Results 11 to 20 of about 416,309 (377)
Increasing β-catenin/Wnt3A activity levels drive mechanical strain-induced cell cycle progression through mitosis [PDF]
eLife, 2016 Mechanical force and Wnt signaling activate β-catenin-mediated transcription to promote proliferation and tissue expansion. However, it is unknown whether mechanical force and Wnt signaling act independently or synergize to activate β-catenin signaling ...
Blair W Benham-Pyle +4 more
doaj +4 more sources
Genome Biology, 2019 Background Circular RNAs are a class of regulatory RNA transcripts, which are ubiquitously expressed in eukaryotes. In the current study, we evaluate the function of a novel circRNA derived from the β-catenin gene locus, circβ-catenin.
Wei-Cheng Liang +10 more
doaj +2 more sources
Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities
Signal Transduction and Targeted Therapy, 2022 The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin signalling often leads to various serious diseases, including cancer and non-cancer
Jiaqi Liu +8 more
semanticscholar +1 more source
Arvcf Dependent Adherens Junction Stability is Required to Prevent Age-Related Cortical Cataracts
Frontiers in Cell and Developmental Biology, 2022 The etiology of age-related cortical cataracts is not well understood but is speculated to be related to alterations in cell adhesion and/or the changing mechanical stresses occurring in the lens with time.
Jessica B. Martin +6 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2023 Dendritic arborization is essential for proper neuronal connectivity and function. Conversely, abnormal dendrite morphology is associated with several neurological pathologies like Alzheimer’s disease and schizophrenia.
Maxsam S. Donta +9 more
doaj +1 more source
Delta-Catenin as a Modulator of Rho GTPases in Neurons
Frontiers in Cellular Neuroscience, 2022 Small Rho GTPases are molecular switches that are involved in multiple processes including regulation of the actin cytoskeleton. These GTPases are activated (turned on) and inactivated (turned off) through various upstream effector molecules to carry out
Maxsam S. Donta +5 more
doaj +1 more source
Exchange of catenins in cadherin–catenin complex [PDF]
Oncogene, 2003 beta-Catenin is an intracellular multifunctional protein. In complex with the transmembrane adhesive receptor E-cadherin, it becomes plasma membrane-associated and mediates intercellular adhesion. A cytosolic pool of beta-catenin interacts with DNA-binding proteins and participates in signal transduction. To reveal the possible cross-talk between these
Jörg Klingelhöfer +4 more
openaire +4 more sources
Wnt/beta-catenin signaling confers ferroptosis resistance by targeting GPX4 in gastric cancer
Cell Death and Differentiation, 2022 The development of chemotherapy resistance is the most vital obstacle to clinical efficacy in gastric cancer (GC). The dysregulation of the Wnt/beta-catenin signaling pathway is critically associated with GC development and chemotherapy resistance ...
Yue Wang +14 more
semanticscholar +1 more source
Expression of β-Catenin and γ-Catenin in Maxillary Bone Regeneration [PDF]
International Journal of Immunopathology and Pharmacology, 2011 β- and γ-catenin are components of catenin family involved in cadherin adhesion function. Recently it has been shown that this family is involved in other functions such as signaling and activation of transcription factors. The final goal of this study was to evaluate the role of β- and γ-catenin in bone cell physiology and bone regeneration. Formalin-
Andrea Santarelli +11 more
openaire +5 more sources
Wnt/β-catenin signaling in cancers and targeted therapies
Signal Transduction and Targeted Therapy, 2021 Wnt/β-catenin signaling has been broadly implicated in human cancers and experimental cancer models of animals. Aberrant activation of Wnt/β-catenin signaling is tightly linked with the increment of prevalence, advancement of malignant progression ...
F. Yu +8 more
semanticscholar +1 more source