Biomolecules, 2021 Catalpol isolated from Rehmannia glutinosa is a potent antioxidant and investigated against many disorders. This review appraises the key molecular pathways of catalpol against diabetes mellitus and its complications.
Subrat Kumar Bhattamisra +2 more
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Catalpol—a compound from Rehmannia glutinosa can improve hyperlipidemia by modulating gut microbiota and endogenous metabolic pathways [PDF]
Frontiers in MicrobiologyIntroductionCatalpol, an iridoid glycoside derived from Rehmannia glutinosa, is widely recognized for its ability to reduce blood glucose levels. However, its potential therapeutic effects on hyperlipidemia (HL) have yet to be investigated.MethodsTo ...
Xinfeng Pei +5 more
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The impact of catalpol on osteogenic differentiation of the jaw bone marrow mesenchymal stem cells on the basis of network pharmacology, molecular docking and experimental validation [PDF]
BMC Oral HealthObjective The research aims to explore the effects of catalpol on the osteogenic differentiation of Jaw Bone Marrow Mesenchymal Stem Cells(JBMMSCs). Methods The study employed network pharmacology, molecular docking, and in vitro experiments.Potential ...
Rongsui Tang +7 more
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Frontiers in Pharmacology, 2019 Catalpol, an iridoid glycoside extracted from Rehmannia glutinosa, has been found to ameliorate diabetic nephropathy (DN), but the mechanism has not been clarified. Podocyte injury play a key role in the pathogenesis of DN. This study mainly investigated
Meng Li, Baiyan Wang, Xiaoke Zheng
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Catalpol: an natural multifunctional iridoid glycoside with promising therapeutic properties [PDF]
Frontiers in Molecular BiosciencesCatalpol, an iridoid glycoside predominantly derived from the fresh or dried root tuber of Rehmannia glutinosa Libosch (a member of the Scrophulariaceae family), it is a representative compound with the highest content in Rehmannia glutinosa Libosch, and
Guannan He +6 more
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Inhibition of Heat Shock Protein 90β by Catalpol: A Potential Therapeutic Approach for Alleviating Inflammation‐Induced Cartilage Injuries in Osteoarthritis [PDF]
Advanced ScienceOsteoarthritis (OA) is a degenerative joint disease characterized by the metabolic dysfunction of chondrocytes. A promising therapeutic strategy for OA involves suppressing the catabolism of the chondrocyte and promoting its anabolism to restore joint ...
Zhenwei Zhou +14 more
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Role of Dietary Catalpol Supplementation in Regulating Reproductive Development of Harmonia axyridis [PDF]
InsectsThe mass rearing of natural enemy insects is a cornerstone of effective green pest control, making the development of optimized artificial diets critical for sustaining large populations.
Keting Zhao +8 more
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Catalpol regulates apoptosis and proliferation of endothelial cell via activating HIF-1α/VEGF signaling pathway [PDF]
Scientific ReportsBurn injuries, especially severe ones, causes microcirculation disorders in local wounds and distant tissues, leading to ischemia and hypoxia of body tissues and organs.
Jinrong Ni +5 more
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Catalpol reduced LPS induced BV2 immunoreactivity through NF-κB/NLRP3 pathways: an in Vitro and in silico study [PDF]
Frontiers in PharmacologyBackground: Ischemic Stroke (IS) stands as one of the primary cerebrovascular diseases profoundly linked with inflammation. In the context of neuroinflammation, an excessive activation of microglia has been observed.
Yong She +5 more
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Catalpol promotes the generation of cerebral organoids with oRGs through activation of STAT3 signaling [PDF]
Bioengineering & Translational MedicineThe generation of human cortical organoids containing outer radial glia (oRG) cells is crucial for modeling neocortical development. Here we show that Catalpol, an iridoid glucoside derived from Rehmannia glutinosa, significantly enhances the generation ...
Yoo‐Jung Lee +6 more
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