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Effects of Cobalt and Zinc Stress on Rehmannia glutinosa Growth, Bioactive Compounds, Antioxidant Activity, and Molecular Insights

New Zealand Journal of Crop and Horticultural Science, Volume 54, Issue 1, March 2026.
This study aimed to investigate the effects of cobalt (Co) and zinc (Zn) on the growth, antioxidant activity, total phenolic and flavonoid contents (TPC and TFC), targeted polyphenolic compounds, and molecular dynamics simulations of Rehmannia glutinosa (R. glutinosa) L.
Bimal Kumar Ghimire +9 more
wiley +1 more source

Research Progress on the Stability and Degradation Mechanism of Cistanche deserticola Active Compounds During Different Maturity, Preservation, and Processing

Journal of Food Processing and Preservation, Volume 2026, Issue 1, 2026.
Cistanche deserticola (CD) Y. C. Ma is a well‐known tonic medicinal material, and its clinical value and industrial development are highly dependent on the integrity of core pharmacodynamic components (such as phenylosides and polysaccharides). This article systematically reviews the impact of three key links: harvest maturity, postharvest preservation
Yao Zhang +7 more
wiley +1 more source

Quality Evaluation of Polygonum chinense From Different Origins Based on UPLC‐MS/MS, Chemical Pattern Recognition, Network Pharmacology, and Molecular Docking

Journal of Chemistry, Volume 2026, Issue 1, 2026.
Introduction Polygonum chinense L. (PCL) is a widely utilized traditional medicinal herb among the Zhuang ethnic group, as documented in the “Quality Standards of Zhuang Ethnic Medicine in Guangxi Zhuang Autonomous Region.” This plant is renowned for its therapeutic properties, including heat‐clearing, dampness elimination, blood cooling, and ...
Yuchen Shen, Xiuqi Yu, Zhonghua Dai, Fengfeng Xie +3 more
wiley +1 more source

Catalpol Confers Neuroprotection against Cerebral Ischemic Injury by Regulating the Phosphatidylinositol 3-Kinase/Protein Kinase B/Glycogen Synthase Kinase 3 Beta/β-Catenin Signaling Pathway

World Journal of Traditional Chinese Medicine
Background: Ischemic stroke is a leading cause of long-term neurological disability worldwide. Within minutes of its onset, blood flow to the brain’s ischemic core drops dramatically, resulting in irreversible damage and eventual neuronal death in the ...
Xiao-Yu Zheng +11 more
doaj +1 more source

Shao Di Pa Ning Decoction Attenuates Neuroinflammation in Parkinson’s Disease via PI3K/AKT Signaling Pathway

Mediators of Inflammation, Volume 2026, Issue 1, 2026.
Background Parkinson’s disease (PD) is a neurodegenerative disorder with limited therapeutic options. Shao Di Pa Ning Decoction (SDPND), a traditional Chinese medicine (TCM) compound formula for PD, has demonstrated therapeutic efficacy, but its underlying mechanisms remain unclear.
Peng Huang +13 more
wiley +1 more source

Analysis of Chemical Components and Blood‐Absorbed Components in Youjing Granules by UHPLC‐Q‐Orbitrap‐MS

Analytical Science Advances, Volume 6, Issue 2, December 2025.
ABSTRACT This study investigates the chemical components of Youjing Granules (YG) and identifies blood‐absorbed components in rat serum following YG administration via gavage. Chemical components and blood‐absorbed components of YG were analysed and identified using ultra‐high‐performance liquid chromatography coupled with hybrid quadrupole‐orbitrap ...
Mingxin Guo +5 more
wiley +1 more source

Recent advances in the multifaceted mechanisms of catalpol in treating osteoporosis

Frontiers in Pharmacology
Catalpol (CAT) is a landmark active ingredient in traditional Chinese medicine Rehmannia (TCT), also known as dehydroxybenzoate catalpone, which is a kind of iridoid terpene glycoside with strong antioxidant, anti-inflammatory, antitumor and other biological activities. It can exert its anti-disease effect in a variety of ways.
Na Li +3 more
openaire +3 more sources

Inhibition of Taq DNA polymerase by catalpol.

Cellular and molecular biology (Noisy-le-Grand, France), 2004
Fil: Ciuffo, Gladys Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas
Pungitore, Carlos Rodolfo +4 more
openaire +2 more sources

Catalpol reduced LPS induced BV2 immunoreactivity through NF-κB/NLRP3 pathways: an in Vitro and in silico study

Frontiers in Pharmacology
Background: Ischemic Stroke (IS) stands as one of the primary cerebrovascular diseases profoundly linked with inflammation. In the context of neuroinflammation, an excessive activation of microglia has been observed.
Yong She +5 more
doaj +1 more source

Ovarian Failure-Resistant Effects of Catalpol in Aged Female Rats

Biological and Pharmaceutical Bulletin, 2014
Catalpol, an iridoid glycoside obtained from various natural sources, has many biological functions. However, its ovarian failure-resistant effect has scarcely been studied. The present study used senile 14-month-old Sprague-Dawley female rats to examine the in vivo ovarian failure-resistant activity of catalpol. Daily oral graded doses of catalpol (1,
Wei, Min, Lu, Ye, Liu, Daniel, Ru, Wenwen +3 more
openaire +3 more sources

apoptosis
oxidative stress
inflammation

neuroprotection
autophagy
antioxidant

rehmannia glutinosa