Results 11 to 20 of about 220,813 (310)
Discovery of novel small molecule activators of β-catenin signaling. [PDF]
PLoS ONE, 2011 Wnt/β-catenin signaling plays a major role in embryonic development and adult stem cell maintenance. Reduced activation of the Wnt/β-catenin pathway underlies neurodegenerative disorders and aberrations in bone formation.
Folkert Verkaar +4 more
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Large Ovarian Microcystic Stromal Tumour: A Report of Rare and Distinctive Pathological Entity [PDF]
Journal of Clinical and Diagnostic ResearchMicrocystic Stromal Tumours (MCSTs) of the ovary are an exceedingly rare and distinct subtype of ovarian stromal neoplasms, characterised by their unique histopathological features. They were first identified in 2019 as a distinct entity.
Rhea Sharon Susihar +2 more
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β-Catenin expression is associated with cell invasiveness in pancreatic cancer [PDF]
The Korean Journal of Internal Medicine, 2019 Background/Aims This study was tried to determine the role of β-catenin in invasion in pancreatic cancer. Methods We analyzed cancer invasiveness according to β-catenin expression in pancreatic cancer cell line.
Jin Niang Nan, Ok Ran Kim, Myung Ah Lee
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Frontiers in Oncology, 2022 Casein kinase 1δ/ϵ (CK1δ/ϵ) are well-established positive modulators of the Wnt/β-catenin signaling pathway. However, the molecular mechanisms involved in the regulation of β-catenin transcriptional activity by CK1δ/ϵ remain unclear.
Jiong Ning +13 more
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Z-Ajoene Inhibits Growth of Colon Cancer by Promotion of CK1α Dependent β-Catenin Phosphorylation
Molecules, 2020 Aberrant activation of a Wnt/β-catenin pathway results in nuclear accumulation of β-catenin in colon cancer. Inhibiting β-catenin is one strategy for treating colon cancer.
Hua Li +5 more
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Journal of the American Society of Nephrology, 2012 Wnt/ β -catenin signaling plays a significant role during kidney development and maturation.[1][1][][2]–[3][3] β -Catenin, the canonical Wnt signal transducer, is involved in nephron induction[4][4],[5][5] and branching morphogenesis.[1][1],[6][6] Importantly, β -catenin modulation is ...
openaire +2 more sources
Increased Expression of Adherens Junction Components in Mouse Liver following Bile Duct Ligation
Biomolecules, 2019 Adherens junctions, consisting of cadherins and catenins, are a group of cell-to-cell junctions that mediate mechanistic linkage between neighboring cells. By doing so, adherens junctions ensure direct intercellular contact and play an indispensable role
Raf Van Campenhout +9 more
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Neoplasia: An International Journal for Oncology Research, 2013 β-Catenin is important in liver homeostasis as a part of Wnt signaling and adherens junctions (AJs), while its aberrant activation is observed in hepatocellular carcinoma (HCC).
Emily Diane Wickline +4 more
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Exiting the dark side: A vital role for Caspase-3 in Yap signaling
Molecular & Cellular Oncology, 2018 Caspase-3 is known to play a critical function in the process of apoptosis. Recently, we have discovered a non-apoptotic role of Caspase-3 as a key regulator of cell proliferation and organ size.
Yahav Yosefzon, Yaron Fuchs
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LEF-1 drives aberrant β-catenin nuclear localization in myeloid leukemia cells
Haematologica, 2019 Canonical Wnt/β-catenin signaling is frequently dysregulated in myeloid leukemias and is implicated in leukemogenesis. Nuclear-localized β-catenin is indicative of active Wnt signaling and is frequently observed in acute myeloid leukemia (AML) patients ...
Rhys G. Morgan +12 more
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