Results 41 to 50 of about 4,561,775 (254)
Crystal structure of the catalytic domain of HIV-1 restriction factor APOBEC3G in complex with ssDNA
Nature Communications, 2018 The human APOBEC3G protein is a cytidine deaminase that generates cytidine to deoxy-uridine mutations in single-stranded DNA (ssDNA), and capable of restricting replication of HIV-1 by generating mutations in viral genome. The mechanism by which APOBEC3G
A. Maiti +7 more
semanticscholar +1 more source
ACS Central Science, 2018 Mucin-type O-glycosylation is initiated by a family of polypeptide GalNAc-transferases (GalNAc-Ts) which are type-II transmembrane proteins that contain Golgi luminal catalytic and lectin domains that are connected by a flexible linker. Several GalNAc-Ts,
M. de las Rivas +14 more
semanticscholar +1 more source
Two Catalytic Domains Are Required for Protein Deacetylation [PDF]
Journal of Biological Chemistry, 2006 Histone deacetylase (HDAC)-6 was recently identified as a dual substrate, possibly multisubstrate, deacetylase that can act both on acetylated histone tails and on alpha-tubulin acetylated on Lys40. HDAC-6 is unique among deacetylases in having two hdac domains, and we have used this enzyme as a useful model to dissect the structural requirements for ...
Zhang, Yu +3 more
openaire +3 more sources
Structure- and context-based analysis of the GxGYxYP family reveals a new putative class of glycoside hydrolase. [PDF]
, 2014 BackgroundGut microbiome metagenomics has revealed many protein families and domains found largely or exclusively in that environment. Proteins containing the GxGYxYP domain are over-represented in the gut microbiota, and are found in Polysaccharide ...
Chang, Yuanyuan +5 more
core +2 more sources
Structural rearrangement of CaMKIIα catalytic domains encodes activation [PDF]
Proceedings of the National Academy of Sciences, 2009 At its fundamental level, human memory is thought to occur at individual synaptic contact sites and manifest as persistent changes in synaptic efficacy. In digital electronics, the fundamental structure for implementing memory is the flip-flop switch, a circuit that can be triggered to flip between two stable states.
Christopher, Thaler +4 more
openaire +2 more sources
Controlling tetramer formation, subunit rotation and DNA ligation during Hin-catalyzed DNA inversion. [PDF]
, 2015 Two critical steps controlling serine recombinase activity are the remodeling of dimers into the chemically active synaptic tetramer and the regulation of subunit rotation during DNA exchange.
Chang, Yong, Johnson, Reid C
core +3 more sources
Molecules, 2021 Commensal bacterium Clostridium paraputrificum J4 produces several extracellular chitinolytic enzymes including a 62 kDa chitinase Chit62J4 active toward 4-nitrophenyl N,N′-diacetyl-β-d-chitobioside (pNGG).
Jan Dohnálek +7 more
doaj +1 more source
A Catalytic Domain of Eukaryotic DNA Topoisomerase I [PDF]
Journal of Biological Chemistry, 1998 Eukaryotic type IB topoisomerases catalyze the cleavage and rejoining of DNA strands through a DNA-(3'-phosphotyrosyl)-enzyme intermediate. The 314-amino acid vaccinia topoisomerase is the smallest member of this family and is distinguished from its cellular counterparts by its specificity for cleavage at the target sequence 5'-CCCTT downward arrow ...
C, Cheng, S, Shuman
openaire +2 more sources
Mutational analysis of a ras catalytic domain. [PDF]
Molecular and Cellular Biology, 1986 We used linker insertion-deletion mutagenesis to study the catalytic domain of the Harvey murine sarcoma virus v-rasH transforming protein, which is closely related to the cellular rasH protein. The mutants displayed a wide range of in vitro biological activity, from those that induced focal transformation of NIH 3T3 cells with approximately the same ...
Willumsen, B M +7 more
openaire +2 more sources
Biochemical and structural analysis of a site directed mutant of manganese dependent aminopeptidase P from Streptomyces lavendulae [PDF]
Journal of BioScience and Biotechnology, 2015 Aminopeptidase P (APP) removes N-terminal amino acids from peptides and proteins when the penultimate residue is proline. To understand the structure-function relationships of aminopeptidase P of Streptomyces lavendulae, a conserved arginine residue was ...
ARYA NANDAN, KESAVAN M. NAMPOOTHIRI
doaj