CNS Neuroscience &Therapeutics, Volume 31, Issue 12, December 2025.Hypoxia induces HMGB1's nucleus‐to‐cytoplasm translocation, which binds to Nrf2 to repress Nrf2 nuclear translocation to suppress Nrf2/HO‐1 activation to promote NLRP3 inflammasome/Caspase‐1‐mediated pyroptosis, thereby exacerbating MIRI. ABSTRACT Objective Myocardial ischemia–reperfusion injury (MIRI) represents an inevitable risk event for acute ...
Fuzhen Zheng +7 more
wiley +1 more source
Protective effects of catalpol on mitochondria of hepatocytes in cholestatic liver injury
Molecular Medicine Reports, 2020 Cholestasis, which is caused by the obstruction of bile flow, can lead to rapid organ injury, cell apoptosis and necrosis of hepatocytes, and may eventually develop into fibrosis and cirrhosis. Oxidative stress and mitochondrial dysfunction are the key pathogenic signs of hepatic cholestasis.
Gao, Xingjuan, Xu, Jiaju, Liu, Hongbo
openaire +3 more sources
Catalpol ameliorates diabetic retinal vascular endothelial injury by suppressing NLRP3 inflammasome via targeting METTL3-m6A modification [PDF]
International Journal of OphthalmologyAIM: To investigate whether catalpol protects against diabetic retinal vascular endothelial injury by targeting the methyltransferase-like 3 (METTL3)-m6A-thioredoxin-interacting protein (TXNIP) axis and inhibiting nucleotide-binding oligomerization ...
Jing-Yu Liu +5 more
doaj +1 more source
Amelioration of Diabetic Mouse Nephropathy by Catalpol Correlates with Down-Regulation of Grb10 Expression and Activation of Insulin-Like Growth Factor 1 / Insulin-Like Growth Factor 1 Receptor Signaling. [PDF]
PLoS ONE, 2016 Growth factor receptor-bound protein 10 (Grb10) is an adaptor protein that can negatively regulate the insulin-like growth factor 1 receptor (IGF-1R).
Shasha Yang +11 more
doaj +1 more source
Role of Histone Deacetylase and Inhibitors in Cardiovascular Diseases
Cell Proliferation, Volume 58, Issue 12, December 2025.HDACs play an important role in the occurrence and development of cardiovascular diseases, such as myocardial hypertrophy, hypertension, and atherosclerosis. HDAC inhibitors have broad prospects for the treatment of CVD, and different HDAC subtypes can act through different mechanisms.
Li‐Ying Zhang +4 more
wiley +1 more source
Scientific Reports, 2023 Catalpol, a natural product mainly existed in plenty of Chinese traditional medicines, is an iridoid compound with the comprehensive effects on neuroprotective, anti-inflammatory, choleretic, hypoglycemic and anticancer.
Yuanfang Kong +8 more
doaj +1 more source
Traditional Chinese medicinal formula Si-Wu-Tang prevents oxidative damage by activating Nrf2-mediated detoxifying/antioxidant genes [PDF]
, 2014 BACKGROUND: Induction of Nrf2-mediated detoxifying/antioxidant genes has been recognized as an effective strategy for cancer chemoprevention. Si-Wu-Tang (SWT), comprising the combination of four herbs, Paeoniae, Angelicae, Chuanxiong and Rehmanniae, is ...
Arvind Thakkar +8 more
core +1 more source
Lipid nanoparticles loaded with iridoid glycosides: development and optimization using experimental factorial design [PDF]
, 2021 Lipid nanoparticles based on multiple emulsion (W/O/W) systems are suitable for incorporating hydrophilic active substances, including iridoid glycosides.
Dinda +11 more
core +1 more source
Advanced Science, Volume 12, Issue 43, November 20, 2025.Machine‐learning‐directed phytochemical pair ACT/FA, administered at BDD's orthodox ratio, synergistically modulates microglial polarization via dual Nrf2/RORγt targeting to attenuate neuroinflammation and depressive behaviors. This concentration‐dependent synergism replicates the parent formula's efficacy while providing a mechanistic basis for ...
Dongjing Guo +7 more
wiley +1 more source
In vitro study on the preparation of catalpol/GelMA hydrogel and its antioxidant properties
Kouqiang hemian waike zazhi[Objective:] To investigate the effects of catalpol on rat Schwann cell (RSC) and establish a catalpol/methacrylated gelatin (GelMA) hydrogel, followed by in vitro evaluation of its biocompatibility and antioxidant properties.
ZHANG Chunlei +6 more
doaj +1 more source