Results 61 to 70 of about 9,873 (264)

Polysomnographic Assessment of Sleep Comorbidities in Drug-Naïve Narcolepsy-Spectrum Disorders--A Japanese Cross-Sectional Study. [PDF]

open access: yesPLoS ONE, 2015
This is a large cross-sectional study which aimed to investigate comorbidity rate, degree of sleep-related breathing disorder, polysomnigraphically diagnosible rapid eye movement sleep behavior disorder/rapid eye movement sleep without atonia and ...
Taeko Sasai-Sakuma   +2 more
doaj   +1 more source

Pharmacologic Treatment of Kleine–Levin Syndrome: A Case Report and Comprehensive Review of Therapeutic Options

open access: yesNeuropsychopharmacology Reports, Volume 46, Issue 1, March 2026.
A 12‐year‐old girl with Klein‐Levin syndrome showed central hypopneas and REM sleep without atonia on 24‐h polysomnography, which normalized after clarithromycin treatment alongside clinical remission. ABSTRACT Kleine–Levin syndrome (KLS) is a rare disorder with limited literature on treatment options and efficacy, especially in adolescents.
Sarisa Thawongit   +2 more
wiley   +1 more source

Post-H1N1 Narcolepsy-Cataplexy [PDF]

open access: yesSleep, 2010
NARCOLEPSY-CATAPLEXY, A DISEASE CAUSED BY THE LOSS OF ∼70,000 HYPOCRETIN CELLS IN THE HYPOTHALAMUS AFFECTS ∼20 PER 100,000 INDIVIDUALS, with an incidence of ∼ 0.3–0.6 per 100,000 person-years.1,2 Onset is most typically in the teens, and cases with onset before age 6 or after 40 are rare in Western Europe and North America.3 The disease is extremely ...
Yves, Dauvilliers   +14 more
openaire   +2 more sources

Microbial‐Immune Interplay in CNS Autoimmune Diseases: Lessons from Animal Models and Clinical Studies

open access: yesEuropean Journal of Immunology, Volume 56, Issue 2, February 2026.
Mechanism of action of the intestinal microbiota on CNS autoimmune diseases. Environmental factors shape gut microbiota composition; dysbiosis alters microbial metabolites and antigenic signals. These modulate innate and adaptive immunity, affect barrier integrity, and influence CNS‐resident cells such as microglia and astrocytes, contributing to ...
Matteo Ceccon, Francesca Ronchi
wiley   +1 more source

The functional role of dreaming in emotional processes [PDF]

open access: yes, 2019
Dream experience (DE) represents a fascinating condition linked to emotional processes and the human inner world. Although the overlap between REM sleep and dreaming has been overcome, several studies point out that emotional and perceptually vivid ...
Bartolacci, Chiara   +4 more
core   +2 more sources

Narcolepsy Associated With Streptococcal Infection: A Case Report and Literature Review

open access: yesClinical Case Reports, Volume 13, Issue 12, December 2025.
ABSTRACT Streptococcal infection–induced narcolepsy is a rare neurological disorder that may be accompanied by severe psychiatric symptoms and social dysfunction. In this case, delayed diagnosis and treatment were followed by progressive symptom worsening, including marked cognitive decline.
Zhenzhen Zhu   +5 more
wiley   +1 more source

Narcolepsy, cataplexy, hypocretin and co-existing other health complaints: A review

open access: yesCogent Medicine, 2017
The presence of cataplexy in people with narcolepsy has a well-documented tight association with very low or non-detectable levels of the central nervous system neuropeptide, hypocretin (also termed orexin) while levels of hypocretin are normal in people
Samantha Gauci   +2 more
doaj   +1 more source

Prolonged Detection of GHB Intake in Urine: Are We Finally There?

open access: yesDrug Testing and Analysis, Volume 17, Issue 12, Page 2429-2446, December 2025.
In a randomised placebo‐controlled trial with 30 volunteers, urinary LC‐MS/MS analysis demonstrated that a tentative GHB‐pentose conjugate remained elevated in urine up to 72 h post‐administration. This biomarker showed clear distinction from placebo and may offer extended detection compared to GHB itself, representing a significant step forward in ...
Kathrine B. Faldborg   +4 more
wiley   +1 more source

Abnormal activity in hypothalamus and amygdala during humour processing in human narcolepsy with cataplexy [PDF]

open access: yes, 2017
Narcolepsy with cataplexy (NC) is a complex sleep-wake disorder, which was recently found to be associated with a reduction or loss of hypocretin (HCRT, also called orexin). HCRT is a hypothalamic peptide implicated in the regulation of sleep/wake, motor
Bassetti, C L.   +6 more
core  

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