Results 11 to 20 of about 205,037 (299)
Ectopic γ-catenin expression partially mimics the effects of stabilized β-catenin on embryonic stem cell differentiation. [PDF]
PLoS ONE, 2013 β-catenin, an adherens junction component and key Wnt pathway effector, regulates numerous developmental processes and supports embryonic stem cell (ESC) pluripotency in specific contexts.
Sujeivan Mahendram +6 more
doaj +1 more source
Beyond β-catenin: prospects for a larger catenin network in the nucleus [PDF]
Nature Reviews Molecular Cell Biology, 2015 β-catenin is widely regarded as the primary transducer of canonical WNT signals to the nucleus. In most vertebrates, there are eight additional catenins that are structurally related to β-catenin, and three α-catenin genes encoding actin-binding proteins that are structurally related to vinculin.
Cara J. Gottardi, Pierre D. McCrea
openaire +3 more sources
Receptor and secreted targets of Wnt-1/β-catenin signalling in mouse mammary epithelial cells
BMC Cancer, 2005 Background Deregulation of the Wnt/ β-catenin signal transduction pathway has been implicated in the pathogenesis of tumours in the mammary gland, colon and other tissues.
Enver Tariq +2 more
doaj +1 more source
β-Catenin expression is associated with cell invasiveness in pancreatic cancer [PDF]
The Korean Journal of Internal Medicine, 2019 Background/Aims This study was tried to determine the role of β-catenin in invasion in pancreatic cancer. Methods We analyzed cancer invasiveness according to β-catenin expression in pancreatic cancer cell line.
Jin Niang Nan, Ok Ran Kim, Myung Ah Lee
doaj +1 more source
p120 Catenin-Associated Fer and Fyn Tyrosine Kinases Regulate β-Catenin Tyr-142 Phosphorylation and β-Catenin-α-Catenin Interaction [PDF]
Molecular and Cellular Biology, 2003 beta-Catenin has a key role in the formation of adherens junction through its interactions with E-cadherin and alpha-catenin. We show here that interaction of beta-catenin with alpha-catenin is regulated by the phosphorylation of beta-catenin Tyr-142. This residue can be phosphorylated in vitro by Fer or Fyn tyrosine kinases.
Susana Miravet +7 more
openaire +4 more sources
Journal of Oral and Maxillofacial Pathology, 2016 In continuation with the previous review on "β-catenin in health", in this review we discuss the role of β-catenin in the pathogenesis of common oral lesions in the oral and maxillofacial region- oral potentially malignant disorders, their progression to oral squamous cell carcinoma, salivary gland tumors and odontogenic tumours.
Ashwini Balkuntla Krishnamurthy +3 more
openaire +4 more sources
Acetylation of β-Catenin by p300 Regulates β-Catenin-Tcf4 Interaction [PDF]
Molecular and Cellular Biology, 2004 Lysine acetylation modulates the activities of nonhistone regulatory proteins and plays a critical role in the regulation of cellular gene transcription. In this study, we showed that the transcriptional coactivator p300 acetylated beta-catenin at lysine 345, located in arm repeat 6, in vitro and in vivo.
Lévy, Laurence +6 more
openaire +3 more sources
Phosphorylation of β-Catenin by AKT Promotes β-Catenin Transcriptional Activity [PDF]
Journal of Biological Chemistry, 2007 Increased transcriptional activity of beta-catenin resulting from Wnt/Wingless-dependent or -independent signaling has been detected in many types of human cancer, but the underlying mechanism of Wnt-independent regulation is poorly understood. We have demonstrated that AKT, which is activated downstream from epidermal growth factor receptor signaling,
Yanhua Zheng +10 more
openaire +3 more sources
Distinct Activities of the α-Catenin Family, α-Catulin and α-Catenin, on β-Catenin-Mediated Signaling [PDF]
Molecular and Cellular Biology, 2004 α-Catenin, an integral part of cadherin-catenin adhesion complexes, is a major binding partner of β-catenin, a key component of the Wnt pathway, which activates T-cell factor (TCF)/lymphoid enhancer factor (LEF) transcription and is often upregulated in cancers.
Keith D. Merdek +2 more
openaire +2 more sources
Large Ovarian Microcystic Stromal Tumour: A Report of Rare and Distinctive Pathological Entity [PDF]
Journal of Clinical and Diagnostic ResearchMicrocystic Stromal Tumours (MCSTs) of the ovary are an exceedingly rare and distinct subtype of ovarian stromal neoplasms, characterised by their unique histopathological features. They were first identified in 2019 as a distinct entity.
Rhea Sharon Susihar +2 more
doaj +1 more source