Results 21 to 30 of about 205,037 (299)
Discovery of novel small molecule activators of β-catenin signaling. [PDF]
PLoS ONE, 2011 Wnt/β-catenin signaling plays a major role in embryonic development and adult stem cell maintenance. Reduced activation of the Wnt/β-catenin pathway underlies neurodegenerative disorders and aberrations in bone formation.
Folkert Verkaar +4 more
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Journal of the American Society of Nephrology, 2012 Wnt/ β -catenin signaling plays a significant role during kidney development and maturation.[1][1][][2]–[3][3] β -Catenin, the canonical Wnt signal transducer, is involved in nephron induction[4][4],[5][5] and branching morphogenesis.[1][1],[6][6] Importantly, β -catenin modulation is ...
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Increased Expression of Adherens Junction Components in Mouse Liver following Bile Duct Ligation
Biomolecules, 2019 Adherens junctions, consisting of cadherins and catenins, are a group of cell-to-cell junctions that mediate mechanistic linkage between neighboring cells. By doing so, adherens junctions ensure direct intercellular contact and play an indispensable role
Raf Van Campenhout +9 more
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Z-Ajoene Inhibits Growth of Colon Cancer by Promotion of CK1α Dependent β-Catenin Phosphorylation
Molecules, 2020 Aberrant activation of a Wnt/β-catenin pathway results in nuclear accumulation of β-catenin in colon cancer. Inhibiting β-catenin is one strategy for treating colon cancer.
Hua Li +5 more
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Frontiers in Oncology, 2022 Casein kinase 1δ/ϵ (CK1δ/ϵ) are well-established positive modulators of the Wnt/β-catenin signaling pathway. However, the molecular mechanisms involved in the regulation of β-catenin transcriptional activity by CK1δ/ϵ remain unclear.
Jiong Ning +13 more
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Neoplasia: An International Journal for Oncology Research, 2013 β-Catenin is important in liver homeostasis as a part of Wnt signaling and adherens junctions (AJs), while its aberrant activation is observed in hepatocellular carcinoma (HCC).
Emily Diane Wickline +4 more
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The -Catenin Destruction Complex [PDF]
Cold Spring Harbor Perspectives in Biology, 2012 The Wnt/β-catenin pathway is highly regulated to insure the correct temporal and spatial activation of its target genes. In the absence of a Wnt stimulus, the transcriptional coactivator β-catenin is degraded by a multiprotein "destruction complex" that includes the tumor suppressors Axin and adenomatous polyposis coli (APC), the Ser/Thr kinases GSK-3 ...
William I. Weis, Jennifer L. Stamos
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S-Nitrosation of β-Catenin and p120 Catenin [PDF]
Circulation Research, 2012 Rationale: Endothelial adherens junction proteins constitute an important element in the control of microvascular permeability. Platelet-activating factor (PAF) increases permeability to macromolecules via translocation of endothelial nitric oxide synthase (eNOS) to cytosol and stimulation of eNOS ...
Rodrigo Carrasco +10 more
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LEF-1 drives aberrant β-catenin nuclear localization in myeloid leukemia cells
Haematologica, 2019 Canonical Wnt/β-catenin signaling is frequently dysregulated in myeloid leukemias and is implicated in leukemogenesis. Nuclear-localized β-catenin is indicative of active Wnt signaling and is frequently observed in acute myeloid leukemia (AML) patients ...
Rhys G. Morgan +12 more
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Exiting the dark side: A vital role for Caspase-3 in Yap signaling
Molecular & Cellular Oncology, 2018 Caspase-3 is known to play a critical function in the process of apoptosis. Recently, we have discovered a non-apoptotic role of Caspase-3 as a key regulator of cell proliferation and organ size.
Yahav Yosefzon, Yaron Fuchs
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