Results 131 to 140 of about 9,831,323 (353)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Post-Neo-Kantianism and the Problem of Revival of Systematic Transcendental Philosophy

RUDN Journal of Philosophy
With a view to the question of a possible revival of systematic transcendental philosophy, the article follows the problem developments from outgoing neo-Kantianism to post-neo-Kantianism to the present day.
Kurt W. Zeidler, Vladimir N. Belov, Alexandra S. Perepechina   +2 more
doaj   +1 more source

Analysis and synthesis of a growing network model generating dense scale-free networks via category theory. [PDF]

Sci Rep, 2020
Haruna T, Gunji YP.
europepmc   +1 more source

Towards a Hermeneutic Categorical Mathematics or why Category theory goes beyond Mathematical Structuralism [PDF]

, 2006
Andrei Rodin
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Categories of Thought and Critical Theory: Anthropology and the Social Science of Medicine [PDF]

, 1986
Ellen S. Lazarus, Gregory Fernando Pappas   +1 more
openalex   +1 more source

Hermitian K-theory for stable $\\infty$-categories III: Grothendieck-Witt\n groups of rings [PDF]

, 2020
Baptiste Calmès, E. Dotto, Yonatan Harpaz, Fabian Hebestreit, Markus Land, Kristian Moi, Denis Nardin, Thomas Nikolaus, Wolfgang Steimle   +8 more
openalex   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Modular Theory, Non-Commutative Geometry and Quantum Gravity

Symmetry, Integrability and Geometry: Methods and Applications, 2010
This paper contains the first written exposition of some ideas (announced in a previous survey) on an approach to quantum gravity based on Tomita-Takesaki modular theory and A.
Wicharn Lewkeeratiyutkul, Paolo Bertozzini, Roberto Conti   +2 more
doaj   +1 more source