Results 21 to 30 of about 1,785 (172)

Catalpol promotes the generation of cerebral organoids with oRGs through activation of STAT3 signaling [PDF]

Bioengineering & Translational Medicine
The generation of human cortical organoids containing outer radial glia (oRG) cells is crucial for modeling neocortical development. Here we show that Catalpol, an iridoid glucoside derived from Rehmannia glutinosa, significantly enhances the generation ...
Yoo‐Jung Lee, Byounggook Cho, Daeyeol Kwon, Yunkyung Kim, Saemin An, Soi Kang, Jongpil Kim   +6 more
doaj   +2 more sources

Protection of catalpol against triptolide-induced hepatotoxicity by inhibiting excessive autophagy via the PERK-ATF4-CHOP pathway [PDF]

PeerJ, 2022
Catalpol significantly reduces triptolide-induced hepatotoxicity, which is closely related to autophagy. The aim of this study was to explore the unclear protective mechanism of catalpol against triptolide.
Linluo Zhang, Changqing Li, Ling Fu, Zhichao Yu, Gengrui Xu, Jie Zhou, Meiyu Shen, Zhe Feng, Huaxu Zhu, Tong Xie, Lingling Zhou, Xueping Zhou   +11 more
doaj   +2 more sources

Effect and Mechanism of Catalpol on Remyelination via Regulation of the NOTCH1 Signaling Pathway

Frontiers in Pharmacology, 2021
Promoting the differentiation of oligodendrocyte precursor cells (OPCs) is important for fostering remyelination in multiple sclerosis. Catalpol has the potential to promote remyelination and exert neuroprotective effects, but its specific mechanism is ...
Yaqin Sun, Jing Ji, Zheng Zha, Hui Zhao, Bing Xue, Liangyun Jin, Lei Wang   +6 more
doaj   +1 more source

Research Progress on the Multitarget Mechanisms of Terpenoids in the Treatment of Ischemic Stroke. [PDF]

Stroke Res Treat
Cerebral ischemic stroke (CIS) is an acute cerebrovascular disease associated with high morbidity and disability rates. It is characterized by neurological damage caused by the interruption of cerebral blood flow, often accompanied by sequelae such as motor dysfunction and cognitive decline, which seriously affect the quality of life of patients ...
Yang J, Wang Z, Shi T, Wu S, He P, Han Y, Tian D, Xu S, Lan J, Xi Y, Pan P, Wang J.   +11 more
europepmc   +2 more sources

Effects of Catalpol on Alzheimer’s Disease and Its Mechanisms

Evidence-Based Complementary and Alternative Medicine, 2022
Alzheimer’s disease (AD) is a degenerative disease of the central nervous system characterized by memory loss and cognitive dysfunction. With the increasing aging of the population, the incidence of AD and the number of patients are also increasing year by year, causing more and more heavy burdens to the family and society.
Huize Chen, Chujun Deng, Zeyu Meng, Shengxi Meng   +3 more
openaire   +3 more sources

Catalpol Inhibits Macrophage Polarization and Prevents Postmenopausal Atherosclerosis Through Regulating Estrogen Receptor Alpha

Frontiers in Pharmacology, 2021
Lacking estrogen increases the risk of atherosclerosis (AS) in postmenopausal women. Inflammation plays a vital role in the pathological process of AS, and macrophages are closely related to inflammation.
Qi Chen, Xu Qi, Weiwei Zhang, Yuhan Zhang, Yunhui Bi, Qinghai Meng, Huimin Bian, Huimin Bian, Yu Li   +8 more
doaj   +1 more source

Catalpol Protects Against High Glucose-Induced Bone Loss by Regulating Osteoblast Function

Frontiers in Pharmacology, 2021
Objective: The overall objective of this study was to investigate the effects of catalpol on bone remodeling of diabetic osteoporosis by regulating osteoblast differentiation and migration.Method: Using a murine model of diabetic osteoporosis, to detect ...
Lu Zhao, Wei Du, Dandan Zhao, Xueyan Ji, Yanfei Huang, Yong Pang, Kaijin Guo, Xiaoxing Yin   +7 more
doaj   +1 more source

<i>Rehmannia glutinosa</i> Extracts Enhances Ketone Bodies Expression and Alleviates Ulcerative Colitis as A Novel Ketogenic Functional Food. [PDF]

Food Sci Nutr
Rehmannia glutinosa (DH) can act as a novel ketogenic functional food to enhance the expression of ketone bodies without altering the normal dietary structure. This effect might be attributed to the increased activity of key enzymes involved in ketogenesis, such as 3‐hydroxybutyrate dehydrogenase 1 (BDH1) and 3‐hydroxymethylglutaryl‐CoA synthase 2 ...
Gao Y, Wang S, Yang Y, Tang W, Zhen J, Song X.   +5 more
europepmc   +2 more sources

Catalpol ameliorates CFA-induced inflammatory pain by targeting spinal cord and peripheral inflammation

Frontiers in Pharmacology, 2022
Chronic, inflammatory pain is an international health concern that severely diminishes individuals’ quality of life. Catalpol is an iridoid glycoside derived from the roots of Rehmannia glutinosa that possesses anti-inflammatory, antioxidant, and ...
Baoxia Zhao, Baoxia Zhao, Jie Fu, Jie Fu, Huadong Ni, Longsheng Xu, Chengfei Xu, Qiuli He, Chaobo Ni, Yahui Wang, Jiao Kuang, Mengjie Tang, Qiyang Shou, Ming Yao, Ming Yao   +14 more
doaj   +1 more source

Analyses of Transcriptomics upon IL-1β-Stimulated Mouse Chondrocytes and the Protective Effect of Catalpol through the NOD2/NF-κB/MAPK Signaling Pathway

Molecules, 2023
The overall objective of this study was to investigate the mechanism of inflammation on chondrocyte injury and the protective effect of catalpol on chondrocytes in an inflammatory environment.
Yong Pang, Lu Zhao, Xueyan Ji, Kaijin Guo, Xiaoxing Yin   +4 more
doaj   +1 more source