Results 41 to 50 of about 3,043 (217)

Catalpol Protects ARPE-19 Cells against Oxidative Stress via Activation of the Keap1/Nrf2/ARE Pathway

open access: yesCells, 2021
Oxidative damage to retinal pigment epithelial (RPE) has been identified as one of the major regulatory factors in the pathogenesis of age-related macular degeneration (AMD).
Longtai You   +10 more
doaj   +1 more source

Determination of Aucubin and Catalpol in Plantago Species by Micellar Electrokinetic Chromatography [PDF]

open access: yesZeitschrift für Naturforschung C, 2004
Micellar electrokinetic chromatography (MEKC) was used for the separation and determination of two iridoid glycosides, aucubin and catalpol, in several Plantago species growing in Croatia: P. altissima L., P. argentea Chaix, P. coronopus L., P. holosteum Scop. (subsp. depauperata, subsp. holosteum and subsp. scopulorum), P. lagopus L., P. lanceolata L.,
Vladimir-Knežević, Sanda   +3 more
openaire   +4 more sources

Catalpol promotes the osteogenic differentiation of bone marrow mesenchymal stem cells via the Wnt/β-catenin pathway

open access: yesStem Cell Research & Therapy, 2019
Background Rehmanniae Radix is a traditional herbal medicine in East Asia that has been widely used to treat patients with osteoporosis. However, the effect of catalpol, the primary active principle component of Rehmanniae Radix, on the function of bone ...
Yu Zhu   +4 more
doaj   +1 more source

Pharmacokinetic Evaluation of Clozapine in Concomitant Use of Radix Rehmanniae, Fructus Schisandrae, Radix Bupleuri, or Fructus Gardeniae in Rats [PDF]

open access: yes, 2016
: Radix Rehmanniae, Fructus Schisandrae, Radix Bupleuri, and Fructus Gardeniae are often used alongside with clozapine (CLZ) for schizophrenia patients in order to reduce side effects and enhance therapeutic efficacy.
Sze, CWS   +4 more
core   +1 more source

Catalpol Exerts a Neuroprotective Effect in the MPTP Mouse Model of Parkinson’s Disease

open access: yesFrontiers in Aging Neuroscience, 2019
The degeneration of dopaminergic (DA) neurons in Parkinson’s disease (PD) is related to inflammation and oxidative stress. Anti-inflammatory agents could reduce the risk or slow the progression of PD.
Li-Yuan Wang   +6 more
doaj   +1 more source

Plant bioactive molecules bearing glycosides as lead compounds for the treatment of fungal infection: A review [PDF]

open access: yes, 2017
Despite therapeutic advancement in the treatment of fungal infections, morbidity and mortality caused by these infections are still very high. There are approximately 300 fungal species that are infectious and can cause a variety of diseases. At present,
Amin, Surriya   +6 more
core   +1 more source

Omics analyses of Rehmannia glutinosa dedifferentiated and cambial meristematic cells reveal mechanisms of catalpol and indole alkaloid biosynthesis

open access: yesBMC Plant Biology, 2023
Background Rehmannia glutinosa is a rich source of terpenoids with a high medicinal reputation. The present study compared dedifferentiated cells (DDCs) and cambial meristematic cells (CMCs) cell cultures of R.
Pengfei Zhou   +11 more
doaj   +1 more source

Catalpol relieved angiotensin II-induced blood–brain barrier destruction via inhibiting the TLR4 pathway in brain endothelial cells

open access: yesPharmaceutical Biology, 2022
Context Catalpol is a major bioactive constituent of Rehmannia glutinosa Libosch (Scrophulariaceae), a traditional Chinese medicine, which is widely used in multiple diseases, including hypertension.Objectives To explore whether catalpol protects against
Yu Xia   +3 more
doaj   +1 more source

Recent advances in the multifaceted mechanisms of catalpol in treating osteoporosis. [PDF]

open access: yesFront Pharmacol
Catalpol (CAT) is a landmark active ingredient in traditional Chinese medicine Rehmannia (TCT), also known as dehydroxybenzoate catalpone, which is a kind of iridoid terpene glycoside with strong antioxidant, anti-inflammatory, antitumor and other biological activities. It can exert its anti-disease effect in a variety of ways.
Li N, Mu X, Zhang S, Wang H.
europepmc   +4 more sources

A potential therapeutic effect of catalpol in Duchenne muscular dystrophy revealed by binding with TAK1

open access: yesJournal of Cachexia, Sarcopenia and Muscle, 2020
Background Duchenne muscular dystrophy (DMD) is a progressive muscle disease caused by the loss of dystrophin, which results in inflammation, fibrosis, and the inhibition of myoblast differentiation in skeletal muscle.
Dengqiu Xu   +11 more
doaj   +1 more source

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