Results 31 to 40 of about 4,561,775 (254)
Modulation of catalytic activity in multi-domain protein tyrosine phosphatases. [PDF]
PLoS ONE, 2011 Signaling mechanisms involving protein tyrosine phosphatases govern several cellular and developmental processes. These enzymes are regulated by several mechanisms which include variation in the catalytic turnover rate based on redox stimuli, subcellular
Lalima L Madan +5 more
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Catalytic Domain Architecture of Metzincin Metalloproteases [PDF]
Journal of Biological Chemistry, 2009 Metalloproteases cleave proteins and peptides, and deregulation of their function leads to pathology. An understanding of their structure and mechanisms of action is necessary to the development of strategies for their regulation. Among metallopeptidases are the metzincins, which are mostly multidomain proteins with approximately 130-260-residue ...
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Scientific Reports, 2017 The polymixin colistin is a “last line” antibiotic against extensively-resistant Gram-negative bacteria. Recently, the mcr-1 gene was identified as a plasmid-mediated resistance mechanism in human and animal Enterobacteriaceae, with a wide geographical ...
P. Hinchliffe +20 more
semanticscholar +1 more source
Hybrid and rogue kinases encoded in the genomes of model eukaryotes. [PDF]
PLoS ONE, 2014 The highly modular nature of protein kinases generates diverse functional roles mediated by evolutionary events such as domain recombination, insertion and deletion of domains.
Ramaswamy Rakshambikai +2 more
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Tetrameric Structure of a Serine Integrase Catalytic Domain [PDF]
Structure, 2008 The serine integrases have recently emerged as powerful new chromosome engineering tools in various organisms and show promise for therapeutic use in human cells. The serine integrases are structurally and mechanistically unrelated to the bacteriophage lambda integrase but share a similar catalytic domain with the resolvase/invertase enzymes typified ...
Yuan, Peng +2 more
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Essential role of the C-terminal helical domain in active site formation of selenoprotein MsrA from Clostridium oremlandii. [PDF]
PLoS ONE, 2015 We previously determined the crystal structures of 1-Cys type selenoprotein MsrA from Clostridium oremlandii (CoMsrA). The overall structure of CoMsrA is unusual, consisting of two domains, the N-terminal catalytic domain and the C-terminal distinct ...
Eun Hye Lee +3 more
doaj +1 more source
The Bacillus subtilis signaling protein SpoIVB defines a new family of serine peptidases [PDF]
, 2002 The protein SpoIVB plays a key role in signaling in the sigma (K) checkpoint of Bacillus subtilis. This regulatory mechanism coordinates late gene expression during development in this organism and we have recently shown SpoIVB to be a serine peptidase ...
Brannigan, J A, Cutting, S M, Hoa, N T
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Targeted DNA demethylation of the Arabidopsis genome using the human TET1 catalytic domain
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance DNA methylation is an epigenetic modification involved in gene silencing. Studies of this modification usually rely on the use of mutants or chemicals that affect methylation maintenance.
Javier Gallego-Bartolomé +8 more
semanticscholar +1 more source
The chitinase C gene PsChiC from Pseudomonas sp. and its synergistic effects on larvicidal activity
Genetics and Molecular Biology, 2015 Pseudomonas sp. strain TXG6-1, a chitinolytic gram-negative bacterium, was isolated from a vegetable field in Taixing city, Jiangsu Province, China. In this study, a Pseudomonas chitinase C gene (PsChiC) was isolated from the chromosomal DNA of this ...
Wanfang Zhong, Shaojun Ding, Huifang Guo
doaj +1 more source
eLife, 2022 Mycobacterium tuberculosis adenylyl cyclase (AC) Rv1625c/Cya is an evolutionary ancestor of the mammalian membrane ACs and a model system for studies of their structure and function.
Ved Mehta +9 more
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