Results 21 to 30 of about 3,043 (217)

Analyses of Transcriptomics upon IL-1β-Stimulated Mouse Chondrocytes and the Protective Effect of Catalpol through the NOD2/NF-κB/MAPK Signaling Pathway

Molecules, 2023
The overall objective of this study was to investigate the mechanism of inflammation on chondrocyte injury and the protective effect of catalpol on chondrocytes in an inflammatory environment.
Yong Pang, Lu Zhao, Xueyan Ji, Kaijin Guo, Xiaoxing Yin   +4 more
doaj   +1 more source

Catalpol ameliorates CFA-induced inflammatory pain by targeting spinal cord and peripheral inflammation

Frontiers in Pharmacology, 2022
Chronic, inflammatory pain is an international health concern that severely diminishes individuals’ quality of life. Catalpol is an iridoid glycoside derived from the roots of Rehmannia glutinosa that possesses anti-inflammatory, antioxidant, and ...
Baoxia Zhao, Baoxia Zhao, Jie Fu, Jie Fu, Huadong Ni, Longsheng Xu, Chengfei Xu, Qiuli He, Chaobo Ni, Yahui Wang, Jiao Kuang, Mengjie Tang, Qiyang Shou, Ming Yao, Ming Yao   +14 more
doaj   +1 more source

Iridoids and other Mmnoterpenes in the Alzheimer’s Brain: Recent development and future prospects [PDF]

, 2018
Iridoids are a class of monoterpenoid compounds constructed from 10-carbon skeleton of isoprene building units. These compounds in their aglycones and glycosylated forms exist in nature to contribute to mechanisms related to plant defenses and diverse ...
Habtemariam, Habtemariam, Habtemariam, Juan-Badaturugea, Liu, Llusià, Solomon Habtemariam, Vekrellis, Wagner, Wang, Wang, Zhong   +11 more
core   +5 more sources

The Salutary Effects of Catalpol on Diesel Exhaust Particles-Induced Thrombogenic Changes and Cardiac Oxidative Stress, Inflammation and Apoptosis

Biomedicines, 2022
Inhaled particulate air pollution exerts pulmonary inflammation and cardiovascular toxicity through secondary systemic effects due to oxidative stress and inflammation.
Abderrahim Nemmar, Sumaya Beegam, Nur Elena Zaaba, Salem Alblooshi, Saleh Alseiari, Badreldin H. Ali   +5 more
doaj   +1 more source

Catalpol Modulates Lifespan via DAF-16/FOXO and SKN-1/Nrf2 Activation in [PDF]

, 2015
Catalpol is an effective component of rehmannia root and known to possess various pharmacological properties. The present study was aimed at investigating the potential effects of catalpol on the lifespan and stress tolerance using C.
Cha, Dong Seok, Cheon, Se Myung, Jeon, Hoon, Kim, Hong Jun, Lee, Myon-Hee, NC DOCKS at East Carolina University, Seo, Hyun Won   +6 more
core   +4 more sources

Anti-Apoptotic Effects of Catalpol on Preimplantaion Porcine Embryos

Journal of Animal Reproduction and Biotechnology, 2015
Catalpol, an iridoid glucoside, isolated from the root of Rehmannia glutinosa Libosch. It possesses a broad range of biological and pharmacological activity including anti-tumor, anti-inflammation and anti-oxidant by acting as a free radical scavenger ...
Yong-Hee Lee, Jin-Woo Kim, Sung-Kyu Chae, Jae-Hyun Ahn, Geon-Yeop Do, Deog-Bon Koo   +5 more
doaj   +1 more source

Unusual iridoid glycosides in Veronica sects. Hebe and Labiatoides [PDF]

, 2008
In a chemosystematic investigation of three Southern hemisphere species of Veronica, namely the Australian V. derwentiana Andrews and V. perfoliata R.Br. (formerly Derwentia species), and the New Zealand V. catarractae G.
Jensen, Søren Rosendal
core   +1 more source

Multiple Biological Effects of an Iridoid Glucoside, Catalpol, and Its Underlying Molecular Mechanisms

Biomolecules, 2019
Catalpol, an iridoid glucoside, is widely distributed in many plant families and is primarily obtained from the root of Rehmannia glutinosa Libosch. Rehmannia glutinosa is a plant very commonly used in Chinese and Korean traditional medicine for various ...
Subrat Kumar Bhattamisra, Kah Heng Yap, Vikram Rao, Hira Choudhury   +3 more
doaj   +1 more source

Medicinal Plants with Multiple Effects on Diabetes Mellitus and Its Complications: a Systematic Review [PDF]

, 2018
Purpose of Review This systematic review describes evidence concerning medicinal plants that, in addition to exerting hypoglycemic effects, decrease accompanying complications such as nephropathy, neuropathy, retinopathy, hypertension, and/or ...
Lorigooini, Zahra., Nazarian-Samani, Zeinab., Rafieian-Kopaei, Mahmoud., Sewell, Robert.D.E.   +3 more
core   +6 more sources

Catalpol Inhibits Amyloid-β Generation Through Promoting α-Cleavage of APP in Swedish Mutant APP Overexpressed N2a Cells

Frontiers in Aging Neuroscience, 2018
Amyloid-β (Aβ) peptides play a crucial role in the pathogenesis of Alzheimer’s disease (AD), due to its neurotoxicity. Thus, blocking Aβ generation and aggregation in the brain has been realized as an efficient way for the prevention of AD.
Zhuo Wang, Xueshi Huang, Pu Zhao, Limei Zhao, Zhan-You Wang, Zhan-You Wang   +5 more
doaj   +1 more source