Results 31 to 40 of about 1,785 (172)

The Salutary Effects of Catalpol on Diesel Exhaust Particles-Induced Thrombogenic Changes and Cardiac Oxidative Stress, Inflammation and Apoptosis

Biomedicines, 2022
Inhaled particulate air pollution exerts pulmonary inflammation and cardiovascular toxicity through secondary systemic effects due to oxidative stress and inflammation.
Abderrahim Nemmar, Sumaya Beegam, Nur Elena Zaaba, Salem Alblooshi, Saleh Alseiari, Badreldin H. Ali   +5 more
doaj   +1 more source

Catalpol Ameliorates Podocyte Injury by Stabilizing Cytoskeleton and Enhancing Autophagy in Diabetic Nephropathy

Frontiers in Pharmacology, 2019
Catalpol, an iridoid glycoside extracted from Rehmannia glutinosa, has been found to ameliorate diabetic nephropathy (DN), but the mechanism has not been clarified. Podocyte injury play a key role in the pathogenesis of DN. This study mainly investigated
Yan Chen, Qingpu Liu, Zengfu Shan, Wangyang Mi, Yingying Zhao, Meng Li, Baiyan Wang, Xiaoke Zheng, Xiaoke Zheng, Weisheng Feng, Weisheng Feng   +10 more
doaj   +1 more source

Anti-Apoptotic Effects of Catalpol on Preimplantaion Porcine Embryos

Journal of Animal Reproduction and Biotechnology, 2015
Catalpol, an iridoid glucoside, isolated from the root of Rehmannia glutinosa Libosch. It possesses a broad range of biological and pharmacological activity including anti-tumor, anti-inflammation and anti-oxidant by acting as a free radical scavenger ...
Yong-Hee Lee, Jin-Woo Kim, Sung-Kyu Chae, Jae-Hyun Ahn, Geon-Yeop Do, Deog-Bon Koo   +5 more
doaj   +1 more source

Multiple Biological Effects of an Iridoid Glucoside, Catalpol, and Its Underlying Molecular Mechanisms

Biomolecules, 2019
Catalpol, an iridoid glucoside, is widely distributed in many plant families and is primarily obtained from the root of Rehmannia glutinosa Libosch. Rehmannia glutinosa is a plant very commonly used in Chinese and Korean traditional medicine for various ...
Subrat Kumar Bhattamisra, Kah Heng Yap, Vikram Rao, Hira Choudhury   +3 more
doaj   +1 more source

Catalpol Inhibits Amyloid-β Generation Through Promoting α-Cleavage of APP in Swedish Mutant APP Overexpressed N2a Cells

Frontiers in Aging Neuroscience, 2018
Amyloid-β (Aβ) peptides play a crucial role in the pathogenesis of Alzheimer’s disease (AD), due to its neurotoxicity. Thus, blocking Aβ generation and aggregation in the brain has been realized as an efficient way for the prevention of AD.
Zhuo Wang, Xueshi Huang, Pu Zhao, Limei Zhao, Zhan-You Wang, Zhan-You Wang   +5 more
doaj   +1 more source

Beneficial Effects of Catalpol Supplementation during In Vitro Maturation of Porcine Cumulus-Oocyte Complexes

Antioxidants, 2023
Oxidative stress degrades oocytes during in vitro maturation (IVM). Catalpol, a well-known iridoid glycoside, exhibits antioxidant, anti-inflammatory, and antihyperglycemic effects. In this study, catalpol supplementation was tested on porcine oocyte IVM
Yanxin Wang, Ye Xu, Sijia Li, Xi Yan, Xiaofen Yang, Mengjia Chen, Yun Wang, Ruru Jia, Dongping Zhou, Deshun Shi, Fenghua Lu   +10 more
doaj   +1 more source

Enhancement of antiproliferative activity by molecular simplification of catalpol

Bioorganic & Medicinal Chemistry, 2010
Two iridoid scaffolds were synthesized enantioselectively using as key step an l-proline-catalyzed alpha-formyl oxidation. The in vitro antiproliferative activities were evaluated against a representative panel of human solid tumor cell lines. Both iridoids induced considerably growth inhibition in the range 0.38-1.86muM.
García, Celina, León, Leticia G., Pungitore, Carlos Rodolfo, Ríos Luci, Carla, Daranas, Antonio H., Montero, Juan C., Pandiella, Atanasio, Tonn, Carlos Eugenio, Martín, Víctor S., Padrón, José M.   +9 more
openaire   +4 more sources

Antiangiogenic effects of catalpol on rat corneal�neovascularization

Molecular Medicine Reports, 2017
To investigate the effects of catalpol on corneal neovascularization (CNV) and associated inflammation, eye drops (5 mM catalpol or PBS) were administered four times daily to alkali‑burn rat models of CNV and inflammation. Clinical evaluations of CNV and the degree of inflammation were performed on days 0, 4, 7, 10 and 14 under slit lamp microscopy ...
Han, Yun, Shen, Mei, Tang, Li-Yuan, Tan, Gang, Yang, Qi-Chen, Ye, Lei, Ye, Lin-Hong, Jiang, Nan, Gao, Gui-Ping, Shao, Yi   +9 more
openaire   +3 more sources

Feasibility of Catalpol Intranasal Administration and Its Protective Effect on Acute Cerebral Ischemia in Rats via Anti-Oxidative and Anti-Apoptotic Mechanisms

Drug Design, Development and Therapy, 2022
Jinghui Wang,1 Yuhua Zhang,2 Meifeng Zhang,1 Si Sun,1 Yang Zhong,1 Lei Han,1 Yitong Xu,1 Dong Wan,3 Junhui Zhang,4 Huifeng Zhu1 1College of Pharmaceutical Sciences & College of Chinese Medicine, Southwest University, Chongqing, 400715, People’s Republic ...
Wang J, Zhang Y, Zhang M, Sun S, Zhong Y, Han L, Xu Y, Wan D, Zhang J, Zhu H   +9 more
doaj  

Catalpol promotes the osteogenic differentiation of bone marrow mesenchymal stem cells via the Wnt/β-catenin pathway

Stem Cell Research & Therapy, 2019
Background Rehmanniae Radix is a traditional herbal medicine in East Asia that has been widely used to treat patients with osteoporosis. However, the effect of catalpol, the primary active principle component of Rehmanniae Radix, on the function of bone ...
Yu Zhu, Yanmao Wang, Yachao Jia, Jia Xu, Yimin Chai   +4 more
doaj   +1 more source