Catalpol inhibits HHcy-induced EndMT in endothelial cells by modulating ROS/NF-κB signaling [PDF]
BMC Cardiovascular DisordersBackground Hyperhomocysteinemia (HHcy) is an independent risk factor for atherosclerosis (AS). Endothelial mesenchymal transition (EndMT) refers to the process in which endothelial cells lose endothelial cell morphology and characteristic gene expression,
Chengyan Wu +4 more
doaj +2 more sources
Catalpol in Diabetes and its Complications: A Review of Pharmacology, Pharmacokinetics, and Safety [PDF]
Molecules, 2019 This review aimed to provide a general view of catalpol in protection against diabetes and diabetic complications, as well as its pharmacokinetics and safety concerns.
Ying Bai +10 more
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Research Progress on Catalpol as Treatment for Atherosclerosis [PDF]
Frontiers in Pharmacology, 2021 Coronary atherosclerotic heart disease, cerebrovascular disease, and peripheral artery disease are common diseases with high morbidity and mortality rates and must be addressed. Their most frequent complications, including myocardial infarction and stroke, are caused by spontaneous thrombotic occlusion and are the most frequent cause of death worldwide.
Lei He +5 more
openaire +3 more sources
The Mechanism of Catalpol to Improve Oxidative Damage of Dermal Fibroblasts Based on Nrf2/HO-1 Signaling Pathway [PDF]
Drug Design, Development and TherapyXiaona Lang,1 Liyan Xu,2 Lu Li,1 Xin Feng1 1Pharmacy Department, Tianjin Hospital, Tianjin, People’s Republic of China; 2Orthopedic Department, Tianjin Hospital, Tianjin, People’s Republic of ChinaCorrespondence: Xin Feng, Pharmacy Department, Tianjin ...
Lang X, Xu L, Li L, Feng X
doaj +2 more sources
Catalpol: An Iridoid Glycoside With Potential in Combating Cancer Development and Progression-A Comprehensive Review. [PDF]
Phytother ResCatalpol's potential in inhibiting cancer development and progression through various pathways. ABSTRACT Catalpol, a natural iridoid glycoside known for its anti‐proliferative effects, has been proposed as an anticancer compound. Catalpol targets critical processes involved in cancer cell progression, like malignant proliferation, apoptosis, and ...
Laurindo LF +13 more
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Effects of Catalpol on Alzheimer’s Disease and Its Mechanisms
Evidence-Based Complementary and Alternative Medicine, 2022 Alzheimer’s disease (AD) is a degenerative disease of the central nervous system characterized by memory loss and cognitive dysfunction. With the increasing aging of the population, the incidence of AD and the number of patients are also increasing year by year, causing more and more heavy burdens to the family and society.
Huize Chen +3 more
openaire +3 more sources
Protection of catalpol against triptolide-induced hepatotoxicity by inhibiting excessive autophagy via the PERK-ATF4-CHOP pathway [PDF]
PeerJ, 2022 Catalpol significantly reduces triptolide-induced hepatotoxicity, which is closely related to autophagy. The aim of this study was to explore the unclear protective mechanism of catalpol against triptolide.
Linluo Zhang +11 more
doaj +2 more sources
Effect and Mechanism of Catalpol on Remyelination via Regulation of the NOTCH1 Signaling Pathway
Frontiers in Pharmacology, 2021 Promoting the differentiation of oligodendrocyte precursor cells (OPCs) is important for fostering remyelination in multiple sclerosis. Catalpol has the potential to promote remyelination and exert neuroprotective effects, but its specific mechanism is ...
Yaqin Sun +6 more
doaj +1 more source
Frontiers in Pharmacology, 2021 Lacking estrogen increases the risk of atherosclerosis (AS) in postmenopausal women. Inflammation plays a vital role in the pathological process of AS, and macrophages are closely related to inflammation.
Qi Chen +8 more
doaj +1 more source
Catalpol Protects Against High Glucose-Induced Bone Loss by Regulating Osteoblast Function
Frontiers in Pharmacology, 2021 Objective: The overall objective of this study was to investigate the effects of catalpol on bone remodeling of diabetic osteoporosis by regulating osteoblast differentiation and migration.Method: Using a murine model of diabetic osteoporosis, to detect ...
Lu Zhao +7 more
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