Results 1 to 10 of about 205,037 (299)

Arvcf Dependent Adherens Junction Stability is Required to Prevent Age-Related Cortical Cataracts

Frontiers in Cell and Developmental Biology, 2022
The etiology of age-related cortical cataracts is not well understood but is speculated to be related to alterations in cell adhesion and/or the changing mechanical stresses occurring in the lens with time.
Jessica B. Martin, Kenneth Herman, Nathalie S. Houssin, Wade Rich, Matthew A. Reilly, Matthew A. Reilly, Timothy F. Plageman   +6 more
doaj   +1 more source

p120-catenin subfamily members have distinct as well as shared effects on dendrite morphology during neuron development in vitro

Frontiers in Cellular Neuroscience, 2023
Dendritic arborization is essential for proper neuronal connectivity and function. Conversely, abnormal dendrite morphology is associated with several neurological pathologies like Alzheimer’s disease and schizophrenia.
Maxsam S. Donta, Maxsam S. Donta, Yogesh Srivastava, Christina M. Di Mauro, Adriana Paulucci-Holthauzen, M. Neal Waxham, M. Neal Waxham, Pierre D. McCrea, Pierre D. McCrea, Pierre D. McCrea   +9 more
doaj   +1 more source

Delta-Catenin as a Modulator of Rho GTPases in Neurons

Frontiers in Cellular Neuroscience, 2022
Small Rho GTPases are molecular switches that are involved in multiple processes including regulation of the actin cytoskeleton. These GTPases are activated (turned on) and inactivated (turned off) through various upstream effector molecules to carry out
Maxsam S. Donta, Maxsam S. Donta, Yogesh Srivastava, Pierre D. McCrea, Pierre D. McCrea, Pierre D. McCrea   +5 more
doaj   +1 more source

Exchange of catenins in cadherin–catenin complex [PDF]

Oncogene, 2003
beta-Catenin is an intracellular multifunctional protein. In complex with the transmembrane adhesive receptor E-cadherin, it becomes plasma membrane-associated and mediates intercellular adhesion. A cytosolic pool of beta-catenin interacts with DNA-binding proteins and participates in signal transduction. To reveal the possible cross-talk between these
Jörg Klingelhöfer, Regina B. Troyanovsky, Oscar Y. Laur, Oscar Y. Laur, Sergey M. Troyanovsky   +4 more
openaire   +4 more sources

Expression of β-Catenin and γ-Catenin in Maxillary Bone Regeneration [PDF]

International Journal of Immunopathology and Pharmacology, 2011
β- and γ-catenin are components of catenin family involved in cadherin adhesion function. Recently it has been shown that this family is involved in other functions such as signaling and activation of transcription factors. The final goal of this study was to evaluate the role of β- and γ-catenin in bone cell physiology and bone regeneration. Formalin-
Andrea Santarelli, Antonella Polimeni, Lorenzo Lo Muzio, Lorenzo Lo Muzio, Susanna Annibali, Francesco Carinci, Giuseppe Pannone, R. Rubini, Lucio Lo Russo, Giuseppe Colella, G Spinelli, N. Sgaramella   +11 more
openaire   +5 more sources

The catenin family at a glance [PDF]

Journal of Cell Science, 2010
Members of the catenin family were first isolated complexed with the cytoplasmic domains of cadherins at cell-cell junctions, and this relationship is considered one of the defining aspects of catenins. Their functions at such contacts are multifaceted and remain under active study and discussion.
Dongmin Gu, Dongmin Gu, Pierre D. McCrea
openaire   +2 more sources

Structure of the Dimerization and β-Catenin- Binding Region of α-Catenin [PDF]

Molecular Cell, 2000
In adherens junctions, alpha-catenin links the cadherin-beta-catenin complex to the actin-based cytoskeleton. alpha-catenin is a homodimer in solution, but forms a 1:1 heterodimer with beta-catenin. The crystal structure of the alpha-catenin dimerization domain, residues 82-279, shows that alpha-catenin dimerizes through formation of a four-helix ...
William I. Weis, Sabine Pokutta
openaire   +3 more sources

Identification of the Domain of α-Catenin Involved in Its Association with β-Catenin and Plakoglobin (γ-Catenin) [PDF]

Journal of Biological Chemistry, 1997
alpha-Catenin is a 102-kDa protein exhibiting homology to vincuin, and it forms complexes with cadherins or the tumor-suppressor gene product adenomatous polyposis coli through binding to beta-catenin or plakoglobin (gamma-catenin). The incorporation of alpha-catenin into the cadherin-catenin complexes is a prerequisite for expression of the cell ...
Hiroya Obama, Masayuki Ozawa
openaire   +3 more sources

Phosphorylation Reduces the Mechanical Stability of the α‐Catenin/ β‐Catenin Complex [PDF]

Angewandte Chemie International Edition, 2019
AbstractThe α‐catenin/β‐catenin complex serves as a critical molecular interface involved in cadherin–catenin‐based mechanosensing at the cell–cell adherence junction that plays a critical role in tissue integrity, repair, and embryonic development.
Shimin Le, Miao Yu, Jie Yan
openaire   +4 more sources

ECCU (E-cadherin/catenin) complex and its role in carcinogenesis

Journal of Education, Health and Sport, 2020
Introduction:One of the main characteristics of cancer is uncontrolled cell proliferation as well as loss of cells adhesion in the case of metastases. Cadherins and catenins are the molecules responsible for cell-to-cell interaction.
Alicja Maria Ozga, Aleksandra Obuchowska, Justyna Wójcik, Arkadiusz Standyło, Paulina Piotrowska   +4 more
doaj   +1 more source