Results 131 to 140 of about 9,368,793 (360)
Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova+18 more
wiley +1 more source
Entropy, Information and Complexity or Which Aims the Arrow of Time?
In this article, we analyze the interrelationships among such notions as entropy, information, complexity, order and chaos and show using the theory of categories how to generalize the second law of thermodynamics as a law of increasing generalized ...
George E. Mikhailovsky+1 more
doaj +1 more source
Direct products in the light of category theory [Lecture] [PDF]
Vladimír Kořínek
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Samuel Alexander’s Theory of Categories [PDF]
The Australian-born British philosopher Samuel Alexander (1859-1938) was one of the first realists of the twentieth century to defend a theory of categories. In Space, Time and Deity (1920) he constructs a realist metaphysics that posits Space-Time as the one monistic entity that encompasses every entity and every feature in reality, including the ...
openaire +4 more sources
Landscape of BRAF transcript variants in human cancer
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda+5 more
wiley +1 more source
Peter Freyd, Abeliwi Categories. An Introduction to the Theory of Functors (Harper and Row, 1964), xi+164 pp., $7.00. [PDF]
John Howie
openalex +1 more source
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed+8 more
wiley +1 more source
Some applications of module theory to functor categories [PDF]
Barry Mitchell
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Set theory for category theory
Questions of set-theoretic size play an essential role in category theory, especially the distinction between sets and proper classes (or small sets and large sets). There are many different ways to formalize this, and which choice is made can have noticeable effects on what categorical constructions are permissible.
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This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau+9 more
wiley +1 more source