Results 61 to 70 of about 1,785 (172)

Multifaceted Roles of Chloroquines in Gastrointestinal Disorders and Beyond

Comprehensive Physiology, Volume 16, Issue 4, August 2026.
Chloroquine (CQ) and hydroxychloroquine (HCQ) modulate lysosomal activity and autophagy, suppressing gastrointestinal inflammation and reshaping pathogenic microbiota. These mechanisms alleviate inflammatory bowel disease, inhibit associated tumor growth, and provide benefits in certain autoimmune and viral conditions.
Sihyun Jeong, Eunsoo Kim, Yong Sung Kim, Eunok Im   +3 more
wiley   +1 more source

Catalpol alleviates amyloid- generation and neuronal oxidative stress injury via activating the Keap1-Nrf2/ARE signaling pathway in the immortalized lymphocytes from patients with late-onset Alzheimer’s disease and SKNMC cells co-culture model [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): To assess the effect of catalpol, the major bioactive constituents of Rehmannia glutinosa, on our Alzheimer’s disease (AD) in vitro model.Materials and Methods: We employed the immortalized lymphocytes (lymphoblastoid cell line, LCL) from ...
Caixia Xiang, Yunwei Lu, Renjuan Hao, Yuyan Wei, Yingchao Hu, Guran Yu   +5 more
doaj   +1 more source

Direct and indirect effects of elevated CO2, warming and drought on plant–consumer interactions of Plantago lanceolata

Journal of Ecology, Volume 114, Issue 8, August 2026.
Experimental treatments of warming, elevated CO2, drought and their interactions had direct and indirect (plant‐trait‐mediated) effects on field Plantago lanceolata consumption and feeding preferences of the locust Locusta migratoria. The effects largely differed between consumption types, despite being studied on the same species in the same system ...
Micha Davidová, Dinesh Thakur, Michael Bahn, Andreas Schaumberger, Nikita Rathore, Jaroslav Semerád, Tomáš Cajthaml, Zuzana Münzbergová   +7 more
wiley   +1 more source

In vitro study on the preparation of catalpol/GelMA hydrogel and its antioxidant properties

Kouqiang hemian waike zazhi
[Objective:] To investigate the effects of catalpol on rat Schwann cell (RSC) and establish a catalpol/methacrylated gelatin (GelMA) hydrogel, followed by in vitro evaluation of its biocompatibility and antioxidant properties.
ZHANG Chunlei, WANG Di, YANG Jing, HAN Hongyang, YANG Shu, PANG Bo, SONG Tao   +6 more
doaj   +1 more source

Dietary Polyphenols as Natural Modulators of NF‐κB Signaling in Inflammation‐Driven Non‐Communicable Diseases: Focus on Cancer

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
Dietary polyphenols and phytochemicals suppress NF‐κB signaling. Mechanistically, by inhibiting IκBα degradation and preventing nuclear translocation of p65/p50 complexes, the polyphenols reduce the expression of pro‐inflammatory and pro‐survival genes, thereby decreasing overall cancer cell survival.
Khuzin Dinislam, Anas Shamsi, Syed Tasqeruddin, Moyad Shahwan   +3 more
wiley   +1 more source

Inhibition of Colorectal Cancer Cell Progression by Picroside II Through Modulation of the Notch1 Signaling Pathway

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 7, July 2026.
Picroside II inhibits colorectal cancer progression by blocking Notch1 signaling activation. It interferes with Notch1 activation by preventing the cleavage and nuclear translocation of the Notch intracellular domain (NICD). Upon ligand binding, Notch1 is cleaved by ADAM and γ‐secretase, releasing NICD, which translocates into the nucleus and forms a ...
Rui Wang, Wei Zhang, Fang Wang, Yong Zhang, Jiayi Li   +4 more
wiley   +1 more source

Protective effects of catalpol on mitochondria of hepatocytes in cholestatic liver injury

Molecular Medicine Reports, 2020
Cholestasis, which is caused by the obstruction of bile flow, can lead to rapid organ injury, cell apoptosis and necrosis of hepatocytes, and may eventually develop into fibrosis and cirrhosis. Oxidative stress and mitochondrial dysfunction are the key pathogenic signs of hepatic cholestasis.
Gao, Xingjuan, Xu, Jiaju, Liu, Hongbo
openaire   +3 more sources

Design, synthesis and anticancer activities evaluation of novel pyrazole modified catalpol derivatives

Scientific Reports, 2023
Catalpol, a natural product mainly existed in plenty of Chinese traditional medicines, is an iridoid compound with the comprehensive effects on neuroprotective, anti-inflammatory, choleretic, hypoglycemic and anticancer.
Yuanfang Kong, Shuanglin Liu, Shaopei Wang, Bin Yang, Wei He, Hehe Li, Siqi Yang, Guoqing Wang, Chunhong Dong   +8 more
doaj   +1 more source

Encephalopathy: Cause, Pathogenesis, and Treatment

MedComm, Volume 7, Issue 6, June 2026.
Various encephalopathies (sepsis‐associated, hepatic, hypoxic–ischemic, diabetic, uremic, toxic) have incompletely elucidated pathogenesis, which severely restricts targeted therapy development. Small molecule drugs show unique multitarget potential but face toxicity, poor blood–brain barrier penetration and unclear specificity.
Shimeng Lv, Xia Zhong, Ruirui Shang, Linghui Kong, Yufei Huang, Yuexiang Ma, Jing Teng, Sheng Wei   +7 more
wiley   +1 more source

The Structure of Carboxyl Methyltransferase Provides Insights Into the Substrate Specificity and Divergent Evolution of Iridoid

Plant Biotechnology Journal, Volume 24, Issue 6, Page 3708-3722, June 2026.
ABSTRACT Iridoids constitute a prominent class of plant‐specialised metabolites, with carbocyclic iridoids (e.g., geniposide) and secoiridoids (e.g., loganin) diverging early in their biosynthetic pathways. This divergence is marked by substrate‐specific carboxyl methyltransferases—GjGAMT and CrLAMT—that catalyse the decisive methylation step in ...
Li Li, Zhiteng Luo, Zhaoyin He, Jie Tang, Wuke Wei, Ruoting Zhan, Huihao Zhou, Dongming Ma   +7 more
wiley   +1 more source