Catalpol: an natural multifunctional iridoid glycoside with promising therapeutic properties [PDF]
Frontiers in Molecular BiosciencesCatalpol, an iridoid glycoside predominantly derived from the fresh or dried root tuber of Rehmannia glutinosa Libosch (a member of the Scrophulariaceae family), it is a representative compound with the highest content in Rehmannia glutinosa Libosch, and
Guannan He +6 more
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Biomolecules, 2021 Catalpol isolated from Rehmannia glutinosa is a potent antioxidant and investigated against many disorders. This review appraises the key molecular pathways of catalpol against diabetes mellitus and its complications.
Subrat Kumar Bhattamisra +2 more
exaly +3 more sources
Catalpol—a compound from Rehmannia glutinosa can improve hyperlipidemia by modulating gut microbiota and endogenous metabolic pathways [PDF]
Frontiers in MicrobiologyIntroductionCatalpol, an iridoid glycoside derived from Rehmannia glutinosa, is widely recognized for its ability to reduce blood glucose levels. However, its potential therapeutic effects on hyperlipidemia (HL) have yet to be investigated.MethodsTo ...
Xinfeng Pei +5 more
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The impact of catalpol on osteogenic differentiation of the jaw bone marrow mesenchymal stem cells on the basis of network pharmacology, molecular docking and experimental validation [PDF]
BMC Oral HealthObjective The research aims to explore the effects of catalpol on the osteogenic differentiation of Jaw Bone Marrow Mesenchymal Stem Cells(JBMMSCs). Methods The study employed network pharmacology, molecular docking, and in vitro experiments.Potential ...
Rongsui Tang +7 more
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Catalpol ameliorates diabetic retinal vascular endothelial injury by suppressing NLRP3 inflammasome via targeting METTL3-m6A modification [PDF]
International Journal of OphthalmologyAIM: To investigate whether catalpol protects against diabetic retinal vascular endothelial injury by targeting the methyltransferase-like 3 (METTL3)-m6A-thioredoxin-interacting protein (TXNIP) axis and inhibiting nucleotide-binding oligomerization ...
Jing-Yu Liu +5 more
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Role of Dietary Catalpol Supplementation in Regulating Reproductive Development of Harmonia axyridis [PDF]
InsectsThe mass rearing of natural enemy insects is a cornerstone of effective green pest control, making the development of optimized artificial diets critical for sustaining large populations.
Keting Zhao +8 more
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Inhibition of Heat Shock Protein 90β by Catalpol: A Potential Therapeutic Approach for Alleviating Inflammation‐Induced Cartilage Injuries in Osteoarthritis [PDF]
Advanced ScienceOsteoarthritis (OA) is a degenerative joint disease characterized by the metabolic dysfunction of chondrocytes. A promising therapeutic strategy for OA involves suppressing the catabolism of the chondrocyte and promoting its anabolism to restore joint ...
Zhenwei Zhou +14 more
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Catalpol in Diabetes and its Complications: A Review of Pharmacology, Pharmacokinetics, and Safety [PDF]
Molecules, 2019 This review aimed to provide a general view of catalpol in protection against diabetes and diabetic complications, as well as its pharmacokinetics and safety concerns.
Ying Bai +10 more
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Catalpol regulates apoptosis and proliferation of endothelial cell via activating HIF-1α/VEGF signaling pathway [PDF]
Scientific ReportsBurn injuries, especially severe ones, causes microcirculation disorders in local wounds and distant tissues, leading to ischemia and hypoxia of body tissues and organs.
Jinrong Ni +5 more
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Research Progress on Catalpol as Treatment for Atherosclerosis [PDF]
Frontiers in Pharmacology, 2021 Coronary atherosclerotic heart disease, cerebrovascular disease, and peripheral artery disease are common diseases with high morbidity and mortality rates and must be addressed. Their most frequent complications, including myocardial infarction and stroke, are caused by spontaneous thrombotic occlusion and are the most frequent cause of death worldwide.
Lei He +5 more
openaire +3 more sources