explore its mechanism from the aspects of behavior, the expression of 5-hydroxytryptamine (5-HT), norepinephrine (NE) and brain-derived neurotrophic factor (
WANG Xiangyu, ZHOU Xia, LIU Ju, LIU Fuhong, ZHANG Jiale, SUN Liping, LI Wanbin   +6 more
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Catalpol Increases Brain Angiogenesis and Up-Regulates VEGF and EPO in the Rat after Permanent Middle Cerebral Artery Occlusion

International Journal of Biological Sciences, 2010
To investigate the role and mechanism of catalpol in brain angiogenesis in a rat model of stroke, the effect of catalpol (5 mg/kg; i.p) or vehicle administered 24 hours after permanent middle cerebral artery occlusion (pMCAO) on behavior, angiogenesis ...
Hui-Feng Zhu, Dong Wan, Yong Luo, Jia-Li Zhou, Li Chen, Xiao-Yu Xu
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Catalpol protects hepatopulmonary syndrome rats against liver and lung injury

陆军军医大学学报
Objective To explore the protective effect of catalpol by enhancing TGR5 expression and reducing bile acid (BAs) level against liver and lung injury in rats with common bile duct ligation (CBDL).
ZENG Ziyang, LEI Yuhao, WU Xianfeng
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Catalpol inhibits HHcy-induced EndMT in endothelial cells by modulating ROS/NF-κB signaling

BMC Cardiovascular Disorders
Background Hyperhomocysteinemia (HHcy) is an independent risk factor for atherosclerosis (AS). Endothelial mesenchymal transition (EndMT) refers to the process in which endothelial cells lose endothelial cell morphology and characteristic gene expression,
Chengyan Wu, Yuanhao Li, Shuangshuang Liu, Libo Wang, Xuehui Wang   +4 more
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Screening and Culture Condition Optimization of a Catalpol-Producing Brevundimonas olei

Microbiology Research
Catalpol, one of the primary bioactive components in Rehmannia glutinosa, is an iridoid glycoside with significant pharmacological activities. To expand the microbial sources of catalpol, endophytic bacteria were isolated from R. glutinosa (cultivated in
Jianmin Liu, Mingliang Geng, Yi Chen, Zhenhui Wang   +3 more
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Catalpol prevents denervated muscular atrophy related to the inhibition of autophagy and reduces BAX/BCL2 ratio via mTOR pathway

Drug Design, Development and Therapy, 2018
Yuan Wang,1,* Yali Shao,1 Yuqing Gao,1 Guoran Wan,2 Dong Wan,3,* Huifeng Zhu,1 Yan Qiu,1 Xiyue Ye1 1Department of Chinese Medicine, College of Pharmaceutical Sciences and Traditional Chinese Medicine, Southwest University, Chongqing Engineering Research
Wang Y, Shao YL, Gao YQ, Wan GR, Wan D, Zhu HF, Qiu Y, Ye XY   +7 more
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The Active Ingredient Catalpol in Rehmannia glutinosa Reduces Blood Glucose in Diabetic Rats via the AMPK Pathway

Diabetes, Metabolic Syndrome and Obesity
Yang Li,* Qiang Chen,* Hong-Juan Sun, Jian-Hong Zhang, Xuan Liu Pharmaceutical Preparation Section, the Fourth Central Hospital of Tianjin, Tianjin, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yang
Li Y, Chen Q, Sun HJ, Zhang JH, Liu X
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