Results 1 to 10 of about 220,813 (310)

15,16-Dihydrotanshinone I, a novel β-catenin-targeting inhibitor that inhibits its nuclear translocation and reduces downstream CD36 expression in cancer [PDF]

Journal of Translational Medicine
Background Wnt/β-catenin signaling drives many cancers; however, current inhibition strategies have limitations. Direct β-catenin inhibitors that block nuclear translocation represent an alternative therapeutic approach.
Minting Chen, Baisen Chen, Qianyi He, Shilin Xiao, Baoting Li, Yun Ye, Hongjie Zhang, Hoi Leong Xavier Wong, Ying Ji, Tao Su, Hiu Yee Kwan   +10 more
doaj   +2 more sources

Arvcf Dependent Adherens Junction Stability is Required to Prevent Age-Related Cortical Cataracts

Frontiers in Cell and Developmental Biology, 2022
The etiology of age-related cortical cataracts is not well understood but is speculated to be related to alterations in cell adhesion and/or the changing mechanical stresses occurring in the lens with time.
Jessica B. Martin, Kenneth Herman, Nathalie S. Houssin, Wade Rich, Matthew A. Reilly, Matthew A. Reilly, Timothy F. Plageman   +6 more
doaj   +1 more source

p120-catenin subfamily members have distinct as well as shared effects on dendrite morphology during neuron development in vitro

Frontiers in Cellular Neuroscience, 2023
Dendritic arborization is essential for proper neuronal connectivity and function. Conversely, abnormal dendrite morphology is associated with several neurological pathologies like Alzheimer’s disease and schizophrenia.
Maxsam S. Donta, Maxsam S. Donta, Yogesh Srivastava, Christina M. Di Mauro, Adriana Paulucci-Holthauzen, M. Neal Waxham, M. Neal Waxham, Pierre D. McCrea, Pierre D. McCrea, Pierre D. McCrea   +9 more
doaj   +1 more source

Delta-Catenin as a Modulator of Rho GTPases in Neurons

Frontiers in Cellular Neuroscience, 2022
Small Rho GTPases are molecular switches that are involved in multiple processes including regulation of the actin cytoskeleton. These GTPases are activated (turned on) and inactivated (turned off) through various upstream effector molecules to carry out
Maxsam S. Donta, Maxsam S. Donta, Yogesh Srivastava, Pierre D. McCrea, Pierre D. McCrea, Pierre D. McCrea   +5 more
doaj   +1 more source

Exchange of catenins in cadherin–catenin complex [PDF]

Oncogene, 2003
beta-Catenin is an intracellular multifunctional protein. In complex with the transmembrane adhesive receptor E-cadherin, it becomes plasma membrane-associated and mediates intercellular adhesion. A cytosolic pool of beta-catenin interacts with DNA-binding proteins and participates in signal transduction. To reveal the possible cross-talk between these
Klingelhöfer, Jörg, Troyanovsky, Regina B, Laur, Oscar Y, Troyanovsky, Sergey   +3 more
openaire   +3 more sources

p120 Catenin-Associated Fer and Fyn Tyrosine Kinases Regulate β-Catenin Tyr-142 Phosphorylation and β-Catenin-α-Catenin Interaction [PDF]

Molecular and Cellular Biology, 2003
beta-Catenin has a key role in the formation of adherens junction through its interactions with E-cadherin and alpha-catenin. We show here that interaction of beta-catenin with alpha-catenin is regulated by the phosphorylation of beta-catenin Tyr-142. This residue can be phosphorylated in vitro by Fer or Fyn tyrosine kinases.
Jose, Piedra, Susana, Miravet, Julio, Castaño, Héctor G, Pálmer, Nora, Heisterkamp, Antonio, García de Herreros, Mireia, Duñach   +6 more
openaire   +4 more sources

Ectopic γ-catenin expression partially mimics the effects of stabilized β-catenin on embryonic stem cell differentiation. [PDF]

PLoS ONE, 2013
β-catenin, an adherens junction component and key Wnt pathway effector, regulates numerous developmental processes and supports embryonic stem cell (ESC) pluripotency in specific contexts.
Sujeivan Mahendram, Kevin F Kelly, Sabrina Paez-Parent, Sharmeen Mahmood, Enio Polena, Austin J Cooney, Bradley W Doble   +6 more
doaj   +1 more source

ECCU (E-cadherin/catenin) complex and its role in carcinogenesis

Journal of Education, Health and Sport, 2020
Introduction:One of the main characteristics of cancer is uncontrolled cell proliferation as well as loss of cells adhesion in the case of metastases. Cadherins and catenins are the molecules responsible for cell-to-cell interaction.
Alicja Maria Ozga, Aleksandra Obuchowska, Justyna Wójcik, Arkadiusz Standyło, Paulina Piotrowska   +4 more
doaj   +1 more source

β-Catenin [PDF]

Journal of the American Society of Nephrology, 2011
Congenital anomalies of the kidney and urinary tract are the single most common cause of renal failure in childhood. Advances in the care of children with renal failure has primarily focused on optimizing the supportive, although nonspecific, treatment of chronic kidney disease and in addressing ...
Jacqueline Ho, Carlton M. Bates
openaire   +1 more source

Receptor and secreted targets of Wnt-1/β-catenin signalling in mouse mammary epithelial cells

BMC Cancer, 2005
Background Deregulation of the Wnt/ β-catenin signal transduction pathway has been implicated in the pathogenesis of tumours in the mammary gland, colon and other tissues.
Enver Tariq, Kenny Paraic A, Ashworth Alan   +2 more
doaj   +1 more source