Results 51 to 60 of about 3,043 (217)
Cell Proliferation, EarlyView.Polyamine metabolism is innervation responsive and involved in denervation‐induced muscle atrophy. Inhibition of polyamine metabolism attenuates muscle atrophy by restraining proteolysis and preserving MuSCs homeostasis. Denervation‐induced activation of FAP‐derived FGF7 drives premature MuSCs activation, while DFMO suppresses this paracrine cue to ...
Mingming Zhang +9 more
wiley +1 more source
Catalpol represses the migration, proliferation and epithelial mesenchymal transition of TGF β2 stimulated lens epithelial cells via TGF β/Smad and Notch1 signaling pathways [PDF]
, 2022 Purpose: To investigate the role of catalpol in posterior capsule opacification (PCO). Methods: Human lens epithelial cells (SRA01/04) were treated with TGF-β2 or co-treated with TGF-β2 and different concentrations of catalpol.
Li, Xiaoyu, Ma, Honglei
core +2 more sources
Plant Biotechnology Journal, Volume 24, Issue 6, Page 3708-3722, June 2026.ABSTRACT Iridoids constitute a prominent class of plant‐specialised metabolites, with carbocyclic iridoids (e.g., geniposide) and secoiridoids (e.g., loganin) diverging early in their biosynthetic pathways. This divergence is marked by substrate‐specific carboxyl methyltransferases—GjGAMT and CrLAMT—that catalyse the decisive methylation step in ...
Li Li +7 more
wiley +1 more source
Catalpol alleviates the lipopolysaccharide-induced inflammatory response of BV2 cells
Bangladesh Journal of PharmacologyThis study aimed to investigate the effect of catalpol on the inflammatory response of murine microglial cell line (BV2 cells) induced by lipopolysaccharide. Cell proliferation activity was detected by CCK-8 assay.
Sijie Liu +5 more
doaj +1 more source
High-Frequency Ultrasound Imaging to Evaluate Liver Fibrosis Progression in Rats and Yi Guan Jian Herbal Therapeutic Effects [PDF]
, 2013 The animals used in liver fibrosis studies must usually be sacrificed. Ultrasound has been demonstrated to have the ability to diagnose hepatic fibrosis and cirrhosis in experimental small-animal models.
Chia-Hui Chuang +8 more
core +2 more sources
New Zealand Journal of Crop and Horticultural Science, Volume 54, Issue 1, March 2026.This study aimed to investigate the effects of cobalt (Co) and zinc (Zn) on the growth, antioxidant activity, total phenolic and flavonoid contents (TPC and TFC), targeted polyphenolic compounds, and molecular dynamics simulations of Rehmannia glutinosa (R. glutinosa) L.
Bimal Kumar Ghimire +9 more
wiley +1 more source
Effect of catalpol on behavior and neurodevelopment in an ADHD rat model
Biomedicine & Pharmacotherapy, 2019 Studies suggest that abnormal neurodevelopment of prefrontal striatal circuits is implicated in the pathogenesis of attention deficit hyperactivity disorder (ADHD). In the present study, we investigated the effect of catalpol, an active ingredient of Rehmanniae radix preparata, which is the most frequently used Chinese medicinal herb for the treatment ...
Haixia, Yuan +5 more
openaire +2 more sources
Catalpol alleviates amyloid- generation and neuronal oxidative stress injury via activating the Keap1-Nrf2/ARE signaling pathway in the immortalized lymphocytes from patients with late-onset Alzheimer’s disease and SKNMC cells co-culture model [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): To assess the effect of catalpol, the major bioactive constituents of Rehmannia glutinosa, on our Alzheimer’s disease (AD) in vitro model.Materials and Methods: We employed the immortalized lymphocytes (lymphoblastoid cell line, LCL) from ...
Caixia Xiang +5 more
doaj +1 more source
α-Synuclein induced cell death in mouse hippocampal (HT22) cells is mediated by nitric oxide-dependent activation of caspase-3 [PDF]
, 2009 Our previous studies indicated that exogenous α-synuclein (ASN) activates neuronal nitric oxide (NO) synthase (nNOS) in rat brain slices. The present study, carried out on immortalized hippocampal neuronal cells (HT22), was designed to extend the ...
Adamczyk, Agata +3 more
core +1 more source
Journal of Food Processing and Preservation, Volume 2026, Issue 1, 2026.Cistanche deserticola (CD) Y. C. Ma is a well‐known tonic medicinal material, and its clinical value and industrial development are highly dependent on the integrity of core pharmacodynamic components (such as phenylosides and polysaccharides). This article systematically reviews the impact of three key links: harvest maturity, postharvest preservation
Yao Zhang +7 more
wiley +1 more source